Variolin B and its derivate deoxy-variolin B: New marine natural compounds with cyclin-dependent kinase inhibitor activity

European Journal of Cancer

Volumn 41, Issue 15, 2005, Pages 2366-2377

  Simone, Matteo ^a   Erba, Eugenio ^a   Damia, Giovanna ^a   Vikhanskaya, Faina ^a   Di Francesco, Angela M ^b   Riccardi, Riccardo ^b   Bailly, Christian ^c   Cuevas, Carmen ^d   Fernandez Sousa Faro, José Maria ^d   D'Incalci, Maurizio ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^c CENTRE OSCAR LAMBRET   (France)

^d PHARMAMAR S A   (Spain)

Author keywords

Apoptosis; CDK inhibitors; CDKs; Marine natural compounds; p53

Indexed keywords

CYCLIN A; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; CYCLIN H; CYCLINE; DEOXYVARIOLIN B; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); NATURAL PRODUCT; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG; VARIOLIN B;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; COLONY FORMATION; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE INACTIVATION; GENE INDUCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; WILD TYPE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZA COMPOUNDS; CASPASE 3; CASPASES; CELL DIVISION; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASES; DNA, NEOPLASM; HUMANS; PYRIMIDINES;

EID: 26244464019     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.05.015     Document Type: Article

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