Molecular basis of functional gastrointestinal disorders

Best Practice and Research: Clinical Gastroenterology

Volumn 18, Issue 4, 2004, Pages 633-640

  Holtmann, Gerald ^a   Liebregts, Tobias ^a   Siffert, Winfried ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Functional dyspepsia; Functional gastrointestinal disorders; G protein; Irritable bowel disorders; Irritable bowel syndrome; Psychiatric comorbidity; Serotonin transporter

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; OPIATE RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL FEATURE; COMORBIDITY; DIGESTIVE SYSTEM FUNCTION DISORDER; DIZYGOTIC TWINS; DNA POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC RISK; HUMAN; IMMUNOMODULATION; MEDIATOR; MENTAL DISEASE; MONOZYGOTIC TWINS; MOTOR DYSFUNCTION; MUCOSA INFLAMMATION; NONHUMAN; PATHOPHYSIOLOGY; SENSORY DYSFUNCTION; SEROTONINERGIC SYSTEM; SYMPTOMATOLOGY;

ANIMALS; COMORBIDITY; DISEASE MODELS, ANIMAL; GASTROINTESTINAL DISEASES; GTP-BINDING PROTEINS; HUMANS; MENTAL DISORDERS; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, BETA-3;

EID: 4344588972     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpg.2004.04.006     Document Type: Article

References (53)

1. Drossman D.A. Camilleri M. Mayer E.A. Whitehead W.E. AGA technical review on irritable bowel syndrome Gastroenterology 123 2002 2108-2131
2. Talley N.J. Silverstein M.D. Agreus L. et al. AGA technical review: Evaluation of dyspepsia Gastroenterology 114 1998 582-595
3. Thompson W.G. Longstreth G.F. Drossman D.A. et al. Functional bowel disorders and functional abdominal pain Gut 45 suppl 2 1999 II43-II47
4. Drossman D.A. Diagnosing and treating patients with refractory functional gastrointestinal disorders Annals of Internal Medicine 123 1995 688-697
5. Drossman D.A. Thompson W.G. Talley N.J. et al. Identification of sub-groups of functional gastrointestinal disorders Gastroenterology International 3 1990 159-172
6. Drossman D.A. Richter J.E. Talley N.J. et al. The Functional Gastrointestinal Disorders 1994 Little, Brown and Company Boston
7. Luscombe F.A. Health-related quality of life and associated psychosocial factors in irritable bowel syndrome: A review Quality of Life Research 9 2000 161-176
8. Talley N.J. Weaver A.L. Zinsmeister A.R. Impact of functional dyspepsia on quality of life Digestive Diseases and Sciences 40 1995 584-589
9. Talley N.J. Gabriel S.E. Harmsen W.S. et al. Medical costs in community subjects with irritable bowel syndrome Gastroenterology 109 1995 1736-1741
10. Nyrén O. Lindberg G. Lindström E. et al. Economic costs of functional dyspepsia Pharmacoeconomics 1 1992 312-324
11. Azpiroz F. Functional dyspepsia: Recent pathophysiological advances Acta Gastroenterologica Belgica 53 1990 518-522
12. Drossman D.A. Psychosocial factors in functional dyspepsia European Journal of Gastroenterology and Hepatology 4 1992 602-607
13. Alpers D.H. Functional gastrointestinal disorders Hospital Practice 18 1983 139-153
14. Bennett E. Beaurepaire J. Langeluddecke P. et al. Life stress and non-ulcer dyspepsia: A case-control study Journal of Psychosomatic Research 35 1991 579-590
15. Bennett E.J. Tennant C.C. Piesse C. et al. Level of chronic life stress predicts clinical outcome in irritable bowel syndrome Gut 43 1998 256-261
16. Neal K.R. Hebden J. Spiller R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of irritable bowel syndrome: Postal survey of patients British Medical Journal 314 1997 779-782
17. Stanghellini V. Tosetti C. Paternico A. et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia Gastroenterology 110 1996 1036-1042
18. Tack J. Piessevaux H. Coulie B. et al. Role of impaired gastric accommodation to a meal in functional dyspepsia Gastroenterology 115 1998 1346-1352
19. Holtmann G. Goebell H. Jockenhövel F. Talley N.J. Altered vagal and intestinal mechano-sensory function in chronic unexplained dyspepsia Gut 42 1998 501-506
20. Coffin B. Azpiroz F. Malagelada J.R. Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia Gastroenterology 100 1991 A431
21. Drossman D.A. McKee D.C. Sandler R.S. et al. Psychological factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome Gastroenterology 95 1988 701-708
22. Drossman D.A. Personality and psychosocial factors in the irritable bowel syndrome Gastroenterologie Clinique et Biologique 14 1990 49C-53C
23. Addolorato G. Marsigli L. Capristo E. et al. Anxiety and depression: A common feature of health care seeking patients with irritable bowel syndrome and food allergy Hepatogastroenterology 45 1998 1559-1564
24. Holtmann G. Talley N.J. Mitchell H. Hazell S. Antibody response to specific H. pylori antigens in functional dyspepsia, duodenal ulcer disease, and health American Journal of Gastoenterology 93 1998 1222-1227
25. McKendrick M.W. Read N.W. Irritable bowel syndrome-post salmonella infection The Journal of Infection 29 1994 1-3
26. Tack J. Demedts I. Dehondt G. et al. Clinical and pathophysiologic characteristics of acute-onset functional dyspepsia Gastroenterology 122 2002 1738-1747
27. Locke G.R. III Zinsmeister A.R. Talley N.J. et al. Familial association in adults with functional gastrointestinal disorders Mayo Clinic Proceedings 75 2000 907-912
28. Levy R.L. Jones K.R. Whitehead W.E. et al. Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology Gastroenterology 121 2001 799-804
29. Morris-Yates A. Talley N.J. Boyce P.M. et al. Evidence of a genetic contribution to functional bowel disorder American Journal of Gastroenterology 93 1998 1311-1317
30. Lenbo T. Zaman M.S. Chavez N.F. et al. Concordance of IBS among monozygotic and dizygotic twins Gastroenterology 120 suppl 1 2001 A-66
31. Holtmann G. Dietrich E. Reuss E. et al. H. pylori and the development of functional gastrointestinal disorders: A twin study Gastroenterology 124 2003 A391
32. Coutinho S.V. Miller J.C. Hubel K. et al. Differential involvement of spinal NMDA, CGRP and NK1 receptors in responses to phasic vs. tonic colorectal distension Gastroenterology 118 2000 2009
33. Gschossmann J.M. Holtmann G. Liebregts T. et al. An animal model of postinflammatory visceral hyperalgesia in response to colorectal distension: Discrepancy of long-term sensory alterations and tissue damage Gastroenterology 116 1999 G4346
34. Buenger L. Gschossmann J. Gerken G. Holtmann G. Diurnal variation of abdominal motor responses to colorectal distension in a rat model Gastroenterology 118 2000 814
35. Gschossmann J.M. Adam B. Liebregts T. et al. Influence of the sexual hormones an the post-inflammatory sensory function in female rats Gastroenterology 122 2002 A526
36. Burton M.B. Gebhart G.F. Effects of kappa-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammation The Journal of Pharmacology and Experimental Therapeutics 285 1998 707-715
37. Coutinho S.V. Gebhart G.F. A role for spinal nitric oxide in mediating visceral hyperalgesia in the rat Gastroenterology 116 1999 1399-1408
38. Danzebrink R.M. Green S.A. Gebhart G.F. Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat Pain 63 1995 39-47
39. Gschossmann J. Holtmann G. Adam B. et al. Strain differences in the visceromotor response to colorectal distension during trinitrobenzenesulfonic acid-induced colitis Gastroenterology 116 1999 A607
40. Kellow J.E. Miller L.J. Phillips S.F. et al. Altered sensitivity of the gallbladder to cholecystokinin octapeptide in irritable bowel syndrome American Journal of Physiology: Gastrointestinal Liver Physiology 253 1987 G650-G655
41. Chua A. Keating J. Hamilton D. et al. Central serotonin receptors and delayed gastric emptying in non-ulcer dyspepsia British Medical Journal 305 1992 280-282
42. Dinan T.G. Barry S. Ahkion S. et al. Assessment of central noradrenergic functioning in irritable bowel syndrome using a neuroendocrine challenge test Journal of Psychosomatic Research 34 1990 575-580
43. Bharucha A.E. Camilleri M. Zinsmeister A.R. Hanson R.B. Adrenergic modulation of human colonic motor and sensory function American Journal of Physiology 273 1997 G997-1006
44. Gershon M.D. Wade P.R. Kirchgessner A.L. Tamir H. 5-HT receptor subtypes outside the central nervous system: Roles in the physiology of the gut Neuropsychopharmacology 3 1990 385-395
45. Gollasch M. Kleuss C. Hescheler J. et al. Gi2 and protein kinase C are required for thyrotropin-releasing hormone-induced stimulation of voltage-dependent Ca2+ channels in rat pituitary GH3 cells Proceedings of the National Academy of Sciences USA 90 1993 6265-6269
46. Kleuss C. Hescheler J. Ewel C. et al. Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents Nature 353 1991 43-48
47. Kleuss C. Scherubl H. Hescheler J. et al. Different beta-subunits determine G-protein interaction with transmembrane receptors Nature 358 1992 424-426
48. Kleuss C. Scherubl H. Hescheler J. et al. Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins Science 259 1993 832-834
49. Baumgart D. Naber C. Haude M. et al. G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation Circulation Research 85 1999 965-969
50. Zill P. Baghai T.C. Zwanzger P. et al. Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment Neuroreport 11 2000 1893-1897
51. Lindemann M. Virchow S. Ramann F. et al. The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response FEBS Letters 495 2001 82-86
52. Holtmann G. Gschossmann J. Neufang-Huber J. et al. Differences in gastric mechanosensory function after repeated ramp distensions in non-consulters with dyspepsia and healthy controls Gut 47 2000 332-336
53. Gschossmann J. Liebregts T. Adam B. Holtmann G. Long term effects of an acute chemically induced colitis on the visceromotor response to mechanical colorectal distension Digestive Diseases and Sciences 2004 in press