Diminished cytokine and chemokine expression in the central nervous system of GMF-deficient mice with experimental autoimmune encephalomyelitis

Brain Research

Volumn 1144, Issue 1, 2007, Pages 239-247

  Zaheer, Asgar ^a,b   Sahu, Shailendra K ^b   Wu, Yanghong ^b   Zaheer, Ashna ^c   Haas, Joel ^a   Lee, Kiwhoon ^b   Yang, Baoli ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Cytokine Chemokine; Experimental autoimmune encephalomyelitis (EAE); Glia maturation factor (GMF); Inflammation; Multiple sclerosis (MS); Myelin oligodendrocyte glycoprotein (MOG)

Indexed keywords

CHEMOKINE; CYTOKINE; ENCEPHALITOGENIC PROTEIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLIA MATURATION FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; FEMALE; IMMUNIZATION; KNOCKOUT MOUSE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; SPINAL CORD;

ANALYSIS OF VARIANCE; ANIMALS; CENTRAL NERVOUS SYSTEM; CHEMOKINES; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GLIA MATURATION FACTOR; GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA; MUS;

EID: 33947320316     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.01.075     Document Type: Article

References (41)

1. Beckman J.S., and Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol. 271 (1996) C1424-C1437
2. Brosnan C.F., et al. Reactive nitrogen intermediates in human neuropathology: an overview. Dev. Neurosci. 16 (1994) 152-161
3. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
4. Cross A.H., et al. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest. 93 (1994) 2684-2690
5. Dasgupta S., et al. Myelin basic protein-primed T cells induce nitric oxide synthase in microglial cells. Implications for multiple sclerosis. J. Biol. Chem. 277 (2002) 39327-39333
6. Ding M., et al. Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice. J. Immunol. 160 (1998) 2560-2564
7. Genain C.P., and Hauser S.L. Experimental allergic encephalomyelitis in the New World monkey Callithrix jacchus. Immunol. Rev. 183 (2001) 159-172
8. Godiska R., et al. Chemokine expression in murine experimental allergic encephalomyelitis. J. Neuroimmunol. 58 (1995) 167-176
9. Hamilton N.H., et al. IFN-gamma regulates murine interferon-inducible T cell alpha chemokine (I-TAC) expression in dendritic cell lines and during experimental autoimmune encephalomyelitis (EAE). Scand. J. Immunol. 55 (2002) 171-177
10. Hilliard B., et al. Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice: roles of NF-kappa B in the activation and differentiation of autoreactive T cells. J. Immunol. 163 (1999) 2937-2943
11. Howard L.M., and Miller S.D. Autoimmune intervention by CD154 blockade prevents T cell retention and effector function in the target organ. J. Immunol. 166 (2001) 1547-1553
12. Iglesias A., et al. T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 36 (2001) 220-234
13. Kaplan R., et al. Molecular cloning and expression of biologically active human glia maturation factor-beta. J. Neurochem. 57 (1991) 483-490
14. Lim R., and Zaheer A. In vitro enhancement of p38 mitogen-activated protein kinase activity by phosphorylated glia maturation factor. J. Biol. Chem. 271 (1996) 22953-22956
15. Lim R., et al. Purification and characterization of glia maturation factor beta: a growth regulator for neurons and glia. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 3901-3905
16. Lim R., et al. Complete amino acid sequence of bovine glia maturation factor beta. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 5233-5237
17. Lim R., et al. Activation of nuclear factor-kappaB in C6 rat glioma cells after transfection with glia maturation factor. J. Neurochem. 74 (2000) 596-602
18. Lim R., et al. Impaired motor performance and learning in glia maturation factor-knockout mice. Brain Res. 1024 (2004) 225-232
19. Linington C., et al. T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. Eur. J. Immunol. 23 (1993) 1364-1372
20. Liu J., et al. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat. Med. 4 (1998) 78-83
21. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(- Delta Delta C(T)) method. Methods 25 (2001) 402-408
22. Matejuk A., et al. Effects of cytokine deficiency on chemokine expression in CNS of mice with EAE. J. Neurosci. Res. 67 (2002) 680-688
23. Merrill J.E., et al. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151 (1993) 2132-2141
24. Mitrovic B., et al. Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro. Neuroscience 61 (1994) 575-585
25. Noseworthy J.H., et al. Multiple sclerosis. N. Engl. J. Med. 343 (2000) 938-952
26. Ransohoff R.M., et al. Chemokines in immune-mediated inflammation of the central nervous system. Cytokine Growth Factor Rev. 7 (1996) 35-46
27. Samoilova E.B., et al. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol. 161 (1998) 6480-6486
28. Sherman M.P., et al. Nitric oxide-mediated neuronal injury in multiple sclerosis. Med. Hypotheses 39 (1992) 143-146
29. Smith K.J., et al. Demyelination: the role of reactive oxygen and nitrogen species. Brain Pathol. 9 (1999) 69-92
30. Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85 (1996) 299-302
31. Stoll G., et al. Cytokines in CNS disorders: neurotoxicity versus neuroprotection. J. Neural Transm., Suppl. 59 (2000) 81-89
32. Tuohy V.K. Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: a review. Neurochem. Res. 19 (1994) 935-944
33. Voskuhl R.R., et al. Epitope spreading occurs in active but not passive EAE induced by myelin basic protein. J. Neuroimmunol. 70 (1996) 103-111
34. Zaheer A., and Lim R. Overexpression of glia maturation factor (GMF) in PC12 pheochromocytoma cells activates p38 MAP kinase, MAPKAP kinase-2, and tyrosine hydroxylase. Biochem. Biophys. Res. Commun. 250 (1998) 278-282
35. Zaheer A., et al. Expression of mRNAs of multiple growth factors and receptors by neuronal cell lines: detection with RT-PCR. Neurochem. Res. 20 (1995) 1457-1463
36. Zaheer A., et al. Expression of mRNAs of multiple growth factors and receptors by astrocytes and glioma cells: detection with reverse transcription-polymerase chain reaction. Cell. Mol. Neurobiol. 15 (1995) 221-237
37. Zaheer A., et al. Effects of glia maturation factor overexpression in primary astrocytes on MAP kinase activation, transcription factor activation, and neurotrophin secretion. Neurochem. Res. 26 (2001) 1293-1299
38. Zaheer A., et al. Overexpression of glia maturation factor in astrocytes leads to immune activation of microglia through secretion of granulocyte-macrophage-colony stimulating factor. Biochem. Biophys. Res. Commun. 294 (2002) 238-244
39. Zaheer A., et al. Decreased copper-zinc superoxide dismutase activity and increased resistance to oxidative stress in glia maturation factor-null astrocytes. Neurochem. Res. 29 (2004) 1473-1480
40. Zaheer, A. et al., in press. A novel role of glia maturation factor: induction of granulocyte-macrophage-colony stimulating factor and pro inflammatory cytokines. J. Neurochem. doi:10.1111/j.1471-4159.2006.04385.x.
41. Zaheer A., et al. Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice. Neurochem. Res. 32 (2007) 39-47