The reduction of hemodynamic loading assists self-regeneration of the injured heart by increasing cell proliferation, inhibiting cell apoptosis, and inducing stem-cell recruitment

Journal of Thoracic and Cardiovascular Surgery

Volumn 133, Issue 4, 2007, Pages 1051-1058

  Suzuki, Ryo ^a   Li, Tao Sheng ^a   Mikamo, Akihito ^a   Takahashi, Masaya ^a   Ohshima, Mako ^a   Kubo, Masayuki ^a   Ito, Hiroshi ^a   Hamano, Kimikazu ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; KI 67 ANTIGEN; STEM CELL FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ARTERY LIGATION; HEART INFARCTION; HEART INJURY; HEART TRANSPLANTATION; HEMODYNAMICS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TISSUE REGENERATION;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; HEART; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; REGENERATION; STEM CELLS; VENTRICULAR PRESSURE;

EID: 33947288487     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2006.12.026     Document Type: Article

References (31)

1. Zak R. Development and proliferative capacity of cardiac muscle cells. Circ Res 35 suppl II (1974) 17-26
2. Kajstura J., Leri A., Finato N., Di Loreto C., Beltrami C.A., and Anversa P. Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci U S A 95 (1998) 8801-8805
3. Beltrami A.P., Urbanek K., Kajstura J., et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 344 (2001) 1750-1757
4. Oh H., Bradfute S.B., Gallardo T.D., et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A 100 (2003) 12313-12318
5. Beltrami A.P., Barlucchi L., Torella D., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114 (2003) 763-776
6. Laugwitz K.L., Moretti A., Lam J., et al. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 433 (2005) 647-653
7. Matsuura K., Nagai T., Nishigaki N., et al. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem 279 (2004) 11384-11391
8. Vanderheyden M., Paulus W.J., Voss M., et al. Myocardial cytokine gene expression is higher in aortic stenosis than in idiopathic dilated cardiomyopathy. Heart 91 (2005) 926-931
9. Olivetti G., Abbi R., Quaini F., et al. Apoptosis in the failing human heart. N Engl J Med 336 (1997) 1131-1141
10. Muller J., Wallukat G., Weng Y.G., et al. Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation 96 (1997) 542-549
11. Frazier O.H., and Myers T.J. Left ventricular assist system as a bridge to myocardial recovery. Ann Thorac Surg 68 (1999) 734-741
12. Simon M.A., Kormos R.L., Murali S., et al. Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes. Circulation 112 9 suppl (2005) I32-I36
13. Dang N.C., Topkara V.K., Leacche M., John R., Byrne J.G., and Naka Y. Left ventricular assist device implantation after acute anterior wall myocardial infarction and cardiogenic shock: a two-center study. J Thorac Cardiovasc Surg 130 (2005) 693-698
14. Li T.S., Hayashi M., Ito H., et al. Regeneration of infarcted myocardium by intramyocardial implantation of ex vivo transforming growth factor-beta-preprogrammed bone marrow stem cells. Circulation 111 (2005) 2438-2445
15. Hamano K., Rawsthorne M.A., Bushell A.R., Morris P.J., and Wood K.J. Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients. Transplantation 62 (1996) 856-860
16. Levin H.R., Oz M.C., Chen J.M., Packer M., Rose E.A., and Burkhoff D. Reversal of chronic ventricular dilation in patients with end-stage cardiomyopathy by prolonged mechanical unloading. Circulation 91 (1995) 2717-2720
17. McCarthy P.M., Nakatani S., Vargo R., et al. Structural and left ventricular histologic changes after implantable LVAD insertion. Ann Thorac Surg 59 (1995) 609-613
18. Barbone A., Holmes J.W., Heerdt P.M., et al. Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: a primary role of mechanical unloading underlying reverse remodeling. Circulation 104 (2001) 670-675
19. Dipla K., Mattiello J.A., Jeevanandam V., Houser S.R., and Margulies K.B. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. Circulation 97 (1998) 2316-2322
20. McGowan B.S., Scott C.B., Mu A., McCormick R.J., Thomas D.P., and Margulies K.B. Unloading-induced remodeling in the normal and hypertrophic left ventricle. Am J Physiol Heart Circ Physiol 284 (2003) H2061-H2068
21. Klotz S., Foronjy R.F., Dickstein M.L., et al. Mechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness. Circulation 112 (2005) 364-374
22. Blaxall B.C., Tschannen-Moran B.M., Milano C.A., and Koch W.J. Differential gene expression and genomic patient stratification following left ventricular assist device support. J Am Coll Cardiol 41 (2003) 1096-1106
23. Heerdt P.M., Holmes J.W., Cai B., et al. Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure. Circulation 102 (2000) 2713-2719
24. Bartling B., Milting H., Schumann H., et al. Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure. Circulation 100 19 suppl (1999) II216-II223
25. Hattori T. Effect of mechanical assist devices for ischemic myocardial damage-cardiomyocyte apoptosis and TNF-alpha. Ann Thorac Cardiovasc Surg 9 (2003) 233-240
26. Ito K., Nakayama M., Hasan F., Yan X., Schneider M.D., and Lorell B.H. Contractile reserve and calcium regulation are depressed in myocytes from chronically unloaded hearts. Circulation 107 (2003) 1176-1182
27. Tevaearai H.T., Walton G.B., Eckhart A.D., Keys J.R., and Koch W.J. Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts. J Thorac Cardiovasc Surg 124 (2002) 1149-1156
28. Wojakowski W., Tendera M., Michalowska A., et al. Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction. Circulation 110 (2004) 3213-3220
29. Wohlschlaeger J., Schmitz K.J., Schmid C., et al. Reverse remodeling following insertion of left ventricular assist devices (LVAD): a review of the morphological and molecular changes. Cardiovasc Res 68 (2005) 376-386
30. Sukehiro S., and Flameng W. Effects of left ventricular assist for cardiogenic shock on cardiac function and organ blood flow distribution. Ann Thorac Surg 50 (1990) 374-383
31. Ankersmit H.J., Edwards N.M., Schuster M., et al. Quantitative changes in T-cell populations after left ventricular assist device implantation: relationship to T-cell apoptosis and soluble CD95. Circulation 100 19 suppl (1999) II211-II215