Effect of chelation with meso-Dimercaptosuccinic acid (DMSA) before and after the appearance of lead-induced neurotoxicity in the rat

Toxicology and Applied Pharmacology

Volumn 144, Issue 2, 1997, Pages 205-214

  Gong, Zhaolong ^a,b   Evans, Hugh L ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; LEAD; LEAD ACETATE; SUCCIMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHELATION; CONTROLLED STUDY; HYPERACTIVITY; MALE; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; REARING;

EID: 0031172435     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8118     Document Type: Article

References (62)

1. Agency for Toxic Substances and Disease Registry (ATSDR). (1993). Toxicological Profile for Lead (Update). U.S. Department of Health and Human Services, Atlanta.
2. Agranoff, B. W., and Uhler, M. D. (1994). Learning and memory. In Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 5th ed. (G. J. Siegel et al., Eds.), pp. 1025-1042. Raven Press, New York.
3. American Academy of Pediatrics, Committee on Drugs. (1995). Treatment guidelines for lead exposure in children. Pediatrics 96(1), 155-160.
4. Angle, C. R. (1993). Children lead poisoning and its treatment. Annu. Rev. Pharmacol. Toxicol. 32, 409-434.
5. Aposhian, H. V. (1983). DMSA and DMPS - Water soluble antidotes for heavy metal poisoning. Annu. Rev. Pharmacol. Toxicol. 23, 193-215.
6. Aposhian, H. V., Carter, D. E., Hoover, T. D., Hsu, C. H., Maiorino, R. M., and Stine, E. (1984). DMSA, DMPS, and DMPA as arsenic antidotes. Fundam. Appl. Toxicol. 4, 58-70.
7. Bellinger, D., and Needleman, H. L. (1992). Neurodevelopmental effects of low-level lead exposure in children. In Human Lead Exposure (H. L. Needleman, Ed.), pp. 191-208. CRC Press, Boca Raton, FL.
8. Besunder, J. B., Anderson, R. L., and Super, D. M. (1995). Short-term efficacy of oral dimercaptosuccinic acid in children with low to moderate lead intoxication. Pediatrics 96(4 Pt. 1), 683-687.
9. Burdette, L. J., and Goldstein, R. (1986). Long-term behavioral and electrophysiological changes associated with lead exposure at different stages of brain development in the rat. Dev. Brain Res. 29, 101-110.
10. Cantilena, L. R., Jr., and Klaassen, C. D. (1982). The effect of chelating agents on the excretion of endogenous metals. Toxicol. Appl. Pharmacol. 63, 344-350.
11. Chisolm, J. J., Jr. (1990). Evaluation of the potential role of chelation therapy in treatment of low to moderate lead exposures. Environ. Health Perspect. 89, 67-74.
12. Collins, M. F., Hrdina, P. D., Whittle, E., and Singhal, R. L. (1982). Lead in blood and brain regions of rats chronically exposed to low doses of the metal. Toxicol. Appl. Pharmacol. 65, 314-322.
13. Cory-Slechta, D. A., Weiss, B., and Cox, C. (1985). Performance and exposure indices of rats exposed to low concentrations of lead. Toxicol. Appl. Pharmacol. 78(2), 291-299.
14. Cory-Slechta, D. A. (1988). Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy. J. Pharmacol. Exp. Ther. 246(1), 84-91.
15. Cory-Slechta, D. A., and Weiss, B. (1989). Efficacy of the chelating agent CaEDTA in reversing lead-induced changes in behavior. Neurotoxicology 10(4), 685-697.
16. David, O. J., Katz, S., Arcoleo, C. G., and Clark, J. (1985). Chelation therapy in children as treatment of sequelae in severe lead toxicity. Arch. Environ. Health 40(2), 109-113.
17. Dixon, W. J. (1992). BMDP Statistical Software Manual, Vol 2, pp. 1311-1352. University of California Press, Berkeley, CA.
18. Dixon, W. J., and Merdian, K. L. (1992). ANOVA and Regression with BMDP 5V. Dixon Statistical Associates, Los Angeles.
19. Dubas, T. C., and Hrdina, P. D. (1978). Behavioral and neurochemical consequences of neonatal exposure to lead in rats. J. Environ. Pathol. Toxicol. 2(2), 471-484.
20. Evans, H. L., Bushnell, P. J., Taylor, J. D., Monico, A., Teal, J. J., and Pontecorvo, M. J. (1986). A system for assessing toxicity of chemicals by continuous monitoring of homecage behaviors. Fundam. Appl. Toxicol. 6, 721-732.
21. Evans, H. L. (1989). Behaviors in the home cage reveal toxicity: Recent findings and proposals for the future. J. Am. Coll. Toxicol. 8(1), 35-52.
22. Evans, H. L., Daniel, S. A., and Marmor, M. (1994). Reversal learning tasks may provide rapid determination of cognitive deficits in lead-exposed children. Neurotoxicol. Teratol. 16(5), 471-477.
23. Evans, H. L. (1994). Neurotoxicity expressed in naturally occurring behavior. In Toxicological Interpretation of Neurobehavioral Data (Weiss, B., and O'Donoghue, J., Eds.), pp. 111-135. Raven Press, New York.
24. Ewan, K. B. R., and Pamphlett, R. (1996). Increased inorganic mercury in spinal motor neurons following chelating agents. Toxicology 17(2), 343-350.
25. Ferguson, S. A., and Bowman, R. E. (1992). Effects of arecoline and scopolamine on open field behavior of adult monkeys treated with lead during the first year postpartum. Neurotoxicol. Teratol. 14(1), 73-80.
26. Flora, S. J. S., Bhattacharya, R., and Vijayaraghavan, R. (1995). Combined therapeutic potential of meso-2,3-dimercaptosuccinic acid and calcium disodium edetate on the mobilization and distribution of lead in experimental lead intoxication in rats. Fundam. Appl. Toxicol. 25, 233-240.
27. Gong, Z. L., Little, A. R., El-Fawal, H. A. N., and Evans, H. L. (1995). Trimethyl lead induces biphasic changes in glial fibrillary acidic protein (GFAP) in the rat brain. Arch. Ind. Hyg. Toxicol. 46(4), 381-390.
28. Graziano, J. H., Leong, J. K., and Friedheim, E. (1978a). 2,3-demercaptosuccinic acid: A new agent for the treatment of lead poisoning. J. Pharmacol. Exp. Ther. 206, 696-700.
29. Graziano, J. H., Cuccia, D., and Friedheim, E. (1978b). The pharmacology of 2,3-demercaptosuccinic acid and its potential use in arsenic poisoning. J. Pharmacol. Exp. Ther. 207(3), 1051-1055.
30. Graziano, J. H., Lolacono, N. J., and Meyer, P. (1988). Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations. J. Pediatr. 113(4), 751-757.
31. Graziano, J. H., Lolacono, N. J., Moulton, T., Mitchell, M. E., Slavkovich, V., and Zarate, C. (1992). Controlled study of 2,3-dimercaptosuccinic acid for the management of childhood lead intoxication. J. Pediatr. 120, 133-139.
32. Hammond, P. B., Minnema, D. J., and Succop, P. A. (1993). Reversibility of lead-induced depression of growth. Toxicol. Appl. Pharmacol. 123(1), 9-15.
33. Hammond, P. B., and Succop, P. A. (1995). Effects of supplemental nutrition on lead-induced depression of growth and food consumption in weanling rats. Toxicol. Appl. Pharmacol. 131(1), 80-84.
34. Harry, G. J., Schmitt, T. J., Gong, Z. L., Brown, H., Zawia, N., and Evans, H. L. (1996). Lead-induced alterations of glial fibrillary acidic protein (GFAP) in the developing rat brain. Toxicol. Appl. Pharmacol. 139, 84-93.
35. Jones, M. M. (1991). New developments in therapeutic chelating agents as antidotes for metal poisoning. Toxicology 21(3), 209-233.
36. Jones, M. M., Basinger, M. A., Gale, G. R., Atkins, L. M., Smith, A. B., and Stone, A. (1994). Effect of chelate treatments on kidney, bone and brain lead levels of lead-intoxicated mice. Toxicology 89(2), 91-100.
37. Kapoor, S. C., Wielopolski, L., Graziano, J. H., and Lolacono, N. (1990). Influence of 2,3-demercaptosuccinic acid on gastrointestinal lead absorption and whole-body lead retention. Toxicol. Appl. Pharmacol. 97, 525-529.
38. Leviton, A., Bellinger, D., Pagano, M., and Rabinowits, M. (1995). Models of delayed recovery. J. Child Neurol. 10, 385-391.
39. Lilienthal, H., Winneke, G., Brockhaus, A., and Molik, B. (1986). Pre- and postnatal lead-exposure in monkeys: Effects on activity and learning set formation. Neurobehav. Toxicol. Teratol. 8, 265-272.
40. Lindh, U., Conradi, N. G., and Sourander, P. (1989). Distribution of lead in the cerebellum of suckling rats following low and high dose lead exposure, A micro-PIXE analysis. Acta Neuropathol. 79, 149-153.
41. Llobet, J. M., Domingo, J. L., Paternain, J. L., and Corbella, J. (1990). Treatment of acute lead intoxication. A quantitative comparison of a number of chelating agents. Arch. Environ. Contain. Toxicol. 19, 185-189.
42. Minnema, D. J., and Hammond, P. B. (1994). Effect of lead exposure on patterns of food intake in weanling rats. Neurotoxicol. Teratol. 16(6), 623-629.
43. Oberley, T. D., Friedman, A. L., Moser, R., and Siegel, F. L. (1995). Effects of lead administration on developing rat kidney. II. Functional, morphologic, and immunohistochemical studies. Toxicol. Appl. Pharmacol. 131(1), 94-107.
44. O'Callaghan, J. P. (1988). Neurotypic and gliotypic proteins as biochemical markers of neurotoxicity. Neurotoxicol. Teratol. 10, 445-452.
45. O'Callaghan, J. P. (1991). Quantification of glial fibrillary acidic protein: Comparison of slot-immunobinding assays with a novel sandwich ELISA. Neurotoxicol. Teratol. 13, 275-281.
46. Pappas, J. B., Ahlquist, J. T., Allen, E. M., and Banner, W. Jr. (1995). Oral dimercaptosuccinic acid and ongoing exposure to lead: Effects on heme synthesis and lead distribution in a rat model. Toxicol. Appl. Pharmacol. 133, 121-129.
47. Peele, D. B., Farmer, J. D., and MacPhail, R. C. (1987). Conditioned flavor aversions: Application in assessing the efficacy of chelators in the treatment of heavy-metal toxicity. Toxicol. Appl. Pharmacol. 88, 397-410.
48. Rao, G. N. (1996). New diet (NTP-2000) for rats in the National Toxicology Program toxicity and carcinogenicity studies. Fundam. Appl. Toxicol. 32, 102-108.
49. Ruff, H. A., Bijur, P. E., Markowitz, M., Ma, Y. C., and Rosen, J. F. (1993). Declining blood lead levels and cognitive changes in moderately lead-poisoned children. JAMA 269(13), 1641-1646.
50. Smith, D. R., and Flegal, A. R. (1992). Stable isotopic tracers of lead mobilized by DMSA chelation in low lead-exposed rats. Toxicol. Appl. Pharmacol. 116(1), 85-91.
51. Smith, D. R., Markowitz, M. E., Crick, J., Rosen, J. F., and Flegal, A. R. (1994). The effects of succimer on the absorption of lead in adults determined by using the stable isotope 204Pb. Environ. Res. 67(1), 39-53.
52. Stewart, P. W., Burright, R. G., and Donovick, P. J. (1995). DMSA chelation during co-exposure to lead: Increased locomotor activity in lead-exposed mice but not control. Physiol. Behav. 57(5), 863-867.
53. Thompson, R. F., Donegan, N. H., and Lavond, D. G. (1988). The psychobiology of learning and memory. In Stevens' Handbook of Experimental Psychology, second ed., Vol. 2 (R. C. Atkinsons, R. J. Herrnstein, G. Lindzey, and R. D. Luce, Eds.), pp. 245-347. Wiley, New York.
54. Tiffany-Castiglioni, E., Sierra, E. M., Wu, J. N., and Rowles, T. K. (1989). Lead toxicity in neuroglia. Neurotoxicology 10, 417-444.
55. Tiffany-Castiglioni, E., Legare, M. E., Schneider, L. A., Hanneman, W. H., Zenger, E., and Hong, S. J. (1996). Astroglia and lead neurotoxicity. In The Role of Glia in Neurotoxicity (M. Aschner and H. K. Kimelberg, Eds.), pp 175-200. CRC Press, Boca Raton, FL.
56. Verebey, K., Eng, Y. M., Davidow, B., and Ramon, A. (1991). Rapid, sensitive micro blood lead analysis: A mass screening technique for lead poisoning. J. Anal. Toxicol. 15(5), 237-240.
57. Verebey, K., Rosen, J. F., Schonfeld, D. J., Carriero, D., Eng, Y. M., Deutsch, J., Reimer, S., and Hogan, J. (1995). Blood collection and analytical considerations in blood lead screening in children. Clin. Chem. 41, 469-470.
58. Widzowski, D. V., Finkelstein, J. N., Pokora, M. J., and Cory-Slechta, D. A. (1994). Time course of postnatal lead-induced changes in dopamine receptors and their relationship to changes in dopamine sensitivity. Neurotoxicology 15(4), 853-865.
59. Wigfield, D. C., Chakrabarti, C. L., Wright, S. C., Eastwood, J. A., and Karkowska, R. (1986). Chemical and biological monitoring of chronic lead poisoning in the rat. Implications to the assessment of hazard of low-level lead. J. Appl. Toxicol. 6(5), 371-376.
60. Wilson, A., Brooks, D. C., and Bouton, M. E. (1995). The role of the rat hippocampal system in several effects of context in extinction. Behav. Neurosci. 109(5), 828-836.
61. Winneke, G., Brockhaus, A., and Baltissen, R. (1977). Neurobehavioral and systemic effects of long term blood lead-elevation in rats. I. Discrimination learning and open field-behavior. Arch. Toxicol. 37(4), 147-163.
62. Yamamoto, B. K., and Kutscher, C. L. (1981). Drug and food-deprivation modulation of activity in rats given chronic dietary lead: Significance of type of activity measure. Pharmacol. Biochem. Behav. 15, 505-512.