Immunodetection and quantitation of imidazoline receptor proteins in platelets of patients with major depression and in brains of suicide victims

Archives of General Psychiatry

Volumn 53, Issue 9, 1996, Pages 803-810

  García Sevilla, Jesus A ^a,b   Escribá, Pablo V ^b   Sastre, Magdalena ^b   Walzer, Claude ^a   Busquets, Xavier ^b   Jaquet, Galina ^a   Reis, Donald J ^c   Guimón, José ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; IMIDAZOLINE RECEPTOR; RECEPTOR PROTEIN;

ADULT; AGED; ARTICLE; BRAIN MEMBRANE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DEPRESSION; HUMAN; HUMAN TISSUE; NORADRENALIN RELEASE; PROTEIN FAMILY; RECEPTOR DENSITY; SUICIDE; THROMBOCYTE;

EID: 0029829208     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.1996.01830090049008     Document Type: Article

References (65)

1. 1adrenoceptor agonis: binding sites in the hippocampus and frontal cortex of depressed suicide victims. J Neurochem. 1994;63:256-265.
2. 1-adrenoceptors is elevated in the locus coeruleus from suicide victims. J Neurochem. 1994;63:617-624.
3. 1-adrenoceptors in major affective disorder effect of long-term lithium carbonate treatment. Arch Gen Psychiatry. 1986;43:51-57.
4. 3H](-)adrenaline to platelets of depressed patients with melancholia: effect of long-term clomipramine treatment. Acta Psychiatr Scand. 1987;75:150-157.
5. Mori H, Koyama T, Yamasuita I. Platelet alpha-2 adrenergic receptor-mediated phosphoinositide responses in endogenous depression. Life Sci. 1991;48:741-748.
6. Piletz JE, Halaris A, Saran A, Marler M. Desipramine lowers tritiated paraaminoclonidme binding in platelets of depressed patients. Arch Gen Psychiatry. 1991;48:813-820
7. 1-Adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression. Biol Psychiatry. 1992;31:471-490.
8. 2A-subtype J Neurochem 1994;63:1077-1085.
9. Michel MC, Insel PA. Are there multiple imidazoline binding sites? Trends Pharmacol Sci. 1989;10:342-344.
10. Michel MC, Ernsberger P. Keeping an eye on the I site: imidazoline-preferring receptors. Trends Pharmacol Sci. 1992;13:369-370.
11. 1-imidazoline sites. J Pharmacol Exp Ther. 1993;264:172-182.
12. 3H]RX821002 (2-methoxy idazoxan) in the human and rat brains J Pharmacol Exp Ther. 1993;264:1187-1197
13. Li G, Regunathan S, Barrow CJ, Eshraghi J, Cooper R, Reis DJ. Agmatine: an endogenous clonidine-displacing substance in the brain. Science. 1994;263:966-969
14. Atlas D. Identifying clonidine-displacing substance. Science. 1994;266:462-463.
15. Bousquet P, Feldman J, Schwartz J. Central cardiovascular effects of α-adrenergic drugs: differences between catecholamines and imidazolines. J Pharmacol Exp Ther. 1984;230:232-242.
16. 1-imidazoline receptors in the rostral ventrolateral medulla. J Cardiovasc Pharmacol. 1994;24(suppl 1):S1-S8.
17. Tibiriça E, Feldman J, Mermet C, Gomon F, Bousquet P. An imidazoline specific mechanism for the hypotensive effect of clonidine: a study with yohimbine and idazoxan. J Pharmacol Exp Ther. 1991;256:606-613.
18. 2-adrenoceptor-independent inhibition of noradrenalme release by imidazoline derivatives. Naunyn Schmiedebergs Arch Pharmacol. 1991;343:271-282.
19. Molderings GJ, Hentrich F, Göthert M. Pharmacological characterization of the imidazoline receptor which mediates inhibition of noradrenaline in the rabbit pulmonary artery. Naunyn Schmiedebergs Arch Pharmacol. 1991;344:630-638.
20. 2-adrenoceptors do not regulate catecholamine secretion by bovine adrenal medullary cells: a study with clonidine. Mol Pharmacol 1986;29:134-143.
21. Tesson F, Parini A. Identification of an imidazoline-guanidinium receptive site in mitochondria from rabbit cerebral cortex. Eur J Pharmacol. 1991;208:81-83.
22. 2 with monoamine oxidase-B sites J Neurochem 1993;61:881-889.
23. Regunathan S, Feinstein DL, Reis DJ. Expression of non-adrenergic imidazoline sites in rat cerebral cortical astrocytes. J Neurosci Res. 1993;34:681-688.
24. Olmos G, Alemany R, Escribá PV, Garcia-Sevilla JA. The effects of chronic imidazoline drug treatment on glial fibrillary acidic protein concentrations in rat brain. Br J Pharmacol. 1994;111:997-1002.
25. 3H-imidazoline sites) are increased in postmortem brain from patients with Alzheimer's disease. Neurosci Lett. 1993;160:109-112.
26. 2imidazoline receptors in the healthy and pathologic human brain. Ann N Y Acad Sci. 1995;763:178-193.
27. Escribá PV, Sastre M, Wang H, Regunathan S, Reis DJ, García-Sevilla JA. Immunodetection of putative imidazoline receptor proteins in the human and rat brain and other tissues. Neurosci Lett. 1994;178:81-84.
28. 3H]clonidine. Neurochem Int. 1994;25: 183-191.
29. Limon I, Coupry I, Lanier SM, Parini A. Purification and characterization of mitochondnal imidazoline-guanidinium receptive sites from rabbit kidney. J Biol Chem. 1992;267:21645-21649.
30. Wang H, Regunathan S, Meeley MP, Reis DJ. Isolation and characterization of imidazoline receptor proteins from bovine adrenal chromaffin cells. Mol Pharmacol. 1992;42:792-801.
31. Lanier SM, Ivkovic B, Singh I, Neumeyer JL, Bakthavachalam V. Visualization of multiple imidazoline/guanidinium-receptive sites. J Biol Chem. 1993;268:16047-16051.
32. Ivkovic B, Bakthavachalam V, Zhang W, Parini A, Diz D, Bosch S, Neumeyer JL, Lanier SM. Development of a high-affinity radioiodinated ligand for iden- Motion of imidazoline/guanidinium receptive sites (IGRS) intratissue distribution of IGRS in liver, forebrain, and kidney. Mol Pharmacol. 1994;46:15-23.
33. Diamant S, Eldar-Geva T, Atlas D. Imidazoline binding sites in human placenta: evidence for heterogeneity and a search for physiological function. Br J Pharmacol. 1992;106:101-108.
34. 3H idazoxan binding sites (l-receptors) occurs to interacting or interconvertible affinity forms of the receptor Pharmacol Toxicol. 1992;70:208-219.
35. 3H]idazoxan Neurosci Lett 1995;184:133-136.
36. Piletz JE, Sletten K. Nonadrenergic imidazoline binding sites on human piatelets. J Pharmacol Exp Ther. 1993;267:1493-1502.
37. 2adrenergic receptors. Mol Pharmacol. 1990;37:65-68.
38. 1-adrenoceptor? Eur J Pharmacol. 1990;190: 203-215
39. Piletz JE, Sletten KR, Halaris AE. Imidazolme-preferring binding sites in human platelets: plasma membrane subtype I, is elevated in mood disorders. Fundam Clin Pharmacol. 1992;6(suppl 1):49S.
40. 3H]idazoxan binding sites in the frontal cortex of depressed suicide victims Biol Psychiatry. 1993;34:498-501
41. 3H]idazoxan binding sites in the rat brain. Br J Pharmacol. 1993;108:597-603.
42. 2 imidazoline-preferring receptors. Br J Pharmacol. 1995;114:837-845
43. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62
44. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH. Measurement of protein using bicinchoninic acid. Anal Biochem. 1985;150:76-85.
45. Wang H, Regunathan S, Ruggiero DA, Reis DJ. Production and characterization of antibodies specific for imidazoline receptor protein. Mol Pharmacol. 1993;43:509-515
46. Escribá PV, Sastre M, García-Sevilla JA. Increased density of guanine nucleotide-binding proteins in the postmortem brains of heroin addicts. Arch Gen Psychiatry. 1994;51:494-501.
47. Gettys TW, Sheriff-Carter K, Moomaw J, Taylor IL, Raymond JR. Characterization and use of crude α-subunit preparations for quantitative immunoblotting of G proteins. Anal Biochem. 1994;220:82-91.
48. Escribá PV, Ozaita A, Miralles A, Reis DJ, García-Sevilla JA. Molecular characterization and isolation of a 45-kilodalton imidazoline receptor protein from the rat brain. Mol Brain Res 1995;32:187-196.
49. Greney M, Bennai F, Molines A, Belcourt A, Dontenwill M, Bousquet P. Isolation of a human cerebral imidazoline-spedfic binding protein. Eur J Pharmacol. 1994;265:R1-R2.
50. 2-adrenoceptor states plus a non-adrenergic site on human platelet plasma membranes. Biochem Pharmacol 1991;42:569-584.
51. 2-imidazolme receptors in the frontal cortex ot suicide victims Ann N Y Acad Sci 1995;763520-522.
52. 3H]-para-amino-clonidine binding to platelet purified plasma membranes from depressed patients. Neuropsychopharmacology. 1990;3:201-210.
53. 1-imidazoline receptors in mood disorders. Ann N Y Acad Sci. 1995;763:510-519.
54. Potter WZ, Manji HK. Catecholammes in depression: an update. Clin Chem. 1994;40:279-287
55. Schatzberg AF, Schildkraut JJ. Recent studies on norepinephrine systems in mood disorders. In Bloom FE, Kupfer DJ, eds. Psychopharmacology. 4th ed. New York, NY: Raven Press: 1995:911-920.
56. 2-adrenoceptors and putative imidazoline receptors on rabbit heart sympathetic nerves. Naunyn Schmierderbergs Arch Pharmacol. 1993;348:127-133.
57. 2-imidazoline binding sites. Naunyn Schmiedebergs Arch Pharmacol. 1995;351:507-516.
58. Raasch W, Regunathan S, Reis DJ. Agmatine, the bacterial amire, is widely distributed in mammalian tissues. Life Sci. 1995;56:2319-2330.
59. Piletz JE, Chikkala DN, Ernsberger P. Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors J Pharmacol Exp Ther. 1995;272:581-587.
60. 2-Adrenoceptor-independent inhibition by imidazolines and guanidines of noradrenaline release from peripheral, but not central noradrenergic neurons Ann N Y Acad Sci. 1995;763: 405-419.
61. 2 receptors. Mol Brain Res. 1994;27:337-341.
62. Cedarbaum JM, Aghajanian GK. Noradrenergic neurons of the locus caeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane. Brain Res. 1976;112:413-419
63. Pineda J, Ugedo L, García-Sevilla JA. Stimulatory effects of clonidne cirazoline and ilmenidine on locus coeruleus noradrenergic neurones: possible involvement of imidazoline-preferring receptors. Naunyn Schmiedebergs Arch Pharmacol. 1993;348:134-140.
64. Ruiz-Ortega JA, Ugedo L, Pineda J, García-Sevilla JA. The stimulatory effect of clonidme through irnidazoline receptors on locus coeruleus noradrenergic neurones is mediated by excitatory ammo acids and modulated by serotonin. Naunyn Schmierdebergs Arch Pharmacol. 1995;352:121-126.
65. Evinger MJ, Ernsberger P, Regunathan S, Reis DJ. Regulation of phenylethanolamine N-metyhyltransferase gene expression by imidazoline receptors in adrenal chromatfin cells. J Neurochem 1995;65:988-997.