Reduced apoptosis and increased deletion mutations at Aprt locus in vivo in mice exposed to repeated ionizing radiation

Cancer Research

Volumn 67, Issue 5, 2007, Pages 1910-1917

  Liang, Li ^a   Mendonca, Marc S ^b   Deng, Li ^a   Nguyen, Son C ^a   Shao, Changshun ^a   Tischfield, Jay A ^a  

^a RUTGERS UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; APRT GENE; ARTICLE; CARCINOGENESIS; CHROMOSOME DELETION; CONTROLLED STUDY; DELETION MUTANT; FEMALE; GENE LOCUS; GENE MUTATION; IN VIVO STUDY; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION EXPOSURE; REPORTER GENE; SPLEEN CELL; T LYMPHOCYTE; X RAY;

ADENINE PHOSPHORIBOSYLTRANSFERASE; ANIMALS; APOPTOSIS; FEMALE; GENE DELETION; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; RADIATION DOSAGE; RADIATION EFFECTS; RADIATION, IONIZING; SPLEEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33947238890     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1476     Document Type: Article

References (36)

1. Little JB. Radiation carcinogenesis. Carcinogenesis 2000;21:397-404.
2. Storer JB. Carcinogenic effects: an overview. In: Upton AC, Albert RE, Burns FJ, Shore RE, editors. Radiation Carcinogenesis. New York: Elsevier; 1986. p. 11-22.
3. Huang L, Snyder AR, Morgan WF. Radiation-induced genomic instability and its implications for radiation carcinogenesis. Oncogene 2003;22:5848-54.
4. Pfeiffer P, Goedecke W, Obe G. Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis 2000; 15:289-302.
5. Morgan WF. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat Res 2003;159:581-96.
6. Wright EG. Inherited and inducible chromosomal instability: a fragile bridge between genome integrity mechanisms and tumourigenesis. J Pathol 1999;187: 19-27.
7. Bernstein C, Bernstein H, Payne CM, Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat Res 2002;511:145-78.
8. Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004;432:316-23.
9. Gudkov AV, Komarova EA. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 2003;3:117-29.
10. Zhivotovsky B, Kroemer G. Apoptosis and genomic instability. Nat Rev Mol Cell Biol 2004;5:752-62.
11. Stambrook PJ, Shao C, Stockelman M, Boivin G, Engle SJ, Tischfield JA. APRT: a versatile in vivo resident reporter of local mutation and loss of heterozygosity. Environ Mol Mutagen 1996;28:471-82.
12. Shao C, Deng L, Henegariu O, et al. Mitotic recombination produces the majority of the recessive fibroblast variants in heterozygous mice. Proc Natl Acad Sci U S A 1999;96:9230-5.
13. Liang L, Deng L, Shao C, Stambrook PJ, Tischfield JA. In vivo loss of heterozygosity in T-cells of B6C3F1 Aprt(+/-) mice. Environ Mol Mutagen 2000;35:150-7.
14. Liang L, Shao C, Deng L, Mendonca MS, Stambrook PJ, Tischfield JA. Radiation-induced genetic instability in vivo depends on p53 status. Mutat Res 2002;502:69-80.
15. Jessberger R, Berg P. Repair of deletions and double-strand gaps by homologous recombination in a mammalian in vitro system. Mol Cell Biol 1991;11: 445-57.
16. Liang L, Deng L, Chen Y, Li GC, Shao C, Tischfield JA. Modulation of DNA end joining by nuclear proteins. J Biol Chem 2005;280:31442-9.
17. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
18. Liang L, Chen J, Vittal R, et al. Expression Profiling of Crystal-Induced Injury in Human Kidney Epithelial Cells. Nephron Physiol 2006;103:53-62.
19. Grdina DJ, Kataoka Y, Basic I, Perrin J. The radio-protector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation. Carcinogenesis 1992;13:811-4.
20. Lorenz R, Deubel W, Leuner K, Gollner T, Hochhauser E, Hempel K. Dose and dose-rate dependence of the frequency of HPRT deficient T lymphocytes in the spleen of the 137Cs γ-irradiated mouse. Int J Radiat Biol 1994;66:319-26.
21. Wijnhoven SW, Van Sloun PP, Kool HJ, et al. Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse. Proc Natl Acad Sci U S A 1998;95:13759-64.
22. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993;362:847-9.
23. Clarke AR, Purdie CA, Harrison DJ, et al. Thymocyte apoptosis induced by p53dependent and independent pathways. Nature 1993;362:849-52.
24. Lotem J, Sachs L. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 1993;82: 1092-6.
25. Lee JM, Bernstein A. p53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci U S A 1993;90:5742-6.
26. Hall EJ. Radiobiology for the radiologist. 4th ed. Philadelphia: JB Lippincott; 1994. p. 315-6.
27. Shieh SY, Ikeda M, Taya Y, Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 1997;91:325-34.
28. Siliciano JD. Canman CE, Taya Y, Sakaguchi K, Appella E, Kastan MB. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev 1997;11:3471-81.
29. Erlacher M, Michalak EM, Kelly PN, et al. BH3-only proteins Puma and Bim are rate-limiting for γ-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood 2005;106:4131-8.
30. Shao C, Deng L, Henegariu O, Liang L, Stambrook PJ, Tischfield JA. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proc Natl Acad Sci U S A 2000;97:7405-10.
31. Ponomareva ON, Rose JA, Lasarev M, Rasey J, Turker MS. Tissue-specific deletion and discontinuous loss of heterozygosity are signatures for the mutagenic effects of ionizing radiation in solid tissues. Cancer Res 2002;62: 1518-23.
32. Kaplan HS, Brown MB. A quantitative dose-response study of lymphoid-tuor develepment in irradiated C57 black mice. J Natl Cancer Inst 1952;13:185-208.
33. Saxena S, Dutta A. Geminin-Cdt1 balance is critical for genetic stability. Mutat Res 2005;569:111-21.
34. Coates PJ, Lorimore SA, Lindsay KJ, Wright EG. Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility? J Pathol 2003;201: 377-88.
35. Cherbonnel-Lasserre C, Gauny S, Kronenberg A. Suppression of apoptosis by Bcl-2 or Bcl-xL promotes susceptibility to mutagenesis. Oncogene 1996; 13:1489-97.
36. Shimada Y, Nishimura M, Kakinuma S, et al. Radiation-associated loss of heterozygosity at the Znfn1a1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas. Radiat Res 2000;154:293-300.