Heterologous production and secretion of Clostridium perfringens β-toxoid in closely related Gram-positive hosts

Journal of Biotechnology

Volumn 127, Issue 3, 2007, Pages 361-372

  Nijland, Reindert ^a   Lindner, Cordula ^a   van Hartskamp, Mariska ^a   Hamoen, Leendert W ^a   Kuipers, Oscar P ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Bacillus subtilis; Clostridium perfringens toxin; Heterologous protein expression; Lactococcus lactis; Protein secretion; rpsF promoter; Vaccine production

Indexed keywords

DETOXIFICATION; GENETIC ENGINEERING; IMMUNOLOGY; TOXIC MATERIALS; VACCINES;

BACILLUS SUBTILIS; CLOSTRIDIUM PERFRINGENS Β-TOXIN; HETEROLOGOUS PROTEIN EXPRESSION; LACTOCOCCUS LACTIS; PROTEIN SECRETION; RPSF PROMOTERS; VACCINE PRODUCTION;

BACTERIA;

BETA TOXOID; CLOSTRIDIUM TOXIN; PROTEIN S6; RIBOSOME PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CLOSTRIDIUM PERFRINGENS; COMPARATIVE STUDY; CONTROLLED STUDY; COST; DETOXIFICATION; DRUG DOSE TITRATION; DRUG SAFETY; FEMALE; GENE EXPRESSION SYSTEM; GRAM POSITIVE ASPOROGENOUS ROD-SHAPED BACTERIA; HOST; IMMUNIZATION; IMMUNOGENICITY; INTRACELLULAR SPACE; LACTOCOCCUS LACTIS; LD 50; MOLECULAR CLONING; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; STREPTOCOCCUS PNEUMONIAE; VACCINE PRODUCTION;

BACTERIAL PROTEINS; BACTERIAL VACCINES; CLOSTRIDIUM PERFRINGENS; GENE EXPRESSION; GRAM-POSITIVE BACTERIA; PLASMIDS; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; TOXOIDS;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); CLOSTRIDIUM PERFRINGENS; LACTOCOCCUS LACTIS; POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 33947226554     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2006.07.014     Document Type: Article

References (42)

1. Anagnostopoulos C., and Spizizen J. Requirements for transformation in Bacillus subtilis. J. Bacteriol. 81 (1961) 741-746
2. Avery O.T., MacLeod C.M., and McCarty M. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J. Exp. Med. 79 (1944) 137-158
3. Biaudet V., Samson F., and Bessieres P. Micado-a network-oriented database for microbial genomes. Comput. Appl. Biosci. 13 (1997) 431-438
4. Braun P., Gerritse G., van Dijl J.M., and Quax W.J. Improving protein secretion by engineering components of the bacterial translocation machinery. Curr. Opin. Biotechnol. 10 (1999) 376-381
5. Bron S., and Venema G. Ultraviolet inactivation and excision-repair in Bacillus-subtilis. 1. Construction and characterization of A transformable eightfold auxotrophic strain and 2 ultraviolet-sensitive derivatives. Mutat. Res. 15 (1972) 1-8
6. Darmon E., Noone D., Masson A., Bron S., Kuipers O.P., Devine K.M., and Dijl J.M.V. A Novel class of heat and secretion stress-responsive genes is controlled by the autoregulated CssRS two-component system of Bacillus subtilis. J. Bacteriol. 184 (2002) 5661-5671
7. de Ruyter P.G., Kuipers O.P., and de Vos W.M. Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin. Appl. Environ. Microbiol. 62 (1996) 3662-3667
8. Gasson M.J. Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. J. Bacteriol. 154 (1983) 1-9
9. Gill D.M. Bacterial toxins: a table of lethal amounts. Microbiol. Rev. 46 (1982) 86-94
10. Harwood C.R. Bacillus subtilis and its relatives: molecular biological and industrial workhorses. Trends Biotechnol. 10 (1992) 247-256
11. Hunter S.E., Brown J.E., Oyston P.C., Sakurai J., and Titball R.W. Molecular genetic analysis of beta-toxin of Clostridium perfringens reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus. Infect. Immun. 61 (1993) 3958-3965
12. Hyyrylainen H.L., Bolhuis A., Darmon E., Muukkonen L., Koski P., Vitikainen M., Sarvas M., Pragai Z., Bron S., van Dijl J.M., and Kontinen V.P. A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress. Mol. Microbiol. 41 (2001) 1159-1172
13. Kraus A., Hueck C., Gartner D., and Hillen W. Catabolite repression of the Bacillus subtilis xyl operon involves a cis element functional in the context of an unrelated sequence, and glucose exerts additional xylR-dependent repression. J. Bacteriol. 176 (1994) 1738-1745
14. Kuipers O.P., de Ruyter P.G., Kleerebezem M., and de Vos W.M. Quorum sensing-controlled gene expression in lactic acid bacteria. J. Biotech. 64 (1998) 15-21
15. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
16. Leenhouts K.J., Kok J., and Venema G. Campbell-like integration of heterologous plasmid DNA into the chromosome of Lactococcus lactis subsp. lactis. Appl. Environ. Microbiol. 55 (1989) 394-400
17. Leloup L., Haddaoui E.A., Chambert R., and Petit-Glatron M.F. Characterization of the rate-limiting step of the secretion of Bacillus subtilis alpha-amylase overproduced during the exponential phase of growth. Microbiology 143 (1997) 3295-3303
18. Li W., Zhou X., and Lu P. Bottlenecks in the expression and secretion of heterologous proteins in Bacillus subtilis. Res. Microbiol. 155 (2004) 605-610
19. Lindner C., Nijland R., van H.M., Bron S., Hamoen L.W., and Kuipers O.P. Differential expression of two paralogous genes of Bacillus subtilis encoding single-stranded DNA binding protein. J. Bacteriol. 186 (2004) 1097-1105
20. Miller J.H. Experiments in Molecular Genetics (1982), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
21. Mierau I., Leij P., van S.I., Blommestein B., Floris E., Mond J., and Smid E.J. Industrial-scale production and purification of a heterologous protein in Lactococcus lactis using the nisin-controlled gene expression system NICE: the case of lysostaphin. Microb. Cell Fact. 4 (2005) 15
22. Mierau I., Olieman K., Mond J., and Smid E.J. Optimization of the Lactococcus lactis nisin-controlled gene expression system NICE for industrial applications. Microb. Cell Fact. 4 (2005) 16
23. Moszer I., Glaser P., and Danchin A. SubtiList: a relational database for the Bacillus subtilis genome. Microbiology 141 Pt. 2 (1995) 261-268
24. Noone D., Howell A., and Devine K.M. Expression of ykdA, encoding a Bacillus subtilis homologue of HtrA, is heat shock inducible and negatively autoregulated. J. Bacteriol. 182 (2000) 1592-1599
25. Norton P.M., Brown H.W.G., and Le Page R.W.F. The immune response to Lactococcus lactis: implications for its use as a vaccine delivery vehicle. FEMS Microbiol. Lett. 120-123 (1994) 249-256
26. O'Sullivan D.J., and Klaenhammer T.R. High- and low-copy-number Lactococcus shuttle cloning vectors with features for clone screening. Gene 137 (1993) 227-231
27. Pallen M.J., and Wren B.W. The HtrA family of serine proteases. Mol. Microbiol. 26 (1997) 209-221
28. Pozzi G., Masala L., Iannelli F., Manganelli R., Havarstein L.S., Piccoli L., Simon D., and Morrison D.A. Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: two allelic variants of the peptide pheromone. J. Bacteriol. 178 (1996) 6087-6090
29. Sambrook J., Fritsch E.F., and Maniatis T. Molecular Cloning: A Laboratory Manual (1989), Cold Spring Harbour Laboratory, Cold Spring Harbour, NY
30. Schallmey M., Singh A., and Ward O.P. Developments in the use of Bacillus species for industrial production. Can. J. Microbiol. 50 (2004) 1-17
31. Segers, R.P.A.M., Waterfield, N.R., Frandsen, P.L., Wells, J.M. Clostridium perfringens vaccine [EP0892054]. 1999. EUR. Ref Type: Patent.
32. Songer J.G. Clostridial enteric diseases of domestic animals. Clin. Microbiol. Rev. 9 (1996) 216-234
33. Spizizen J. Transformation of biochemically deficient strains of Bacillus subtilis by deoxyribonucleate. Proc. Natl. Acad. Sci. U. S. A 44 (1958) 1072-1078
34. Springer S., and Selbitz H.J. The control of necrotic enteritis in sucking piglets by means of a Clostridium perfringens toxoid vaccine. FEMS Immunol. Med. Microbiol. 24 (1999) 333-336
35. Steinthorsdottir V., Fridriksdottir V., Gunnarsson E., and Andresson O.S. Site-directed mutagenesis of Clostridium perfringens beta-toxin: expression of wild-type and mutant toxins in Bacillus subtilis. FEMS Microbiol. Lett. 158 (1998) 17-23
36. Steinthorsdottir V., Halldorsson H., and Andresson O.S. Clostridium perfringens beta-toxin forms multimeric transmembrane pores in human endothelial cells. Microb. Pathog. 28 (2000) 45-50
37. Terzaghi B.E., and Sandine W.E. Improved medium for lactic streptococci and their bacteriophages. Appl. Microbiol. 29 (1975) 807-813
38. Tjalsma H., Bolhuis A., Jongbloed J.D., Bron S., and van Dijl J.M. Signal peptide-dependent protein transport in Bacillus subtilis: a genome-based survey of the secretome. Microbiol. Mol. Biol. Rev. 64 (2000) 515-547
39. Veening J.W., Smits W.K., Hamoen L.W., Jongbloed J.D.H., and Kuipers O.P. Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis. Appl. Environ. Microbiol. 70 (2004) 6809-6815
40. Vitikainen M., Pummi T., Airaksinen U., Wahlstrom E., Wu H., Sarvas M., and Kontinen V.P. Quantitation of the capacity of the secretion apparatus and requirement for PrsA in growth and secretion of alpha-amylase in Bacillus subtilis. J. Bacteriol. 183 (2001) 1881-1890
41. Westers H., Darmon E., Zanen G., Veening J.W., Kuipers O.P., Bron S., Quax W.J., and van Dijl J.M. The Bacillus secretion stress response is an indicator for alpha-amylase production levels. Lett. Appl. Microbiol. 39 (2004) 65-73
42. Wu S.C., Yeung J.C., Duan Y., Ye R., Szarka S.J., Habibi H.R., and Wong S.L. Functional production and characterization of a fibrin-specific single-chain antibody fragment from Bacillus subtilis: effects of molecular chaperones and a wall-bound protease on antibody fragment production. Appl. Environ. Microbiol. 68 (2002) 3261-3269