Genetic toxicity assessment: Employing the best science for human safety evaluation part II: Performances of the in vitro micronucleus test compared to the mouse lymphoma assay and the in vitro chromosome aberration assay

Toxicological Sciences

Volumn 96, Issue 2, 2007, Pages 214-217

  Lorge, Elisabeth ^a   Lambert, Carine ^a   Gervais, Véronique ^a   Becourt Lhote, Nathalie ^a   Delongeas, Jean Luc ^a   Claude, Nancy ^b  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^b IRIS Institut de Recherches Internationales Servier   (France)

Author keywords

Genotoxicity; In vitro micronucleus assay; In vitro tests

Indexed keywords

ANEUGEN; CARDIOVASCULAR AGENT; CENTRAL NERVOUS SYSTEM AGENTS; PSYCHOTROPIC AGENT;

ANIMAL CELL; ARTICLE; BIOASSAY; CHROMOSOME ABERRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; FALSE POSITIVE RESULT; GENOTOXICITY; IN VITRO STUDY; INTERMETHOD COMPARISON; LEUKEMIA L 5178 Y; METAPHASE; MICRONUCLEUS TEST; MOUSE; MULTINUCLEAR CELL; NONHUMAN; SAFETY; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING;

ANIMALS; CELL LINE, TUMOR; CHROMOSOME ABERRATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOXICITY; DRUGS, INVESTIGATIONAL; HUMANS; LYMPHOMA; MICE; MICRONUCLEUS TESTS; TOXICITY TESTS;

EID: 33947213309     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl193     Document Type: Article

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