-
1
-
-
30344465740
-
Regulation of CRE-dependent transcription by presenilins: Prospects for therapy of Alzheimer's disease
-
Beglopoulos V, Shen J (2006) Regulation of CRE-dependent transcription by presenilins: Prospects for therapy of Alzheimer's disease. Trends Pharmacol Sci 27: 33-40
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 33-40
-
-
Beglopoulos, V.1
Shen, J.2
-
2
-
-
33947201115
-
Loss of function presenilin mutations in Alzheimer disease
-
De Strooper B (2007) Loss of function presenilin mutations in Alzheimer disease. EMBO reports 8: 141-146
-
(2007)
EMBO Reports
, vol.8
, pp. 141-146
-
-
De Strooper, B.1
-
3
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391: 387-390
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
4
-
-
0038664363
-
Reconstitution of γ-secretase activity
-
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C (2003) Reconstitution of γ-secretase activity. Nat Cell Biol 5: 486-488
-
(2003)
Nat Cell Biol
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
5
-
-
0027333557
-
Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
-
Haass C, Selkoe DJ (1993) Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell 75: 1039-1042
-
(1993)
Cell
, vol.75
, pp. 1039-1042
-
-
Haass, C.1
Selkoe, D.J.2
-
6
-
-
33646483640
-
Electron microscopic structure of a purified active γ secretase reveals an aqueous intramembranous chamber and two pores
-
Lazarov VK, Fraering PC, Ye W, Wolfe MS, Selkoe DJ (2006) Electron microscopic structure of a purified active γ secretase reveals an aqueous intramembranous chamber and two pores. Proc Natl Acad Sci USA 103: 16889-16894
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16889-16894
-
-
Lazarov, V.K.1
Fraering, P.C.2
Ye, W.3
Wolfe, M.S.4
Selkoe, D.J.5
-
7
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
Levitan D, Greenwald I (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377: 351-354
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
8
-
-
0036364359
-
The solved and unsolved mysteries of the genetics of early-onset Alzheimer's disease
-
Rogaeva E (2002) The solved and unsolved mysteries of the genetics of early-onset Alzheimer's disease. Neuromolecular Med 2: 1-10
-
(2002)
Neuromolecular Med
, vol.2
, pp. 1-10
-
-
Rogaeva, E.1
-
9
-
-
33645846948
-
A partial failure of membrane protein turnover may cause Alzheimer's disease: A new hypothesis
-
Sambamurti K, Suram A, Venugopal C, Prakasam A, Zhou Y, Lahiri DK, Greig NH (2006) A partial failure of membrane protein turnover may cause Alzheimer's disease: A new hypothesis. Curr Alzheimer Res 3: 81-90
-
(2006)
Curr Alzheimer Res
, vol.3
, pp. 81-90
-
-
Sambamurti, K.1
Suram, A.2
Venugopal, C.3
Prakasam, A.4
Zhou, Y.5
Lahiri, D.K.6
Greig, N.H.7
-
10
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D et al (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2: 864-870
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
-
11
-
-
33748746861
-
Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway
-
Spasic D, Tolia A, Dillen K, Baert V, De Strooper B, Vrijens S, Annaert W (2006) Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. J Biol Chem 281: 26569-26577
-
(2006)
J Biol Chem
, vol.281
, pp. 26569-26577
-
-
Spasic, D.1
Tolia, A.2
Dillen, K.3
Baert, V.4
De Strooper, B.5
Vrijens, S.6
Annaert, W.7
-
12
-
-
33947242870
-
When loss is gain: Reduced presenilin proteolytic function leads to increased Aβ42/Aβ40
-
Wolfe MS (2007) When loss is gain: Reduced presenilin proteolytic function leads to increased Aβ42/Aβ40. EMBO reports 8: 136-140
-
(2007)
EMBO Reports
, vol.8
, pp. 136-140
-
-
Wolfe, M.S.1
-
13
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 398: 513-517
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
|