Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha

Food and Chemical Toxicology

Volumn 42, Issue 12, 2004, Pages 2015-2020

  Kaur, K ^a   Rani, G ^b   Widodo, Nashi ^a   Nagpal, A ^b   Taira, K ^a   Kaul, S C ^a   Wadhwa, R ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b GURU NANAK DEV UNIVERSITY   (India)

Author keywords

Ashwagandha; Growth arrest; Human tumorgenic cells; Leaf extract; Senescence

Indexed keywords

GLUCOSE; HYDROGEN PEROXIDE; WITHANIA SOMNIFERA EXTRACT;

ANTIOXIDANT ACTIVITY; ARTICLE; CARCINOGENIC ACTIVITY; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; HUMAN; HUMAN CELL; OXIDATION; STATISTICAL SIGNIFICANCE; TUMOR CELL; WITHANIA SOMNIFERA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; CELL AGING; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; HUMANS; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; OXIDANTS; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT LEAVES; WITHANIA;

WITHANIA; WITHANIA SOMNIFERA;

EID: 7044220551     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2004.07.015     Document Type: Article

References (35)

1. R. Agarwal, S. Diwanay, P. Patki, and B. Patwardhan Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation J. Ethnopharmacol. 67 1999 27 35
2. M.A. Akbarsha, S. Vijendrakumar, B. Kadalmani, R. Girija, and A. Faridha Curative property of Withania somnifera Dunal root in the context of carbendazim-induced histopathological changes in the liver and kidney of rat Phytomedicine 7 2000 499 507
3. M.K. al-Hindawi, S.H. al-Khafaji, and M.H. Abdul-Nabi Anti-granuloma activity of Iraqi Withania somnifera J. Ethnopharmacol. 37 1992 113 116
4. R. Archana, and A. Namasivayam Antistressor effect of Withania somnifera J. Ethnopharmacol. 64 1999 91 93
5. M.J. Betram, N.G. Bérubé, X. Hang-Swanson, Q. Ran, J.K. Leung, S. Bryce, K. Spurgers, R.J. Bick, A. Baldini, and Y. Ning Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes Mol. Cell. Biol. 19 1999 1479 1485
6. J. Bond, M. Haughton, J. Blaydes, V. Gire, D. Wynford-Thomas, and F. Wyllie Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence Oncogene 13 1996 2097 2104
7. L. Davis, and G. Kuttan Effect of Withania somnifera on CTL activity J. Exp. Clinical Cancer Res. 21 2002 115 118
8. P.U. Devi Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization Ind. J. Exp. Biol. 34 1996 927 932
9. J.N. Dhuley Adaptogenic and cardioprotective action of ashwagandha in rats and frogs J. Ethnopharmacol. 70 2000 57 63
10. S. Douc-Rasy, and J. Benard A new view on p53 protein cytoplasmic sequestration Bull. Cancer 90 2003 380 382
11. B.M. Fontoura, C.A. Atienza, E.A. Sorokina, T. Morimoto, and R.B. Carroll Cytoplasmic p53 polypeptide is associated with ribosomes Mol. Cell. Biol. 17 1997 3146 3154
12. M. Furmanowa, D. Gajdzis-Kuls, J. Ruszkowska, Z. Czarnocki, G. Obidoska, A. Sadowska, R. Rani, and S.N. Upadhyay In vitro propagation of Withania somnifera and isolation of withanolides with immunosuppressive activity Planta Medica 67 2001 146 149
13. T.K. Garg, and J.Y. Chang Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: Prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2 BMC Ophthalmol. 3 2003 5
14. S.K. Gupta, A. Dua, and B.P. Vohra Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications Drug Metabol. Drug Interact. 19 2003 211 222
15. T. Iuvone, G. Esposito, F. Capasso, and A.A. Izzo Induction of nitric oxide synthase expression by Withania somnifera in macrophages Life Sci. 72 2003 1617 1625
16. B.P.S. Kang, S. Frencher, V. Reddy, A. Kessler, A. Malhotra, and L.G. Meggs High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism Am. J. Physiol. Renal Physiol. 284 2003 F455 466
17. S.C. Kaul, K. Taira, O.M. Pereira-Smith, and R. Wadhwa Mortalin: present and prospective Exp. Gerontol. 37 2002 1157 1164
18. T. Kuboyama, C. Tohda, J. Zhao, N. Nakamura, M. Hattori, and K. Komatsu Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha Neuroreport 13 2002 1715 1720
19. K.S. Kulju, and J.M. Lehman Increased p53 protein associated with aging in human diploid fibroblasts Exp. Cell Res. 217 1995 336 345
20. D. Lavie, I. Kirson, and E. Glotter Constituents of Withania somnifera Dun. Part X. The structure of withanolide D. Israel J.Chem. 6 1968 671 678
21. M. Li, P.M. Absher, P. Liang, J.C. Russel, and B.E. Sobel High glucose concentrations induce oxidative damage to mitochondrial DNA in explanted vascular smooth muscle cells Exp. Biol. Med. 226 2001 450 457
22. E. Michishita, K. Nakabayashi, T. Suzuki, S.C. Kaul, H. Ogino, M. Fujii, Y. Mitsui, and D. Ayusawa 5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species J. Biochem. 126 1999 1052 1059
23. L.C. Mishra, B.B. Singh, and S. Dagenais Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review Alt. Med. Rev. 5 2000 334 346
24. U.M. Moll, A.G. Ostermeyer, R. Haladay, B. Winkfield, M. Frazier, and G. Zambetti Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage Mol. Cell. Biol. 16 1996 1126 1137
25. S. Panda, and A. Kar Evidence for free radical scavenging activity of Ashwagandha root powder in mice Ind. J. Physiol. Pharmacol. 41 1997 424 426
26. J. Prakash, S.K. Gupta, and A.K. Dinda Withania somnifera root extract prevents DMBA-induced squamous cell carcinoma of skin in Swiss albino mice Nutr. Cancer 42 2002 91 97
27. J.W. Russell, D. Golovoy, P.M. Vincent, J.A. Olzmann, A. Mentzer, and E.L. Feldman High glucose-induced oxidative stress and mitochondrial dysfunction in neurons The FASEB J. 16 2002 1738 1748
28. P. Scartezzini, and E. Speroni Review on some plants of Indian traditional medicine with antioxidant activity J. Ethnopharmacol. 71 2000 23 43
29. C. Tohda, T. Kuboyama, and K. Komatsu Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK-N-SH cells Neuroreport 11 2000 1981 1985
30. R. Wadhwa, S.C. Kaul, Y. Mitsui, and Y. Sugimoto Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts Exp. Cell Res. 20 1993 442 448
31. R. Wadhwa, T. Sugihara, A. Yoshida, H. Nomura, R.R. Reddel, R. Simpson, H. Maruta, and S.C. Kaul Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function Cancer Res. 60 2000 6818 6821
32. R. Wadhwa, K. Taira, and S.C. Kaul An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where Cell Stress Chaperones 7 2002 309 316
33. R. Wadhwa, K. Taira, and S.C. Kaul Mortalin: a potential candidate for biotechnology and biomedicine Histol. Histopathol. 17 2002 1173 1177
34. D. Wynford-Thomas, C.J. Jones, and F.S Wyllie The tumour suppressor gene p53 as a regulator of proliferative life-span and tumour progression Biol. Signals 5 1996 139 153
35. J. Zhao, N. Nakamura, M. Hattori, T. Kuboyama, C. Tohda, and K. Komatsu Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities Chem. Pharm. Bull. (Tokyo) 50 2002 760 765