Effects of compounds that influence IK (KCNN4) channels on afterhyperpolarizing potentials, and determination of IK channel sequence, in guinea pig enteric neurons

Journal of Neurophysiology

Volumn 97, Issue 3, 2007, Pages 2024-2031

  Nguyen, Trung V ^a   Matsuyama, Hayato ^a,b   Baell, Jonathan ^c   Hunne, Billie ^a   Fowler, Christopher J ^a   Smith, Julia E ^d   Nurgali, Kulmira ^a   Furness, John B ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b GIFU UNIVERSITY   (Japan)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DICHLORO 1 ETHYL 2 BENZIMIDAZOLINONE; [1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; CLOTRIMAZOLE; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MESSENGER RNA; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ACTION POTENTIAL; AFTERHYPERPOLARIZATION; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GUINEA PIG; INTESTINE INNERVATION; MALE; MICROELECTRODE; MYENTERIC PLEXUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; BENZIMIDAZOLES; CLOTRIMAZOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; FEMALE; GENE EXPRESSION; GUINEA PIGS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ION CHANNEL GATING; MALE; MEMBRANE POTENTIALS; MYENTERIC PLEXUS; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PYRAZOLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, PROTEIN;

EID: 33947187227     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00935.2006     Document Type: Article

References (43)

1. Arnold SJ, Facer P, Yiangou Y, Chen MX, Plumpton C, Tate SN, Bountra C, Chan CLH, Williams NS, Anand P. Decreased potassium channel IKI and its regulator neurotrophin-3 (NT-3) in inflamed human bowel. Neuroreport 14: 191-195, 2003.
2. Bertrand PP, Kunze WAA, Bornstein JC, Furness JB, Smith ML. Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa. Am J Physiol Gastrointest Liver Physiol 273: G422-G435, 1997.
3. + channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum. Naunyn-Schmiedeberg's Arch Pharmacol 369: 602-615, 2004.
4. Clerc N, Gola M, Vogalis F, Furness JB. Controlling the excitability of IPANs: a possible route to therapeutics. Curr Opin Pharm 2: 657-664, 2002.
5. Davies PJ, Thomas EA, Bornstein JC. Different types of potassium channels underlie the long afterhyperpolarization in guinea-pig sympathetic and enteric neurons. Autonom Neurosci 124: 26-30, 2006.
6. + channels from human erythrocytes. J Membr Biol 165: 133-143, 1998.
7. Furness JB. The Enteric Nervous System. Oxford, UK: Blackwell, 2006.
8. Furness JB, Jones C, Nurgali K, Clerc N. Intrinsic primary afferent neurons and nerve circuits within the intestine. Prog Neurobiol 72: 143-164, 2004.
9. Furness JB, Robbins HL, Selmer I-S, Hunne B, Chen MX, Hicks GA, Moore S, Neylon CB. Expression of intermediate conductance potassium channel immunoreactivity in neurons and epithelial cells of the rat gastrointestinal tract. Cell Tissue Res 314: 179-189, 2003.
10. Galligan JJ, North RA, Tokimasa T. Muscarinic agonists and potassium currents in guinea-pig myenteric neurons. Br J Pharmacol 96: 193-203, 1989.
11. H) in guinea-pig enteric neurons. Am J Physiol Gastrointest Liver Physiol 259: G966-G972, 1990.
12. Gershon MD. Nerves, reflexes, and the enteric nervous system. J Clin Gastroenterol 38: S184-S193, 2005.
13. Hafsi N, Hann Von Weyhern CW, Zeller F, Smith J, Chen M, Schemann M. The calcium activated K channel of intermediate conductance (IK) modulates excitability of human enteric neurons. Neurogastroenterol Motil 18: 700, 2006.
14. Hirst GDS, Holman ME, Spence I. Two types of neurons in the myenteric plexus of duodenum in the guinea pig. J Physiol 236: 303-326, 1974.
15. Hirst GDS, Johnson SM, van Helden DF. The slow calcium-dependent potassium current in a myenteric neurone of the guinea pig ileum. J Physiol 361: 315-337, 1985.
16. Kirchgessner AL, Tamir H, Gershon MD. Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. J Neurosci 12: 235-248, 1992.
17. + channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. J Biol Chem 278: 3323-3330, 2003.
18. Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski H-D, Reusch H-P, Paul M, Chandy KG, Hoyer J. Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation 108: 1119-1125, 2003.
19. Kunze WAA, Bornstein JC, Furness JB, Hendriks R, Stephenson DSH. Charybdotoxin and iberiotoxin but not apamin abolish the slow after-hyperpolarization in myenteic plexus neurons. Pfluegers Eur J Physiol 428: 300-306, 1994.
20. Kunze WAA, Clerc N, Furness JB, Gola M. The soma and neurites of primary afferent neurons in the guinea pig intestine respond differentially to deformation. J Physiol 526: 375-385, 2000.
21. Kunze WAA, Furness JB, Bertrand PP, Bornstein JC. Intracellular recording from myenteric neurons of the guinea pig ileum that respond to stretch. J Physiol 506: 827-842, 1998.
22. Mao Y, Wang B, Kunze W. Characterization of myenteric sensory neurons in the mouse small intestine. J Neurophysiol 96: 998-1010, 2006.
23. Morita K, North RA, Tokimasa T. The calcium-activated potassium conductance in guinea pig myenteric neurons. J Physiol 329: 341-354, 1982.
24. 2+-activated potassium channels expressed in Xenopus oocytes. Eur J Physiol 448: 613-620, 2004a.
25. Ca channel diversity and smooth muscle cell function. Circ Res 85: e33-e43, 1999.
26. Neylon CB, Nurgali K, Hunne B, Robbins HL, Moore S, Chen MX, Furness JB. Intermediate-conductance calcium-activated potassium channels in enteric neurones of the mouse. J Neurochem 90: 1414-1422, 2004b.
27. North RA. The calcium-dependent slow after-hyperpolarization in myenteric plexus neuron with tetrodotoxin-resistant action potentials. Br J Pharmacol 49: 709-711, 1973.
28. North RA. Electrophysiology of the enteric neurons. In: Handbook of Experimental Pharmacology: Mediators and Drugs in Gastrointestinal Motility, edited by Bertaccini G. Berlin: Springer, 1982, p. 145-179.
29. North RA, Tokimasa T. Persistent calcium-sensitive potassium current and the resting properties of guinea pig myenteric neurons. J Physiol 386: 333-353, 1987.
30. Rugiero F, Gola M, Kunze WAA, Reynaud J-C, Furness JB, Clerc N. Analysis of whole cell currents by patch clamp of guinea pig myenteric neurons in intact ganglia. J Physiol 538: 447-463, 2002.
31. Singer W. Neuronal synchrony: a versatile code for the definition of relations? Neuron 24: 49-65, 1999.
32. Singh S, Syme CA, Singh AK, Devor DC, Bridges RJ. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther 296: 600-611, 2001.
33. Somogyi P, Klausberger T. Defined types of cortical interneuron structure space and spike timing in the hippocampus. J Physiol 562: 9-26, 2005.
34. Tack JF, Wood JD. Electrical behavior of myenteric neurons in the gastric antrum of the guinea pig. J Physiol 447: 49-66, 1992.
35. Thomas EA, Bornstein JC. Inhibitory cotransmission or after-hyperpolarizing potentials can regulate firing in recurrent networks with excitatory metabotropic transmission. Neuroscience 120: 333-352, 2003.
36. Thompson-Vest N, Shimizu Y, Hunne B, Furness JB. The distribution of intermediate conductance, calcium-activated, potassium (IK) channels in epithelial cells. J Anat 208: 219-229, 2006.
37. Vergara C, Latorre R, Marrion NV, Adelman JP. Calcium-activated potassium channels. Curr Opin Neurobiol 8: 321-329, 1998.
38. Ca channels in guinea-pig myenteric neurons: slow AHP channels. J Physiol 538: 421-433, 2002a.
39. + channel underlies the slow after-hyperpolarization in enteric AH neurons. J Physiol 548: 801-814, 2003.
40. 2+ -activated cation conductance in myenteric AH-neurons. Neuroscience 115: 375-393, 2002b.
41. + channels underlying the slow afterhyperpolarization in enteric afterhyperpolarizationgenerating myenteric neurons: role of calcium and phosphorylation. Clin Exp Pharmacol Physiol 29: 935-943, 2002c.
42. Wulff H, Gutman GA, Cahalan MD, Chandy KG. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem 276: 32040-32045, 2001.
43. + channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci USA 97: 8151-8156, 2000.