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Volumn 11, Issue 3, 2000, Pages 267-275

Lecithin-cholesterol acyltransferase: Role in lipoprotein metabolism, reverse cholesterol transport and atherosclerosis

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; HIGH DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

EID: 0034087304     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200006000-00007     Document Type: Review
Times cited : (87)

References (80)
  • 2
    • 0032167947 scopus 로고    scopus 로고
    • Regulation of lecithin cholesterol acyltransferase activity
    • 2 Jonas A. Regulation of lecithin cholesterol acyltransferase activity. Prog Lipid Res 1998; 37:209-234. This excellent review discusses the structure and function of human LCAT, with a special emphasis on the molecular and biochemical aspects of LCAT regulation by apoA-I.
    • (1998) Prog Lipid Res , vol.37 , pp. 209-234
    • Jonas, A.1
  • 3
    • 0344549395 scopus 로고    scopus 로고
    • Advances in understanding of the role of lecithin cholesterol acyltransferase (LCAT) in cholesterol transport
    • 3 Dobiasova M, Frohlich JJ. Advances in understanding of the role of lecithin cholesterol acyltransferase (LCAT) in cholesterol transport. Clin Chim Acta 1999; 286:257-271. This excellent review describes the advances in LCAT molecular genetics, with a special emphasis on the latest development in assessment of LCAT activity as an indication of atherogenic risk.
    • (1999) Clin Chim Acta , vol.286 , pp. 257-271
    • Dobiasova, M.1    Frohlich, J.J.2
  • 4
    • 0028988781 scopus 로고
    • Lipases and lecithin: Cholesterol acyltransferase in the control of lipoprotein metabolism
    • 4 Applebaum-Bowden D. Lipases and lecithin: cholesterol acyltransferase in the control of lipoprotein metabolism. Curr Opin Lipidol 1995; 6:130-135.
    • (1995) Curr Opin Lipidol , vol.6 , pp. 130-135
    • Applebaum-Bowden, D.1
  • 6
    • 0031887830 scopus 로고    scopus 로고
    • A proposed architecture for lecithin cholesterol acyl transferase (LCAT): Identification of the catalytic triad and molecular modeling
    • 6 Peelman F, Vinaimont N, Verhee A, Vanloo B, Verschelde JL, Labeur C, et al. A proposed architecture for lecithin cholesterol acyl transferase (LCAT): identification of the catalytic triad and molecular modeling. Protein Sci 1998; 7:587-599. On the basis of molecular modeling studies, the authors propose that LCAT belongs to the α/β hydrolase family, with a central domain consisting of seven conserved, mostly parallel β-strands surrounded by four α-helices, and separated by loops linking the β-strands.
    • (1998) Protein Sci , vol.7 , pp. 587-599
    • Peelman, F.1    Vinaimont, N.2    Verhee, A.3    Vanloo, B.4    Verschelde, J.L.5    Labeur, C.6
  • 7
    • 0034100270 scopus 로고    scopus 로고
    • Structure and function of LCAT: New insights from structural predictions and animal models
    • 7 Peelman F, Vandekerckhove J, Rosseneu M. Structure and function of LCAT: new insights from structural predictions and animal models. Curr Opin Lipidol 2000; 11:155-160. This is an excellent review that summarizes the proposed LCAT structural motifs and discusses the impacts of FLD and FED point mutations on the overall structure of the enzyme.
    • (2000) Curr Opin Lipidol , vol.11 , pp. 155-160
    • Peelman, F.1    Vandekerckhove, J.2    Rosseneu, M.3
  • 8
    • 0028144266 scopus 로고
    • Markedly accelerated catabolism of apolipoprotein A-II (ApoA-IIl) and high density lipoproteins containing ApoA-II in classic lecithin:Cholesterol acyltransferase deficiency and fish-eye disease
    • 8 Rader DJ, Ikewaki K, Duverger N, Schmidt H, Pritchard H, Frohlich J, et al. Markedly accelerated catabolism of apolipoprotein A-II (ApoA-IIl) and high density lipoproteins containing ApoA-II in classic lecithin:cholesterol acyltransferase deficiency and fish-eye disease. J Clin Invest 1994; 93:321-330.
    • (1994) J Clin Invest , vol.93 , pp. 321-330
    • Rader, D.J.1    Ikewaki, K.2    Duverger, N.3    Schmidt, H.4    Pritchard, H.5    Frohlich, J.6
  • 9
    • 0030897994 scopus 로고    scopus 로고
    • Targeted disruption of the mouse lecithin:Cholesterol acyltransferase (LCAT) gene
    • 9 Sakai N, Vaisman BL, Koch CA, Hoyt Jr RF, Meyn SM, Talley GD, et al. Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. J Biol Chem 1997; 272:7506-7510.
    • (1997) J Biol Chem , vol.272 , pp. 7506-7510
    • Sakai, N.1    Vaisman, B.L.2    Koch, C.A.3    Hoyt R.F., Jr.4    Meyn, S.M.5    Talley, G.D.6
  • 10
    • 0030991224 scopus 로고    scopus 로고
    • Disruption of the murine lecithin:Cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I
    • 10 Ng DS, Francone OL, Forte TM, Zhang J, Haghpassand M, Rubin EM. Disruption of the murine lecithin:cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I. J Biol Chem 1997; 272:15777-15781.
    • (1997) J Biol Chem , vol.272 , pp. 15777-15781
    • Ng, D.S.1    Francone, O.L.2    Forte, T.M.3    Zhang, J.4    Haghpassand, M.5    Rubin, E.M.6
  • 12
    • 0032807348 scopus 로고    scopus 로고
    • Targeted disruption of the murine lecithin:Cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration
    • 12 Forte TM, Oda MN, Knoff L, Frei B, Suh J, Harmony JAK, et al. Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. J Lipid Res 1999; 40:1276-1283. Hypoalphalipoproteinemia in LCAT knockout mice is associated with decreased paraoxonase and platelet-activating factor activities, but increased apoJ levels.
    • (1999) J Lipid Res , vol.40 , pp. 1276-1283
    • Forte, T.M.1    Oda, M.N.2    Knoff, L.3    Frei, B.4    Suh, J.5    Harmony, J.A.K.6
  • 13
    • 0032814573 scopus 로고    scopus 로고
    • Classical LCAT deficiency resulting from a novel homozygous dinucleotide deletion in exon 4 of the human lecithin:Cholesterol acyltransferase gene causing a frameshift and stop codon at residue 144
    • 13 Teh EM, Chisholm JW, Dolphin PJ, Pouliquen Y, Savoldelli M, De Gennes JL, Benlian P. Classical LCAT deficiency resulting from a novel homozygous dinucleotide deletion in exon 4 of the human lecithin:cholesterol acyltransferase gene causing a frameshift and stop codon at residue 144. Atherosclerosis 1999; 146:141-151.
    • (1999) Atherosclerosis , vol.146 , pp. 141-151
    • Teh, E.M.1    Chisholm, J.W.2    Dolphin, P.J.3    Pouliquen, Y.4    Savoldelli, M.5    De Gennes, J.L.6    Benlian, P.7
  • 14
    • 0030610131 scopus 로고    scopus 로고
    • Catalytically inactive lecithin:Cholesterol acyltransferase (LCAT) caused by a Gly 30 to Ser mutation in a family with LCAT deficiency
    • 14 Yang X-P, Inazu A, Honjo A, Koizumi I, Kajinami K, Koizumi J, et al. Catalytically inactive lecithin:cholesterol acyltransferase (LCAT) caused by a Gly 30 to Ser mutation in a family with LCAT deficiency. J Lipid Res 1997; 38:585-591.
    • (1997) J Lipid Res , vol.38 , pp. 585-591
    • Yang, X.-P.1    Inazu, A.2    Honjo, A.3    Koizumi, I.4    Kajinami, K.5    Koizumi, J.6
  • 15
    • 0027464242 scopus 로고
    • Two different allelic mutations in the lecithin:Cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (tyr83-> stop) and LCAT (tyr156-> asn)
    • 15 Klein H-G, Lohse P, Duverger N, Albers JJ, Rader DJ, Zech LA, et al. Two different allelic mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (tyr83-> stop) and LCAT (tyr156-> asn). J Lipid Res 1993; 34:49-58.
    • (1993) J Lipid Res , vol.34 , pp. 49-58
    • Klein, H.-G.1    Lohse, P.2    Duverger, N.3    Albers, J.J.4    Rader, D.J.5    Zech, L.A.6
  • 16
    • 0016000928 scopus 로고
    • The ultrastructure of plasma lipoproteins in lecithin:Cholesterol acyltransferase deficiency
    • 16 Forte T, Nichols A, Glomset J, Norum K. The ultrastructure of plasma lipoproteins in lecithin:cholesterol acyltransferase deficiency. Scand J Clin Lab Invest Suppl 1974; 137:121-132.
    • (1974) Scand J Clin Lab Invest Suppl , vol.137 , pp. 121-132
    • Forte, T.1    Nichols, A.2    Glomset, J.3    Norum, K.4
  • 17
    • 0016629485 scopus 로고
    • Quantitative studies of lipoprotein-X in familial lecithin: Cholesterol acyltransferase deficiency and during cholesterol esterification
    • 17 Ritland S, Gjone E. Quantitative studies of lipoprotein-X in familial lecithin: cholesterol acyltransferase deficiency and during cholesterol esterification. Clin Chim Acta 1975; 59:109-119.
    • (1975) Clin Chim Acta , vol.59 , pp. 109-119
    • Ritland, S.1    Gjone, E.2
  • 18
    • 0030754901 scopus 로고    scopus 로고
    • Effect of lipoprotein-X on lipid metabolism in rat kidney
    • 18 O K, Ly M, Fang DZ, Frohlich J, Choy PC. Effect of lipoprotein-X on lipid metabolism in rat kidney. Mol Cell Biochem 1997; 173:17-24.
    • (1997) Mol Cell Biochem , vol.173 , pp. 17-24
    • Ly, M.1    Fang, D.Z.2    Frohlich, J.3    Choy, P.C.4
  • 19
    • 0030771646 scopus 로고    scopus 로고
    • Uptake and metabolism of lipoprotein-X in mesangial cells
    • 19 Lynn EG, Choy PC, Magil A, O K. Uptake and metabolism of lipoprotein-X in mesangial cells. Mol Cell Biochem 1997; 175:187-194.
    • (1997) Mol Cell Biochem , vol.175 , pp. 187-194
    • Lynn, E.G.1    Choy, P.C.2    Magil, A.3
  • 20
    • 0016150663 scopus 로고
    • Possible association between an abnormal low density lipoprotein and nephropathy in lecithin: Cholesterol acyltransferase deficiency
    • 20 Gjone E, Blomhoff JP, Skarbovik AJ. Possible association between an abnormal low density lipoprotein and nephropathy in lecithin: cholesterol acyltransferase deficiency. Clin Chim Acta 1974; 54:11-18.
    • (1974) Clin Chim Acta , vol.54 , pp. 11-18
    • Gjone, E.1    Blomhoff, J.P.2    Skarbovik, A.J.3
  • 21
    • 0030049443 scopus 로고    scopus 로고
    • Lecithin:Cholesterol acyltransferase overexpression generates hyperalphalipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits
    • 21 Hoeg JM, Vaisman BL, Demosky Jr SJ, Meyn SM, Talley GD, Hoyt Jr RF, et al. Lecithin:cholesterol acyltransferase overexpression generates hyperalphalipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits. J Biol Chem 1996; 271:4396-4402.
    • (1996) J Biol Chem , vol.271 , pp. 4396-4402
    • Hoeg, J.M.1    Vaisman, B.L.2    Demosky S.J., Jr.3    Meyn, S.M.4    Talley, G.D.5    Hoyt R.F., Jr.6
  • 22
    • 0029072512 scopus 로고
    • Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice
    • 22 Vaisman BL, Klein H-G, Rouis M, Berard AM, Kindt MR, Talley GD, et al. Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice. J Biol Chem 1995; 270:12269-12275.
    • (1995) J Biol Chem , vol.270 , pp. 12269-12275
    • Vaisman, B.L.1    Klein, H.-G.2    Rouis, M.3    Berard, A.M.4    Kindt, M.R.5    Talley, G.D.6
  • 23
    • 0029120041 scopus 로고
    • Expression of human lecithin-cholesterol acyltransferase in transgenic mice: Effect of human apolipoprotein AI and human apolipoprotein AII on plasma lipoprotein cholesterol metabolism
    • 23 Francone OL, Gong EL, Ng DS, Fielding CJ, Rubin EM. Expression of human lecithin-cholesterol acyltransferase in transgenic mice: effect of human apolipoprotein AI and human apolipoprotein AII on plasma lipoprotein cholesterol metabolism. J Clin Invest 1995; 96:1440-1448.
    • (1995) J Clin Invest , vol.96 , pp. 1440-1448
    • Francone, O.L.1    Gong, E.L.2    Ng, D.S.3    Fielding, C.J.4    Rubin, E.M.5
  • 24
    • 0029070484 scopus 로고
    • Tissue-specific expression of the human gene for lecithin-cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile
    • 24 Mehlum A, Staels B, Duverger N, Tailleux A, Castro G, Fievet C, et al. Tissue-specific expression of the human gene for lecithin-cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile. Eur J Biochem 1995; 230:567-575.
    • (1995) Eur J Biochem , vol.230 , pp. 567-575
    • Mehlum, A.1    Staels, B.2    Duverger, N.3    Tailleux, A.4    Castro, G.5    Fievet, C.6
  • 25
    • 0013694423 scopus 로고    scopus 로고
    • Expression of murine LCAT in transgenic mice; evaluation of the role of LCAT cholesteryl ester-fatty acid specificity in the development of atherosclerosis
    • abstract
    • 25 Amar MJA, Vaisman BL, Koch CA, Paiz JA, Meyn SM, Fruchart-Najib J, et al. Expression of murine LCAT in transgenic mice; evaluation of the role of LCAT cholesteryl ester-fatty acid specificity in the development of atherosclerosis. Circulation 1999; 100:1-401.[abstract]
    • (1999) Circulation , vol.100 , pp. 1-401
    • Amar, M.J.A.1    Vaisman, B.L.2    Koch, C.A.3    Paiz, J.A.4    Meyn, S.M.5    Fruchart-Najib, J.6
  • 26
    • 0002876963 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of LCAT in non-human primates leads to an antiatherogenic lipoprotein profile with increased HDL and decreased LDL
    • abstract
    • 26 Amar MJA, Shamburek RD, Foger B, Hoyt Jr RF, Wood DO, Santamarina-Fojo S, Brewer Jr HB. Adenovirus-mediated expression of LCAT in non-human primates leads to an antiatherogenic lipoprotein profile with increased HDL and decreased LDL. Circulation 1998; 98:1-35. [abstract]
    • (1998) Circulation , vol.98 , pp. 1-35
    • Amar, M.J.A.1    Shamburek, R.D.2    Foger, B.3    Hoyt R.F., Jr.4    Wood, D.O.5    Santamarina-Fojo, S.6    Brewer H.B., Jr.7
  • 27
    • 0029935422 scopus 로고    scopus 로고
    • Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits: In vivo apolipoprotein A-I catabolism is delayed in a gene dose-dependent manner
    • 27 Brousseau ME, Santamarina-Fojo S, Zech LA, Berard AM, Vaisman BL, Meyn SM, et al. Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits: in vivo apolipoprotein A-I catabolism is delayed in a gene dose-dependent manner. J Clin Invest 1996; 97:1844-1851.
    • (1996) J Clin Invest , vol.97 , pp. 1844-1851
    • Brousseau, M.E.1    Santamarina-Fojo, S.2    Zech, L.A.3    Berard, A.M.4    Vaisman, B.L.5    Meyn, S.M.6
  • 28
    • 0031443590 scopus 로고    scopus 로고
    • Overexpression of human lecithin:Cholesterol acyltransferase in cholesterol-fed rabbits: LDL metabolism and HDL metabolism are affected in a gene dose-dependent manner
    • 28 Brousseau ME, Santamarina-Fojo S, Vaisman BL, Applebaum-Bowden D, Berard AM, Talley GD, et al. Overexpression of human lecithin:cholesterol acyltransferase in cholesterol-fed rabbits: LDL metabolism and HDL metabolism are affected in a gene dose-dependent manner. J Lipid Res 1997; 38:2537-2547.
    • (1997) J Lipid Res , vol.38 , pp. 2537-2547
    • Brousseau, M.E.1    Santamarina-Fojo, S.2    Vaisman, B.L.3    Applebaum-Bowden, D.4    Berard, A.M.5    Talley, G.D.6
  • 29
    • 0039552128 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein corrects dysfunctional HDL and reduces aortic atherosclerosis in lecithin:Cholesterol acyltransferase (LCAT)-transgenic mice
    • 29 Foger B, Chase M, Amar MJ, Vaisman BL, Shamburek RD, Paigen B, et al. Cholesteryl ester transfer protein corrects dysfunctional HDL and reduces aortic atherosclerosis in lecithin:cholesterol acyltransferase (LCAT)-transgenic mice. J Biol Chem 1999; 274:36912-36920. CETP reduces atherosclerosis in human LCAT transgenic mice, an animal model with enhanced atherogenic risk due to impaired reverse cholesterol transport, by reversing the dysfunctional properties of LCAT transgenic mouse HDL. This study provides novel in-vivo evidence for a role for CETP in reverse cholesterol transport.
    • (1999) J Biol Chem , vol.274 , pp. 36912-36920
    • Foger, B.1    Chase, M.2    Amar, M.J.3    Vaisman, B.L.4    Shamburek, R.D.5    Paigen, B.6
  • 30
    • 0003115584 scopus 로고    scopus 로고
    • The effect of hepatic lipase deficiency on the plasma lipids, lipoproteins and diet-induced atherosclerosis in LCAT transgenic mice
    • abstract
    • 30 Amar MJ, Vaisman BL, Foger B, Paigen B, Talley GD, Brewer Jr HB, Santamarina-Fojo S. The effect of hepatic lipase deficiency on the plasma lipids, lipoproteins and diet-induced atherosclerosis in LCAT transgenic mice. Circulation 1997; 96:1-109.[abstract]
    • (1997) Circulation , vol.96 , pp. 1-109
    • Amar, M.J.1    Vaisman, B.L.2    Foger, B.3    Paigen, B.4    Talley, G.D.5    Brewer H.B., Jr.6    Santamarina-Fojo, S.7
  • 31
    • 0344429365 scopus 로고    scopus 로고
    • High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin cholesteryl acyltransferase
    • 31 Berard AM, Remaley AT, Vaisman BL, Paigen B, Hoyt Jr RF, Meyn SM, et al. High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin cholesteryl acyltransferase. Nature Med 1997; 3:744-749.
    • (1997) Nature Med , vol.3 , pp. 744-749
    • Berard, A.M.1    Remaley, A.T.2    Vaisman, B.L.3    Paigen, B.4    Hoyt R.F., Jr.5    Meyn, S.M.6
  • 33
    • 0029845121 scopus 로고    scopus 로고
    • Potential gene therapy for lecithin-cholesterol acyltransferase (LCAT)-deficient and hypoalphalipoproteinemia patients with adenovirus-mediated transfer of human LCAT gene
    • 33 Sequret-Mace S, Latta-Mahieu M, Castro G, Luc G, Fruchart J-C, Rubin E, et al. Potential gene therapy for lecithin-cholesterol acyltransferase (LCAT)-deficient and hypoalphalipoproteinemia patients with adenovirus-mediated transfer of human LCAT gene. Circulation 1996; 94:2177-2184.
    • (1996) Circulation , vol.94 , pp. 2177-2184
    • Sequret-Mace, S.1    Latta-Mahieu, M.2    Castro, G.3    Luc, G.4    Fruchart, J.-C.5    Rubin, E.6
  • 34
    • 0002045151 scopus 로고    scopus 로고
    • Expression of human apoA-I abolishes aortic atherosclerosis in LCAT-transgenic mice
    • abstract
    • 34 Foger B, Vaisman BL, Koch CA, Allen DT, Paiz JA, Paigen B, et al. Expression of human apoA-I abolishes aortic atherosclerosis in LCAT-transgenic mice. Circulation 1998; 1-450. [abstract]
    • (1998) Circulation , pp. 1-450
    • Foger, B.1    Vaisman, B.L.2    Koch, C.A.3    Allen, D.T.4    Paiz, J.A.5    Paigen, B.6
  • 35
    • 0031848337 scopus 로고    scopus 로고
    • Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:Cholesterol acyltransferase
    • 35 Brousseau ME, Wang J, Demosky Jr SJ, Vaisman BL, Talley GD, Santamarina-Fojo S, et al. Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase. J Lipid Res 1998; 39:1558-1567.
    • (1998) J Lipid Res , vol.39 , pp. 1558-1567
    • Brousseau, M.E.1    Wang, J.2    Demosky S.J., Jr.3    Vaisman, B.L.4    Talley, G.D.5    Santamarina-Fojo, S.6
  • 36
    • 0019948591 scopus 로고
    • Population-based reference values for lecithin-cholesterol acyltransferase (LCAT)
    • 36 Albers JJ, Bergelin RO, Adolphson JL, Wahl PW. Population-based reference values for lecithin-cholesterol acyltransferase (LCAT). Atherosclerosis 1982; 43:369-379.
    • (1982) Atherosclerosis , vol.43 , pp. 369-379
    • Albers, J.J.1    Bergelin, R.O.2    Adolphson, J.L.3    Wahl, P.W.4
  • 37
    • 0019773311 scopus 로고
    • Lecithin:Cholesterol acyltransferase (LCAT) mass; its relationship to LCAT activity and cholesterol esterification rate
    • 37 Albers JJ, Chen CH, Adolphson JL. Lecithin:cholesterol acyltransferase (LCAT) mass; its relationship to LCAT activity and cholesterol esterification rate. J Lipid Res 1981; 22:1206-1213.
    • (1981) J Lipid Res , vol.22 , pp. 1206-1213
    • Albers, J.J.1    Chen, C.H.2    Adolphson, J.L.3
  • 38
    • 0028096008 scopus 로고
    • High density lipoproteins with differing apolipoproteins: Relationships to postprandial lipemia, cholesteryl ester transfer protein, and activities of lipoprotein lipase, hepatic lipase, and lecithin:Cholesterol acyltransferase
    • 38 Mowri H-O, Patsch JR, Ritsch A, Föger B, Brown S, Patsch W. High density lipoproteins with differing apolipoproteins: relationships to postprandial lipemia, cholesteryl ester transfer protein, and activities of lipoprotein lipase, hepatic lipase, and lecithin:cholesterol acyltransferase. J Lipid Res 1994; 35:291-300.
    • (1994) J Lipid Res , vol.35 , pp. 291-300
    • Mowri, H.-O.1    Patsch, J.R.2    Ritsch, A.3    Föger, B.4    Brown, S.5    Patsch, W.6
  • 39
    • 0031028793 scopus 로고    scopus 로고
    • Determinants of plasma HDL-cholesterol in hypertriglyceridemic patients: Role of cholesterol-ester transfer protein and lecithin cholesteryl acyltransferase
    • 39 Tato F, Vega GL, Grundy SM. Determinants of plasma HDL-cholesterol in hypertriglyceridemic patients: role of cholesterol-ester transfer protein and lecithin cholesteryl acyltransferase. Arterioscler Thromb Vasc Biol 1997; 17:56-63.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 56-63
    • Tato, F.1    Vega, G.L.2    Grundy, S.M.3
  • 40
    • 0025991145 scopus 로고
    • Lecithin : Cholesterol acyltransferase activity in patients with acute myocardial infarction and coronary heart disease
    • 40 Solajic-Bozicevic N, Stavljenic A, Sesto M. Lecithin : cholesterol acyltransferase activity in patients with acute myocardial infarction and coronary heart disease. Artery 1991; 18:326-340.
    • (1991) Artery , vol.18 , pp. 326-340
    • Solajic-Bozicevic, N.1    Stavljenic, A.2    Sesto, M.3
  • 41
    • 0028670429 scopus 로고
    • Lecithin-cholesterol acyltransferase activity in patients with coronary artery disease examined by coronary angiography
    • 41 Solajic-Bozicevic N, Stavljenic-Rukavina A, Sesto M. Lecithin-cholesterol acyltransferase activity in patients with coronary artery disease examined by coronary angiography. Clin Investig 1994; 72:951-956.
    • (1994) Clin Investig , vol.72 , pp. 951-956
    • Solajic-Bozicevic, N.1    Stavljenic-Rukavina, A.2    Sesto, M.3
  • 42
    • 0023832627 scopus 로고
    • Relationship of high density lipoprotein composition to plasma lecithin:Cholesterol acyltransferase concentration in men
    • 42 Miller NE, Rajput-Williams J, Nanjee MN, Samuel L, Albers JJ. Relationship of high density lipoprotein composition to plasma lecithin:cholesterol acyltransferase concentration in men. Atherosclerosis 1988; 69:123-129.
    • (1988) Atherosclerosis , vol.69 , pp. 123-129
    • Miller, N.E.1    Rajput-Williams, J.2    Nanjee, M.N.3    Samuel, L.4    Albers, J.J.5
  • 43
    • 0025375650 scopus 로고
    • Associations of lecithin: Cholesterol acyltransferase (LCAT) mass concentrations with exercise, weight loss, and plasma lipoprotein subfraction concentrations in men
    • 43 Williams PT, Albers JJ, Krauss RM, Wood PD. Associations of lecithin: cholesterol acyltransferase (LCAT) mass concentrations with exercise, weight loss, and plasma lipoprotein subfraction concentrations in men. Atherosclerosis 1990; 82:53-58.
    • (1990) Atherosclerosis , vol.82 , pp. 53-58
    • Williams, P.T.1    Albers, J.J.2    Krauss, R.M.3    Wood, P.D.4
  • 45
    • 0033973733 scopus 로고    scopus 로고
    • LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits
    • 45 Brousseau ME, Kauffman RD, Herderick EE, Demosky Jr SJ, Evans W, Marcovina S, et al. LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits. Arterioscler Thromb Vasc Biol 2000; 20:450-458. LCAT reduces the plasma levels of apoB-containing lipoproteins and development of atherosclerosis in transgenic rabbits by upregulation of the LDL receptor.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 450-458
    • Brousseau, M.E.1    Kauffman, R.D.2    Herderick, E.E.3    Demosky S.J., Jr.4    Evans, W.5    Marcovina, S.6
  • 46
    • 0024345198 scopus 로고
    • Effect of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of Cebus monkeys
    • 46 Kuo PC, Rudd MA, Nicolosi R, Loscalzo J. Effect of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of Cebus monkeys. Arteriosclerosis 1989; 9:919-927.
    • (1989) Arteriosclerosis , vol.9 , pp. 919-927
    • Kuo, P.C.1    Rudd, M.A.2    Nicolosi, R.3    Loscalzo, J.4
  • 47
    • 0033545833 scopus 로고    scopus 로고
    • A novel lecithin-cholesterol acyltransferase antioxidant activity prevents the formation of oxidized lipids during lipoprotein oxidation
    • 47 Vohl MC, Neville TA, Kumarathasan R, Braschi S, Sparks DL. A novel lecithin-cholesterol acyltransferase antioxidant activity prevents the formation of oxidized lipids during lipoprotein oxidation. Biochem 1999; 38:5976-5981. This study establishes that the antiatherogenic role of HDL in preventing the oxidation of LDL is due to LCAT on the HDL particles. Thus, LCAT functions in lipoprotein metabolism as a phospholipase, acyltransferase in cholesterol esterification, as well as antioxidant preventing the accumulation of oxidized lipids in plasma lipoproteins.
    • (1999) Biochem , vol.38 , pp. 5976-5981
    • Vohl, M.C.1    Neville, T.A.2    Kumarathasan, R.3    Braschi, S.4    Sparks, D.L.5
  • 48
    • 0032975173 scopus 로고    scopus 로고
    • Possible induction of renal dysfunction in patients with lecithin:Cholesterol acyltransferase deficiency by oxidized phosphatidylcholine in glomeruli
    • 48 Jimi S, Uesugi N, Saku K, Itabe H, Zhang B, Arakawa K, Takebayashi S. Possible induction of renal dysfunction in patients with lecithin:cholesterol acyltransferase deficiency by oxidized phosphatidylcholine in glomeruli. Arterioscler Thromb Vasc Biol 1999; 19:794-801. Identification of oxidized phospholipids as a potential cause of renal dysfunction in FLD is described.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 794-801
    • Jimi, S.1    Uesugi, N.2    Saku, K.3    Itabe, H.4    Zhang, B.5    Arakawa, K.6    Takebayashi, S.7
  • 49
    • 0014264541 scopus 로고
    • The plasma lecithin:Cholesterol acyltransferase reaction
    • 49 Glomset JA. The plasma lecithin:cholesterol acyltransferase reaction. J Lipid Res 1968; 9:155-167.
    • (1968) J Lipid Res , vol.9 , pp. 155-167
    • Glomset, J.A.1
  • 51
    • 0021008646 scopus 로고
    • Lecithin:Cholesterol acyltransferase and the regulation of endogenous cholesterol transport
    • 51 Dobiasova M. Lecithin:cholesterol acyltransferase and the regulation of endogenous cholesterol transport. Adv Lipid Res 1983; 20:107-194.
    • (1983) Adv Lipid Res , vol.20 , pp. 107-194
    • Dobiasova, M.1
  • 52
    • 0022888155 scopus 로고
    • Lecithin: Cholesterol acyltransferase and lysolecithin in coronary atherosclerosis
    • 52 Wells IC, Peitzmeier G, Vincent JK. Lecithin: cholesterol acyltransferase and lysolecithin in coronary atherosclerosis. Exp Mol Pathol 1986; 45:303-310.
    • (1986) Exp Mol Pathol , vol.45 , pp. 303-310
    • Wells, I.C.1    Peitzmeier, G.2    Vincent, J.K.3
  • 53
    • 0031935662 scopus 로고    scopus 로고
    • An overview of reverse cholesterol transport
    • 53 Tall AR. An overview of reverse cholesterol transport. Eur Heart J 1998; 19:A31-A35.
    • (1998) Eur Heart J , vol.19
    • Tall, A.R.1
  • 54
    • 0028887870 scopus 로고
    • Molecular physiology of reverse cholesterol transport
    • 54 Fielding CJ, Fielding PE. Molecular physiology of reverse cholesterol transport. J Lipid Res 1995; 36:211-228.
    • (1995) J Lipid Res , vol.36 , pp. 211-228
    • Fielding, C.J.1    Fielding, P.E.2
  • 55
    • 0032813808 scopus 로고    scopus 로고
    • Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
    • 55 Brooks-Wilson A, Marcil M, Clee SM, Zhang L-H, Roomp K, van Dam M, et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nature Genet 1999; 22:336-345. This study identifies mutations in the ABC1 gene as the underlying molecular defect in patients with Tangier disease.
    • (1999) Nature Genet , vol.22 , pp. 336-345
    • Brooks-Wilson, A.1    Marcil, M.2    Clee, S.M.3    Zhang, L.-H.4    Roomp, K.5    Van Dam, M.6
  • 56
    • 0032813660 scopus 로고    scopus 로고
    • Tangier disease is caused by mutations in the ATP binding cassette transporter 1 (ABC1) gene
    • 56 Rust S, Rosier M, Funke H, Real J, Amoura Z, Piette JC, et al. Tangier disease is caused by mutations in the ATP binding cassette transporter 1 (ABC1) gene. Nature Genet 1999; 22:352-355. This study identifies mutations in the ABC1 gene as the underlying molecular defect in patients with Tangier disease.
    • (1999) Nature Genet , vol.22 , pp. 352-355
    • Rust, S.1    Rosier, M.2    Funke, H.3    Real, J.4    Amoura, Z.5    Piette, J.C.6
  • 57
    • 0032813809 scopus 로고    scopus 로고
    • The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
    • 57 Bodzioch M, Orso E, Klucken J, Langmann T, Bottcher A, Diederich W, et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nature Genet 1999; 22:347-351. This study identifies mutations in the ABC1 gene as the underlying molecular defect in patients with Tangier disease.
    • (1999) Nature Genet , vol.22 , pp. 347-351
    • Bodzioch, M.1    Orso, E.2    Klucken, J.3    Langmann, T.4    Bottcher, A.5    Diederich, W.6
  • 58
    • 0342811295 scopus 로고    scopus 로고
    • Human ATP-binding cassette transporter 1 (ABC1): Genomic organization and identification of the genetic defect in the original Tangier disease kindred
    • 58 Remaley AT, Rust S, Rosier M, Knapper C, Naudin L, Broccardo C, et al. Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred. Proc Natl Acad Sci USA 1999; 96:12685-12690. A description is provided of the genomic organization of ABC1 and identification of the molecular defect in the ABC1 gene of patients from the original Tangier disease kindred.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12685-12690
    • Remaley, A.T.1    Rust, S.2    Rosier, M.3    Knapper, C.4    Naudin, L.5    Broccardo, C.6
  • 60
    • 0025819206 scopus 로고
    • A molecular defect causing fish eye disease: An amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of α-LCAT activity
    • 60 Funke H, von Eckardstein A, Pritchard PH, Albers JJ, Kastelein JJP, Droste C, Assmann G. A molecular defect causing fish eye disease: an amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of α-LCAT activity. Proc Natl Acad Sci USA 1991; 88:4855-4859.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4855-4859
    • Funke, H.1    Von Eckardstein, A.2    Pritchard, P.H.3    Albers, J.J.4    Kastelein, J.J.P.5    Droste, C.6    Assmann, G.7
  • 62
    • 0028854477 scopus 로고
    • Deficiency of lecithin:Cholesterol acyltransferase due to compound heterozygosity of two novel mutations (Gly33Arg and 30 bp ins) in the LCAT gene
    • 62 Wiebusch H, Cullen P, Owen JS, Collins D, Sharp PS, Funke H, Assmann G. Deficiency of lecithin:cholesterol acyltransferase due to compound heterozygosity of two novel mutations (Gly33Arg and 30 bp ins) in the LCAT gene. Hum Mol Genet 1995; 4:143-145.
    • (1995) Hum Mol Genet , vol.4 , pp. 143-145
    • Wiebusch, H.1    Cullen, P.2    Owen, J.S.3    Collins, D.4    Sharp, P.S.5    Funke, H.6    Assmann, G.7
  • 63
    • 0013694484 scopus 로고    scopus 로고
    • A novel mutation in lecithin:Cholesterol acyltransferase (LCAT) leading to fish-eye disease in South American female patient with proven coronary artery disease
    • abstract
    • 63 Molhuizen HO, Brites FD, Petersen W, Fernandez K, Wikinski RW, Ayyobi AF, Kastelein JJP. A novel mutation in lecithin:cholesterol acyltransferase (LCAT) leading to fish-eye disease in South American female patient with proven coronary artery disease. Circulation 1999; 100:1-256.[abstract]
    • (1999) Circulation , vol.100 , pp. 1-256
    • Molhuizen, H.O.1    Brites, F.D.2    Petersen, W.3    Fernandez, K.4    Wikinski, R.W.5    Ayyobi, A.F.6    Kastelein, J.J.P.7
  • 64
    • 0013670791 scopus 로고    scopus 로고
    • Lecithin-cholesterol acyltransferase deficiency: Human in vivo kinetics of LDL, apoA-I and apoA-II in partial LCAT deficiency (fish eye disease) with and without CAD
    • abstract
    • 64 Shamburek RD, Talley GD, Kindt MR, Kuivenhoven JA, Kastelein JJP, Stalenhoef AFH, Brewer Jr HB. Lecithin-cholesterol acyltransferase deficiency: human in vivo kinetics of LDL, apoA-I and apoA-II in partial LCAT deficiency (fish eye disease) with and without CAD. Circulation 1997; 96:1-723.[abstract]
    • (1997) Circulation , vol.96 , pp. 1-723
    • Shamburek, R.D.1    Talley, G.D.2    Kindt, M.R.3    Kuivenhoven, J.A.4    Kastelein, J.J.P.5    Stalenhoef, A.F.H.6    Brewer H.B., Jr.7
  • 66
    • 0029080806 scopus 로고
    • Specificity of lecithin:Cholesterol acyltransferase and atherogenic risk: Comparative studies on the plasma composition and in vitro synthesis of cholesteryl esters in 14 vertebrate species
    • 66 Liu M, Bagdade JD, Subbaiah PV. Specificity of lecithin:cholesterol acyltransferase and atherogenic risk: comparative studies on the plasma composition and in vitro synthesis of cholesteryl esters in 14 vertebrate species. J Lipid Res 1995; 36:1813-1824.
    • (1995) J Lipid Res , vol.36 , pp. 1813-1824
    • Liu, M.1    Bagdade, J.D.2    Subbaiah, P.V.3
  • 67
    • 0021923801 scopus 로고
    • Acyl chain and headgroup specificity of human plasma lecithin:Cholesterol acyltransferase. Separation of matrix and molecular specificities
    • 67 Pownall HJ, Pao Q, Massey JB. Acyl chain and headgroup specificity of human plasma lecithin:cholesterol acyltransferase. Separation of matrix and molecular specificities. J Biol Chem 1985; 260:2146-2152.
    • (1985) J Biol Chem , vol.260 , pp. 2146-2152
    • Pownall, H.J.1    Pao, Q.2    Massey, J.B.3
  • 68
    • 0023664182 scopus 로고
    • Reaction of discoidal complexes of apolipoprotein A-I and various phosphatidylcholines with lecithin cholesterol acyltransferase interfacial effects
    • 68 Jonas A, Zorich NL, Kezdy KE, Trick WE. Reaction of discoidal complexes of apolipoprotein A-I and various phosphatidylcholines with lecithin cholesterol acyltransferase interfacial effects. J Biol Chem 1987; 262:3969-3974.
    • (1987) J Biol Chem , vol.262 , pp. 3969-3974
    • Jonas, A.1    Zorich, N.L.2    Kezdy, K.E.3    Trick, W.E.4
  • 69
    • 0025878994 scopus 로고
    • Comparative specificity of plasma lecithin:Cholesterol acyltransferase from ten animal species
    • 69 Grove D, Pownall HJ. Comparative specificity of plasma lecithin:cholesterol acyltransferase from ten animal species. Lipids 1991; 26:416-420.
    • (1991) Lipids , vol.26 , pp. 416-420
    • Grove, D.1    Pownall, H.J.2
  • 70
    • 0030034577 scopus 로고    scopus 로고
    • Comparative studies on the substrate specificity of lecithin:Cholesterol acyltransferase towards the molecular species of phosphatidylcholine in the plasma of 14 vertebrates
    • 70 Subbaiah PV, Liu M. Comparative studies on the substrate specificity of lecithin:cholesterol acyltransferase towards the molecular species of phosphatidylcholine in the plasma of 14 vertebrates. J Lipid Res 1996; 37:113-122.
    • (1996) J Lipid Res , vol.37 , pp. 113-122
    • Subbaiah, P.V.1    Liu, M.2
  • 71
    • 0023845319 scopus 로고
    • An epidemiology appraisal of the associations between the fatty acids esterifying serum cholesterol and some cardiovascular risk factors in middle-aged men
    • 71 Cambien F, Warnet JM, Vernier V, Ducimetiere P, Jacqueson A, Flament C, et al. An epidemiology appraisal of the associations between the fatty acids esterifying serum cholesterol and some cardiovascular risk factors in middle-aged men. Am J Epidemiol 19B8; 127:75-86.
    • (1988) Am J Epidemiol , vol.127 , pp. 75-86
    • Cambien, F.1    Warnet, J.M.2    Vernier, V.3    Ducimetiere, P.4    Jacqueson, A.5    Flament, C.6
  • 73
    • 0013983040 scopus 로고
    • Correlation of arachidonic acid of sterol esters with restrictive and susceptibility to naturally-occurring atherosclerosis in pigeons
    • 73 Young F, Middleton CC. Correlation of arachidonic acid of sterol esters with restrictive and susceptibility to naturally-occurring atherosclerosis in pigeons. Proc Soc Exp Biol Med 1966; 123:816-819.
    • (1966) Proc Soc Exp Biol Med , vol.123 , pp. 816-819
    • Young, F.1    Middleton, C.C.2
  • 74
    • 0027571076 scopus 로고
    • Correlation of serum lipids, lipoproteins, lipid peroxide products and metals with coronary heart disease
    • 74 Wen Y, Qian XX, Jia GL, Gao SB, Jin YF, Han DY, He SF. Correlation of serum lipids, lipoproteins, lipid peroxide products and metals with coronary heart disease. Chin Med J [Engl] 1993; 106:167-170.
    • (1993) Chin Med J [Engl] , vol.106 , pp. 167-170
    • Wen, Y.1    Qian, X.X.2    Jia, G.L.3    Gao, S.B.4    Jin, Y.F.5    Han, D.Y.6    He, S.F.7
  • 75
    • 0032714652 scopus 로고    scopus 로고
    • Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:Cholesterol acyltransferase genes
    • 75 Foumier N, Atger V, Paul JL, de la Llera Moya M, Rothblat G, Moatti N. Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis 1999; 147:227-235.
    • (1999) Atherosclerosis , vol.147 , pp. 227-235
    • Foumier, N.1    Atger, V.2    Paul, J.L.3    De La Llera Moya, M.4    Rothblat, G.5    Moatti, N.6
  • 77
    • 0032817966 scopus 로고    scopus 로고
    • Metabolism of oxidized phosphatidylcholines formed in oxidized low density lipoprotein by lecithin-cholesterol acyltransferase
    • 77 Itabe H, Hosoya R, Karasawa K, Jimi S, Saku K, Takebayashi S, Imanaka T, Takano T. Metabolism of oxidized phosphatidylcholines formed in oxidized low density lipoprotein by lecithin-cholesterol acyltransferase. J Biochem (Tokyo) 1999; 126:153-161.
    • (1999) J Biochem (Tokyo) , vol.126 , pp. 153-161
    • Itabe, H.1    Hosoya, R.2    Karasawa, K.3    Jimi, S.4    Saku, K.5    Takebayashi, S.6    Imanaka, T.7    Takano, T.8
  • 78
    • 0032920929 scopus 로고    scopus 로고
    • Evidence that lipid hydroperoxides inhibit plasma lecithin:Cholesterol acyltransferase activity
    • 78 Bielicki JK, Forte TM. Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity. J Lipid Res 1999; 40:948-954. Polar lipids isolated from minimally oxidized LDL dramatically inhibit LCAT activity. Phospholipid hydroperoxides were identified as the principal oxidized lipids from lipoxygenase-treated LDL, which effectively inhibits LCAT activity. This study was the first to show that phospholipid hydroperoxides may increase the atherogenic process by decreasing LCAT activity.
    • (1999) J Lipid Res , vol.40 , pp. 948-954
    • Bielicki, J.K.1    Forte, T.M.2
  • 80
    • 0032883857 scopus 로고    scopus 로고
    • Construction and characterization of polycistronic retrovirus vectors for sustained and high-level co-expression of apolipoprotein A-I and lecithin-cholesterol acyltransferase
    • 80 Fan L, Owen JS, Dickson G. Construction and characterization of polycistronic retrovirus vectors for sustained and high-level co-expression of apolipoprotein A-I and lecithin-cholesterol acyltransferase. Atherosclerosis 1999; 147:139-145. A demonstration is provided that polycistronic retrovirus vectors containing the apoA-I and LCAT genes could be used to genetically modify myoblasts that can be transplanted back into skeletal muscle for expression. This represents a novel approach to the expression of genes to potentially decrease the development of atherosclerosis.
    • (1999) Atherosclerosis , vol.147 , pp. 139-145
    • Fan, L.1    Owen, J.S.2    Dickson, G.3


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