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Construction and characterization of polycistronic retrovirus vectors for sustained and high-level co-expression of apolipoprotein A-I and lecithin-cholesterol acyltransferase
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80 Fan L, Owen JS, Dickson G. Construction and characterization of polycistronic retrovirus vectors for sustained and high-level co-expression of apolipoprotein A-I and lecithin-cholesterol acyltransferase. Atherosclerosis 1999; 147:139-145. A demonstration is provided that polycistronic retrovirus vectors containing the apoA-I and LCAT genes could be used to genetically modify myoblasts that can be transplanted back into skeletal muscle for expression. This represents a novel approach to the expression of genes to potentially decrease the development of atherosclerosis.
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(1999)
Atherosclerosis
, vol.147
, pp. 139-145
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Fan, L.1
Owen, J.S.2
Dickson, G.3
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