Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells

Oncogene

Volumn 26, Issue 11, 2007, Pages 1533-1545

  Neesse, A ^a   Gangeswaran, R ^a   Luettges, J ^b   Feakins, R ^c   Weeks, M E ^a   Lemoine, N R ^a   Crnogorac Jurcevic, T ^a,d  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b KLINIKUM SAARBRÜCKEN   (Germany)

^c ROYAL LONDON HOSPITAL   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Motility; Pancreatic adenocarcinoma; PanIN lesions; SPAG1

Indexed keywords

ANTIGEN; SPERM ASSOCIATED ANTIGEN 1; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY REACTION; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CELL MOTILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; METASTASIS; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROGNOSIS; SPERMATOGENESIS;

ADENOCARCINOMA; AMINO ACID SEQUENCE; ANTIGENS, SURFACE; CELL LINE, TUMOR; CELL MOVEMENT; DNA PRIMERS; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GTP-BINDING PROTEINS; HUMANS; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 33947156789     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209961     Document Type: Article

References (30)

1. Coral S, Sigalotti L, Altomonte M, Engelsberg A, Colizzi F, Cattarossi I et al. (2002). 5-aza-2′-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications. Clin Cancer Res 8: 2690-2695.
2. Crnogorac-Jurcevic T, Missiaglia E, Blaveri E, Gangeswaran R, Jones M, Terris B et al. (2003). Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent. J Pathol 201: 63-74.
3. Cutillas PR, Chalkley RJ, Hansen KC, Cramer R, Norden AGW, Waterfield MD et al. (2004). The urinary proteome in Fanconi syndrome implies specificity in the reabsorption of proteins by renal proximal tubule cells. Am J Physiol 287: F353-F364.
4. Feinberg AP, Tycko B. (2004). The history of cancer epigenetics. Nat Rev Cancer 4: 143-153.
5. Furukawa T, Duguid WP, Rosenberg L, Viallet J, Galloway DA, Tsao MS. (1996). Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. Am J Pathol 148: 1763-1770.
6. Gesierich S, Paret C, Hildebrand D, Weitz J, Zgraggen K, Schmitz-Winnenthal FH et al. (2005). Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. Clin Cancer Res 11: 2840-2852.
7. Giehl K, Skripczynski B, Mansard A, Menke A, Gierschik P. (2000). Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Oncogene 19: 2930-2942.
8. Grutzmann R, Boriss H, Ammerpohl O, Luttges J, Kalthoff H, Schackert HK et al. (2005). Meta-analysis of microarray data on pancreatic cancer defines a set of commonly dysregulated genes. Oncogene 24: 5079-5088.
9. Hustinx SR, Cao D, Maitra A, Sato N, Martin ST, Sudhir D et al. (2004). Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression. Cancer Biol Ther 3: 1254-1261.
10. Jemal A, Thomas A, Murray T, Thun M. (2002). Cancer statistics, 2002. CA Cancer J Clin 52: 23-47.
11. Kalejs M, Erenpreisa J. (2005). Cancer/testis antigens and gametogenesis: a review and 'brain-storming' session. Cancer Cell Int 5: 4.
12. Kubuschok B, Xie X, Jesnowski R, Preuss KD, Romeike BF, Neumann F et al. (2004). Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis. Int J Cancer 109: 568-575.
13. Lin W, Zhou X, Zhang M, Li Y, Miao S, Wang L et al. (2001). Expression and function of the HSD-3.8 gene encoding a testis-specific protein. Mol Hum Reprod 7: 811-818.
14. Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson JK, Giordano TJ et al. (2003). Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res 63: 2649-2657.
15. Michl P, Ramjaun AR, Pardo OE, Warne PH, Wagner M, Poulsom R et al. (2005). CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7: 521-532.
16. Missiaglia E, Blaveri E, Terris B, Wang YH, Costello E, Neoptolemos JP et al. (2004). Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. Int J Cancer 112: 100-112.
17. Missiaglia E, Donadelli M, Palmieri M, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR. (2005). Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2′-deoxycytidine treatment is associated with activation of the interferon signalling pathway. Oncogene 24: 199-211.
18. Old LJ. (2001). Cancer/testis (CT) antigens - a new link between gametogenesis and cancer. Cancer Immun 1: 1.
19. Sawai H, Okada Y, Funahashi H, Matsuo Y, Takahashi H, Takeyama H et al. (2005). Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Mol Cancer 4: 37.
20. Scanlan MJ, Simpson AJ, Old LJ. (2004). The cancer/testis genes: review, standardization, and commentary. Cancer Immun 4: 1.
21. Shevchenko A, Wilm M, Vorm O, Mann M. (1996). Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 68: 850-858.
22. Sigalotti L, Coral S, Altomonte M, Natali L, Gaudino G, Cacciotti P et al. (2002). Cancer testis antigens expression in mesothelioma: role of DNA methylation and bioimmunotherapeuticimplic ations. Br J Cancer 86: 979-982.
23. Simpson AJ, Caballero OL, Jungbluth A, Chen YT, Old LJ. (2005). Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer 5: 615-625.
24. Small JV, Geiger B, Kaverina I, Bershadsky A. (2002). How do microtubules guide migrating cells? Nat Rev Mol Cell Biol 3: 957-964.
25. Takimoto M, Wei G, Dosaka-Akita H, Mao P, Kondo S, Sakuragi N et al. (2002). Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers. Br J Cancer 86: 1757-1762.
26. Taniuchi K, Nakagawa H, Hosokawa M, Nakamura T, Eguchi H, Ohigashi H et al. (2005). Overexpressed Pcadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Cancer Res 65: 3092-3099.
27. Tureci O, Sahin U, Zwick C, Koslowski M, Seitz G, Pfreundschuh M. (1998). Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens. Proc Natl Acad Sci USA 95: 5211-5216.
28. Vasiliev JM. (2004). Cytoskeletal mechanisms responsible for invasive migration of neoplasticc ells. Int J Dev Biol 48: 425-439.
29. Zhang M, Zhou X, Cao D, Miao S, Wang L. (1999). Tissue specificity and expression of a human sperm protein's gene BSD-2.4. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 21: 166-169.
30. Zhang ML, Wang LF, Miao SY, Koide SS. (1992). Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility. Chin Med J (Engl) 105: 998-1003.