Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 12, 2002, Pages 1591-1594

  Porter, John R ^a   Archibald, Sarah C ^a   Brown, Julien A ^a   Childs, Kirstie ^a   Critchley, David ^a   Head, John C ^a   Hutchinson, Brian ^a   Parton, Ted A H ^a   Robinson, Martyn K ^a   Shock, Anthony ^a   Warrellow, Graham J ^a   Zomaya, Alex ^a  

^a UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; N (TRIAZIN 1,3,5 YL) PHENYLALANINE; N-(TRIAZIN-1,3,5-YL) PHENYLALANINE; PHENYLALANINE; TRIAZINE DERIVATIVE; VERY LATE ACTIVATION ANTIGEN 4; BETA1 INTEGRIN; INTEGRIN; PHENYLALANINE DERIVATIVE; TRIAZINE;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; EVALUATION; STRUCTURE ACTIVITY RELATION; ANIMAL EXPERIMENT; CONTROLLED STUDY; DRUG CLEARANCE; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; RAT;

INTEGRIN ALPHA4BETA1; PHENYLALANINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 0037124184     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00237-8     Document Type: Article

References (9)