Genome-wide linkage analysis of 160 North American families with celiac disease

Genes and Immunity

Volumn 8, Issue 2, 2007, Pages 108-114

  Garner, C P ^a   Ding, Y C ^a   Steele, L ^a   Book, L ^b   Leiferman, K ^b   Zone, J J ^b   Neuhausen, S L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; CELIAC DISEASE; CHILD; CHROMOSOME 10Q; CHROMOSOME 1Q; CHROMOSOME 3Q; CHROMOSOME 6P; CHROMOSOME 7Q; CHROMOSOME 9Q; CONTROLLED STUDY; DNA DETERMINATION; GENE LOCATION; GENE LOCUS; GENETIC PREDISPOSITION; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MICROSATELLITE MARKER; NONPARAMETRIC TEST; NORTH AMERICA; PARAMETRIC TEST; PRIORITY JOURNAL;

CELIAC DISEASE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; HUMANS; LOD SCORE; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROSATELLITE REPEATS; NORTH AMERICA;

HORDEUM; SECALE CEREALE; TRITICUM AESTIVUM;

EID: 33847783924     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6364361     Document Type: Article

References (45)

1. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: A large multicenter study. Arch Intern Med 2003; 163: 286-292.
2. Trier JS. Celiac sprue. N Engl J Med 1991; 325: 1709-1719.
3. Book L, Zone JJ, Neuhausen SL. Prevalence of celiac disease among relatives of sib pairs with celiac disease in US families. Am J Gastroenterol 2003; 98: 377-381.
4. Houlston RS, Ford D. Genetics of coeliac disease. Q J Med 1996; 89: 737-743.
5. Korponay-Szabo I, Kovacs J, Lorincz M, Torok E, Goracz G. Families with multiple cases of gluten-sensitive enteropathy. Z Gastroenterol 1998; 36: 553-558.
6. Tighe MR, Ciclitira PJ. The implications of recent advances in coeliac disease. Acta Paediatr 1993; 82: 805-810.
7. Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993; 105: 910-922.
8. Balas A, Vicario JL, Zambrano A, Acuna D, Garcia-Novo D. Absolute linkage of celiac disease and dermatitis herpetiformis to HLA-DQ. Tissue Antigens 1997; 50: 52-56.
9. Spurkland A, Ingvarsson G, Falk ES, Knutsen I, Sollid LM, Thorsby E. Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501, beta 1*02) or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers. Tissue Antigens 1997; 49: 29-34.
10. Bevan S, Popat S, Braegger CP, Busch A, O'Donoghue D, Falth-Magnusson K et al. Contribution of the MHC region to the familial risk of coeliac disease. J Med Genet 1999; 36: 687-690.
11. Petronzelli F, Bonamico M, Ferrante P, Grillo R, Mora B, Mariani P et al. Genetic contribution of the HLA region to the familial clustering of coeliac disease. Ann Hum Genet 1997; 61 (Part 4): 307-317.
12. Risch N. Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet 1987; 40: 1-14.
13. Lewis C, Book L, Black J, Sawitzke A, Cannon-Albright L, Zone J et al. Celiac disease and human leukocyte antigen genotype: Accuracy of diagnosis in self-diagnosed individuals, dosage effect, and sibling risk. J Pediatr Gastroenterol Nutr 2000; 31: 22-27.
14. Liu J, Juo SH, Holopainen P, Terwilliger J, Tong X, Grunn A et al. Genomewide linkage analysis of celiac disease in Finnish families. Am J Hum Genet 2002; 70: 51-59.
15. Neuhausen SL, Feolo M, Camp NJ, Farnham J, Book L, Zone JJ. Genome-wide linkage analysis for celiac disease in North American families. Am J Med Genet 2002; 111: 1-9.
16. King AL, Fraser JS, Moodie SJ, Curtis D, Dearlove AM, Ellis HJ et al. Coeliac disease: Follow-up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11. Ann Hum Genet 2001; 65: 377-386.
17. King AL, Yiannakou JY, Brett PM, Curtis D, Morris MA, Dearlove AM et al. A genome-wide family-based linkage study of coeliac disease. Ann Hum Genet 2000; 64: 479-490.
18. Greco L, Corazza G, Babron MC, Clot F, Fulchignoni-Lataud MC, Percopo S et al. Genome search in celiac disease. Am J Hum Genet 1998; 62: 669-675.
19. Zhong F, McCombs CC, Olson JM, Elston RC, Stevens FM, McCarthy CF et al. An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland. Nat Genet 1996; 14: 329-333.
20. Popat S, Bevan S, Braegger CP, Busch A, O'Donoghue D, Falth-Magnusson K et al. Genome screening of coeliac disease. J Med Genet 2002; 39: 328-331.
21. Rioux JD, Karinen H, Kocher K, McMahon SG, Karkkainen P, Janatuinen E et al. Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci. Am J Med Genet A 2004; 130: 345-350.
22. Woolley N, Holopainen P, Ollikainen V, Mustalahti K, Maki M, Kere J et al. A new locus for coeliac disease mapped to chromosome 15 in a population isolate. Hum Genet 2002; 111: 40-45.
23. Van Belzen MJ, Meijer JW, Sandkuijl LA, Bardoel AF, Mulder CJ, Pearson PL et al. A major non-HLA locus in celiac disease maps to chromosome 19. Gastroenterology 2003; 125: 1032-1041.
24. Babron MC, Nilsson S, Adamovic S, Naluai AT, Wahlstrom J, Ascher H et al. Meta and pooled analysis of European coeliac disease data. Eur J Hum Genet 2003; 11: 828-834.
25. Altmuller J, Palmer LJ, Fischer G, Scherb H, Wjst M. Genomewide scans of complex human diseases: True linkage is hard to find. Am J Hum Genet 2001; 69: 936-950.
26. Sherman SL, Iselius L, Ellis A, Woodrow JC, MacLean CJ. Combined segregation and linkage analysis of coeliac disease. Genet Epidemiol Suppl 1986; 1: 283-288.
27. Lopez-Vazquez A, Rodrigo L, Fuentes D, Riestra S, Bousono C, Garcia-Fernandez S et al. MHC class I chain related gene A (MICA) modulates the development of coeliac disease in patients with the high risk heterodimer DQA1*0501/ DQB1*0201. Gut 2002; 50: 336-340.
28. Gonzalez S, Rodrigo L, Lopez-Vazquez A, Fuentes D, Agudo-Ibanez L, Rodriguez-Rodero S et al. Association of MHC class I related gene B (MICB) to celiac disease. Am J Gastroenterol 2004; 99: 676-680.
29. McManus R, Moloney M, Borton M, Finch A, Chuan YT, Lawlor E et al. Association of celiac disease with microsatellite polymorphisms close to the tumor necrosis factor genes. Hum Immunol 1996; 45: 24-31.
30. Monsuur AJ, de Bakker PI, Alizadeh BZ, Zhernakova A, Bevova MR, Strengman E et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat Genet 2005; 37: 1341-1344.
31. Hunt KA, Monsuur AJ, McArdle WL, Kumar PJ, Travis SP, Walters JR et al. Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. Gut 2006; 55: 969-972.
32. Amundsen SS, Monsuur AJ, Wapenaar MC, Lie BA, Ek J, Gudjonsdottir AH et al. Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort. Hum Immunol 2006; 67: 341-345.
33. Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, Guandalini S et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005; 40: 1-19.
34. Kadunce DP, Meyer LJ, Zone JJ. IgA class antibodies in dermatitis herpetiformis: Reaction with tissue antigens. J Invest Dermatol 1989; 93: 253-258.
35. Peters MS, McEvoy MT. IgA antiendomysial antibodies in dermatitis herpetiformis. J Am Acad Dermatol 1989; 21: 1225-1231.
36. Troncone R, Maurano F, Rossi M, Micillo M, Greco L, Auricchio R et al. IgA antibodies to tissue transglutaminase: An effective diagnostic test for celiac disease. J Pediatr 1999; 134: 166-171.
37. Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabo IR, Sarnesto A et al. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology 1998; 115: 1322-1328.
38. Dieterich W, Laag E, Schopper H, Volta U, Ferguson A, Gillett H et al. Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 1998; 115: 1317-1321.
39. Clemente MG, Musu MP, Frau F, Lucia C, De Virgiliis S. Antitissue transglutaminase antibodies outside celiac disease. J Pediatr Gastroenterol Nutr 2002; 34: 31-34.
40. Di Tola M, Sabbatella L, Anania MC, Viscido A, Caprilli R, Pica R et al. Anti-tissue transglutaminase antibodies in inflammatory bowel disease: new evidence. Clin Chem Lab Med 2004; 42: 1092-1097.
41. Volta U, Molinaro N, De Franchis R, Forzenigo L, Landoni M, Fratangelo D et al. Correlation between IgA antiendomysial antibodies and subtotal villous atrophy in dermatitis herpetiformis. J Clin Gastroenterol 1992; 14: 298-301.
42. Rostami K, Kerckhaert J, Tiemessen R, von Blomberg BM, Meijer JW, Mulder CJ. Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac disease: Disappointing in clinical practice. Am J Gastroenterol 1999; 94: 888-894.
43. Rossi TM, Kumar V, Lerner A, Heitlinger LA, Tucker N, Fisher J. Relationship of endomysial antibodies to jejunal mucosal pathology: specificity towards both symptomatic and asymptomatic celiacs. J Pediatr Gastroenterol Nutr 1988; 7: 858-863.
44. O'Connell JR, Weeks DE. PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998; 63: 259-266.
45. Broman KW, Murray JC, Sheffield VC, White RL, Weber JL. Comprehensive human genetic maps: Individual and sex-specific variation in recombination. Am J Hum Genet 1998; 63: 861-869.