Synthesis and QSAR studies on thiazolidinones as anti-HIV agents

Combinatorial Chemistry and High Throughput Screening

Volumn 8, Issue 5, 2005, Pages 439-443

  Rawal, Ravindra K ^c   Solomon, V Raja ^c   Prabhakar, Yenamandra S ^c   Katti, S B ^a   De Clercq, E ^b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c NONE

Author keywords

4 thiazolidinones; Anti HIV agents; Dicyclohexylcarbodiimide (DCC); Metathiazanones; NNRTIs

Indexed keywords

2 (2,6 DICHLOROPHENYL) 1 OXO 3 PYRIDIN 2 YL 1LAMBDA 4 THIAZOLIDIN 4 ONE; 2 (2,6 DICHLOROPHENYL) 3 FURAN 2 YLMETHYL 5 METHYLTHIAZOLIDIN 4 ONE; 2 (2,6 DICHLOROPHENYL) 3 FURAN 2 YLMETHYLTHIAZINAN 4 ONE; 2 (2,6 DICHLOROPHENYL) 3 FURAN 2 YLMETHYLTHIAZOLIDIN 4 ONE; 2 (2,6 DICHLOROPHENYL) 3 PYRIDIN 3 YLMETHYL [1,3]THIAZINAN 4 ONE; 2 (2,6 DICHLOROPHENYL) 3 PYRIDIN 3 YLMETHYLTHIAZOLIDIN 4 ONE; 2 (2,6 DICHLOROPHENYL) 5 METHYL 3 PYRIDIN 2 YLTHIAZOLIDIN 4 ONE; 2 (2,6 DICHLOROPHENYL) 5 METHYL 3 PYRIDIN 3 YLMETHYLTHIAZOLIDIN 4 ONE; 4 THIAZOLIDINONE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-HIV AGENTS; CELL LINE; COMBINATORIAL CHEMISTRY TECHNIQUES; HIV PROTEASE INHIBITORS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, CHEMICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REVERSE TRANSCRIPTASE INHIBITORS; THIAZOLIDINEDIONES; TOXICITY TESTS; VIRUS REPLICATION;

EID: 22444437113     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/1386207054546496     Document Type: Article

References (11)

1. De Clercq, E. II Farmaco. 1999, 54, 26-45.
2. (a) Baba, M.; Tanaka, H.; De Clercq, E.; Pauwels, R.; Balzarini, J.; Schols, D.; Nakashima, H.; Perno, C.F.; Walker, R. T.; Miyasaka, T. Biochem. Biophys. Res. Commun., 1989, 165, 1375
3. (b) Chimirri, A.; Grasso, S.; Molica, C.; Monforte, A.M.; Monforte, P.; Zappala, M.; Bruno, G.; Niclo, F.; Witvrouw, M.; Jonckeere, H.; Balzarini, J.; De Clercq, E. Antiviral Chem. Chemother., 1997, 8, 360-370;
4. (c) Chimirri, A.; Grasso, S.; Monforte, A.M.; Monforte, P.; Rao, A.; Zappala, M.; Bruno, G.; Niclo, F.; Witvrouw, M.; Pannecouque, C.; De Clercq, E. Antiviral Chem. Chemother., 1998, 9, 431-438;
5. (d) Chimirri, A.; Grasso, S.; Monforte, A.M.; Monforte, P.; Rao, A.; Zappala, M.; Bruno, G.; Niclo, F.; Witvrouw, M.; Pannecouque, C.; Balzarini, J.; De Clercq, E. Antiviral Chem. Chemother., 1999, 10, 211-217.
6. (a) Barreca, M. L.; Chimirri, A.; Luca, L. D.; Monforte, A. M.; Monforte, P.; Rao, A.; Zappala, M.; Balzarini, J.; De Clercq, E.; Pannecouque, C.; Witvrouw, M. Bioorg. Med. Chem. Lett., 2001, 11, 1793-96.
7. (b) Barreca, M. L.; Balzarini, J.; Chimirri, A.; De Clercq, E.; Luca, L. D.; Holtje, M. H.; Holtje, M.; Monforte, A. M.; Monforte, P.; Pannecouque, C.; Rao, A. and Zappala, M.; J. Med. Chem., 2002, 45, 5410-5413.
8. CS Chem 3D ultra version 6.0, Cambridge Soft, 100 Cambridge Park Dr. Cambridge, MA 02140-2317, USA.
9. Srivastava, T.; Haq, W. and Katti, S. B.; Tetrahedron, 2002, 58, 7619-7624.
10. Pauwels, R.; Balzarini, J.; Baba, M.; Snoeck, R.; Schols, D.; Herdewijin, P.; Desmyter, J.; De Clercq, E. J. Virol. Meth., 1988, 20, 309.
11. Connolly, M. L. The Molecular Surface Package. J. Mol. Graphics., 1993, 11, 139-41.