Identification of a new natural camptothecin analogue in targeted screening for HIF-1α inhibitors

Planta Medica

Volumn 73, Issue 1, 2007, Pages 49-52

  Klausmeyer, Paul ^a   McCloud, Thomas C ^a   Melillo, Giovanni ^a   Scudiero, Dominic A ^a   Cardellina II, John H ^b   Shoemaker, Robert H ^b  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Camptothecin; Dereplication; HIF 1 ; Ophiorrhiza trichocarpon; Rubiaceae

Indexed keywords

CAMPTOTHECIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MEHTYLENEDIOXY CAMPTOTHECIN; OPHIORRHIZA TRICHOCARPON EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE;

ARTICLE; CELL LINE; CHROMATOGRAPHY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; MEDICINAL PLANT; NONHUMAN; OPHIORRHIZA TRICHOCARPON; SPECTROSCOPY; DRUG ANTAGONISM; DRUG EFFECT; EVALUATION; PHYTOTHERAPY; PLANT; RUBIACEAE; SENSITIVITY AND SPECIFICITY;

OPHIORRHIZA; RUBIACEAE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PHYTOTHERAPY; PLANT COMPONENTS; PLANT EXTRACTS; RUBIACEAE; SENSITIVITY AND SPECIFICITY;

EID: 33847769596     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-951767     Document Type: Article

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