Impairments in acquisition and reversals of two-choice discriminations by aged rhesus monkeys

Neurobiology of Aging

Volumn 20, Issue 6, 1999, Pages 617-627

  Voytko, Mary Lou ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Learning; Monkey; Reversals, Visual Discriminations, Spatial Discriminations

Indexed keywords

AGED; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; LEARNING; MALE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SPATIAL DISCRIMINATION; VISUAL DISCRIMINATION;

AGING; ANALYSIS OF VARIANCE; ANIMALS; DISCRIMINATION (PSYCHOLOGY); FEMALE; LEARNING; MACACA MULATTA; MALE; PATTERN RECOGNITION, VISUAL;

EID: 0033400984     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(99)00097-4     Document Type: Article

References (24)

1. Arnsten A.F., Goldman-Rakic P.S. Catecholamines and cognitive decline in aged nonhuman primates. Ann NY Acad Sci. 444:1985;218-234.
2. Bachevalier J., Landis L.S., Walker L.C., Brickson M., Mishkin M., Price D.L., Cork L.C. Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction. Neurobiol Aging. 12:(2):1991;99-111.
3. Bartus R.T., Dean R.L., Fleming D.L. Aging in the rhesus monkey effects on visual discrimination learning and reversal learning . J Gerontol. 34:(2):1979;209-219.
4. Baxter M.G., Voytko M.L. Spatial orienting of attention in adult and aged rhesus monkeys. Behav Neurosci. 110:(5):1996;898-904.
5. Botwinick J. Aging, and behavior. 1978;Springer Publishing Co, New York.
6. Ciocon J.O., Potter J.F. Age-related changes in human memory normal and abnormal . Geriatrics. 43:(10):1988;43-48.
7. Davis R.T. Old monkey behavior. Exp Gerontol. 13:(3-4):1978;237-250.
8. Hayes K.J. The backward learning curve a method for the study of learning . Psychol Rev. 60:(4):1953;269-275.
9. Jones B., Mishkin M. Limbic lesions and the problem of stimulus-reinforcement associations. Exp Neurol. 36:(2):1972;362-377.
10. Lai Z.C., Moss M.B., Killiany R.J., Rosene D.L., Herndon J.G. Executive system dysfunction in the aged monkey spatial and object reversal learning . Neurobiol Aging. 16:(6):1995;947-954.
11. La Rue A. Aging, and neuropsychological assessment. 1992;Plenum Press, New York.
12. Moss M.B., Rosene D.L., Peters A. Effects of aging on visual recognition memory in the rhesus monkey. Neurobiol Aging. 9:(6):1988;495-502.
13. Presty S.K., Bachevalier J., Walker L.C., Struble R.G., Price D.L., Mishkin M., Cork L.C. Age differences in recognition memory of the rhesus monkeys (Macaca mulatta). Neurobiol Aging. 8:(5):1987;435-440.
14. Rapp P.R. Visual discrimination and reversal learning in the aged monkey (Macaca mulatta). Behav Neurosci. 104:(6):1990;876-884.
15. Rapp P.R., Amaral D.G. Recognition memory deficits in a subpopulation of aged monkeys resemble the effects of medial temporal lobe damage. Neurobiol Aging. 12:(5):1991;481-486.
16. Sutherland N.S., Mackintosh N.J. Mechanisms of animal discrimination learning. 1971;Academic Press Inc, New York.
17. Tigges J., Gordon T.P., McClure H.M., Hall E.C., Peters A. Survival rate and life span of rhesus monkeys at the Yerkes Regional Primate Research Center. Am J Primatol. 15:(3):1988;263-273.
18. Voytko M.L. Cooling orbital frontal cortex disrupts matching-to-sample and visual discrimination learning in monkeys. Physiol Psychol. 13:(4):1985;219-229.
19. Voytko M.L. Visual learning and retention examined with reversible cold lesions of the anterior temporal lobe. Behav Brain Res. 22:(1):1986;25-39.
20. Voytko M.L. Cognitive changes during normal aging in monkeys assessed with an automated test apparatus. Neurobiol Aging. 14:(6):1993;634-644.
21. Voytko M.L., Olton D.S., Richardson R.T., Gorman L.K., Tobin J.T., Price D.L. Basal forebrain lesions in monkeys disrupt attention but not learning and memory. J Neurosci. 14:(1):1994;167-186.
22. Voytko M.L., Sukhov R.R., Walker L.C., Breckler S.J., Price D.L., Koliatsos V.E. Neuronal number and size are preserved in the nucleus basalis of aged rhesus monkeys. Dementia. 6:1995;131-141.
23. Voytko M.L. Functional and neurobiological similarities of aged monkeys and humans. Age. 20:(1):1997;29-44.
24. Zola-Morgan S., Squire L.R. Preserved learning in monkeys with medial temporal lesions sparing of motor and cognitive skills . J Neurosci. 4:(4):1984;1072-1085.