Pentoxifylline attenuation of experimental hepatopulmonary syndrome

Journal of Applied Physiology

Volumn 102, Issue 3, 2007, Pages 949-955

  Zhang, Junlan ^a   Ling, Yiqun ^a   Tang, Liping ^a   Luo, Bao ^a   Chacko, Balu K ^b   Patel, Rakesh P ^b   Fallon, Michael B ^a,c,d  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Common bile duct ligation; Endothelial cells; Endothelial nitric oxide synthase; Endothelin B receptor

Indexed keywords

CYCLIC AMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN B RECEPTOR; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PENTOXIFYLLINE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; COMMON BILE DUCT; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXPERIMENTAL MODEL; HEMODYNAMICS; HEPATOPULMONARY SYNDROME; LIVER INJURY; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHEAR STRESS;

ANIMALS; CELLS, CULTURED; COMMON BILE DUCT; CYCLIC AMP; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HEPATOPULMONARY SYNDROME; LUNG; MALE; NITRIC OXIDE SYNTHASE TYPE III; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN B; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TUMOR NECROSIS FACTOR-ALPHA; VASODILATION;

EID: 33847744271     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01048.2006     Document Type: Article

References (14)

1. Boo YC, Sorescu G, Boyd N, Shiojima I, Walsh K, Du J, Jo H. Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms. Role of protein kinase A. J Biol Chem 277: 3388-3396, 2002.
2. Chang SW, Ohara N. Pulmonary circulatory dysfunction in rats with biliary cirrhosis. An animal model of the hepatopulmonary syndrome. Am Rev Respir Dis 145: 798-805, 1992.
3. Dimmeler S, Fleming I, Fissthaler B, Hermann C, Busse R, Zeiher A. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399: 601-605, 1999.
4. Fallon MB, Abrams GA, McGrath JW, Hou Z, Luo B. Common bile duct ligation in the rat: a model of intrapulmonary vasodilatation and hepatopulmonary syndrome. Am J Physiol Gastrointest Liver Physiol 272: G779-G784, 1997.
5. Gaines DI, Fallon MB. Hepatopulmonary syndrome. Liver Int 24: 397-401, 2004.
6. Kim F, Gallis B, Corson MA. TNF-α inhibits flow and insulin signaling leading to NO production in aortic endothelial cells. Am J Physiol Cell Physiol 280: C1057-C1065, 2001.
7. Lin SL, Chen RH, Chen YM, Chiang WC, Tsai TJ, Hsieh BS. Pentoxifylline inhibits platelet-derived growth factor-stimulated cyclin D1 expression in mesangial cells by blocking Akt membrane translocation. Mol Pharmacol 64: 811-822, 2003.
8. Ling Y, Zhang J, Luo B, Song D, Liu L, Tang L, Stockard C, Grizzle W, Ku D, Fallon MB. The role of endothelin-1 and the endothelin B receptor in the pathogenesis of experimental hepatopulmonary syndrome. Hepatology 39: 1593-1602, 2004.
9. Luo B, Abrams GA, Fallon MB. Endothelin-1 in the rat bile duct ligation model of hepatopulmonary syndrome: correlation with pulmonary dysfunction. J Hepatol 29: 571-578, 1998.
10. Luo B, Liu L, Tang L, Zhang J, Stockard C, Grizzle W, Fallon M. Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: a potential mechanism in experimental hepatopulmonary syndrome. J Hepatol 38: 556-563, 2003.
11. Morawietz H, Talanow R, Szibor M, Rueckschloss U, Schubert A, Bartling B, Darmer D, Holtz J. Regulation of the endothelin system by shear stress in human endothelial cells. J Physiol 525: 761-770, 2000.
12. Rabiller A, Nunes H, Lebrec D, Tazi KA, Wartski M, Dulmet E, Libert JM, Mougeot C, Moreau R, Mazmanian M, Humbert M, Herve P. Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome. Am J Respir Crit Care Med 166: 514-517, 2002.
13. Rodriguez-Roisin R, Krowka MJ, Herve P, Fallon MB; ERS Task Force Pulmonary-Hepatic Vascular Disorders (PHD) Scientific Committee. Pulmonary-hepatic vascular disorders (PHD). Eur Respir J 24: 861-880, 2004.
14. Sawle P, Foresti R, Mann BE, Johnson TR, Green CJ, Motterlini R. Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br J Pharmacol 145: 800-810, 2005.