Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: A potential mechanism in experimental hepatopulmonary syndrome

Journal of Hepatology

Volumn 38, Issue 5, 2003, Pages 556-563

  Luo, Bao ^a   Liu, Lichuan ^a   Tang, Liping ^a   Zhang, Junlan ^a   Stockard, Cecil R ^b   Grizzle, William E ^b   Fallon, Michael B ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Cirrhosis; Common bile duct ligation; Endothelial nitric oxide synthase; Endothelin receptor; Endothelin 1; Hepatopulmonary syndrome; Intrapulmonary vasodilatation; Portal hypertension; Portal vein ligation; Pulmonary artery

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; COMMON BILE DUCT; CONTROLLED STUDY; DISEASE PREDISPOSITION; HEPATOPULMONARY SYNDROME; LIVER CIRRHOSIS; LUNG ARTERY; LUNG BLOOD VESSEL; MALE; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PULMONARY ARTERY; RAT; TISSUE LEVEL; VEIN LIGATION;

EID: 0037847456     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(03)00012-6     Document Type: Article

References (24)

1. Lange PA, Stoller JK. The hepatopulmonary syndrome. Ann Intern Med 1995;122:521-529.
2. Luo B, Abrams G, Fallon M. Endothelin-1 in the rat bile duct ligation model of hepatopulmonary syndrome: correlation with pulmonary dysfunction. J Hepatol 1998;29:571-578.
3. Zhang M, Luo B, Chen SJ, Abrams GA, Fallon MB. Endothelin-1 stimulation of endothelial nitric oxide synthase in the pathogenesis of hepatopulmonary syndrome. Am J Physiol 1999;277:G944-G952.
4. De BK, Sen S, Biswas PK, Sanyal R, Jumdar DM, Biswas J. Hepatopulmonary syndrome in inferior vena cava obstruction responding to cavoplasty. Gastroenterology 2000;118:192-196.
5. Leivas A, Jimenez W, Bruix J, Boix L, Bosch J, Arroyo V, et al. Gene expression of endothelin-1 and ET(A) and ET(B) receptors in human cirrhosis: relationship with hepatic hemodynamics. J Vasc Res 1998;35:186-193.
6. Chojkier M, Groszmann RJ. Measurement of portal-systemic shunting in the rat by using gamma-labeled microspheres. Am J Physiol 1981;240:G371-G375.
7. Easter DW, Wade JB, Boyer JL. Structural integrity of hepatocyte tight junctions. J Cell Biol 1983;96:745-749.
8. Fallon MB, Abrams GA, McGrath JW, Hou Z, Luo B. Common bile duct ligation in the rat: a model of intrapulmonary vasodilatation and hepatopulmonary syndrome. Am J Physiol 1997;272:G779-G784.
9. Fallon MB, Abrams GA, Luo B, Hou Z, Dai J, Ku DD. The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome. Gastroenterology 1997;113:606-614.
10. B receptors in rats. Biochem Biophys Res Commun 1994;199:1461-1465.
11. Myers RB, Oelschlager D, Manne U, Coan PN, Weiss H, Grizzle WE. Androgenic regulation of growth factor and growth factor receptor expression in the CWR22 model of prostatic adenocarcinoma. Int J Cancer 1999;82:424-429.
12. Niederberger M, Gines P, Martin PY, Tsai P, Morris K, McMurtry I, Schrier RW. Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats. Hepatology 1996;24:947-951.
13. Martin PY, Xu DL, Niederberger M, Weigert A, Tsai P, St. John J, et al. Upregulation of endothelial constitutive NOS: a major role in the increased NO production in cirrhotic rats. Am J Physiol 1996;270:F494-F499.
14. Soma S, Takahashi H, Muramatsu M, Oka M, Fukuchi Y. Localization and distribution of endothelin receptor subtypes in pulmonary vasculature of normal and hypoxia-exposed rats. Am J Respir Cell Mol Biol 1999;20:620-630.
15. Redmond EM, Cahill PA, Sitzmann JV. Flow-mediated regulation of endothelin receptors in cocultured vascular smooth muscle cells: an endothelium-dependent effect. J Vasc Res 1997;34:425-435.
16. Cahill PA, Hou MC, Hendrickson R, Wang YN, Zhang S, Redmond EM, Sitzman JV. Increased expression of endothelin receptors in the vasculature of portal hypertensive rats: role in splanchnic hemodynamics. Hepatology 1998;28:396-403.
17. Miller VM, Gutkowska J. Modulation of arterial endothelin-1 receptors following chronic increases in blood flow. J Cardiovasc Pharmacol 1992;20:S15-S18.
18. Newman P, Kakkar VV, Kanse SM. Modulation of endothelin receptor expression in human vascular smooth muscle cells by interleukin-1 beta. FEBS Lett 1995;363:161-164.
19. Li H, Elton TS, Chen YF, Oparil S. Increased endothelin receptor gene expression in hypoxic rat lung. Am J Physiol 1994;266:L553-L560.
20. Carter EP, Hartsfield CL, Miyazono M, Jakkula M, Morris Jr KG, McMurtry IF. Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome. Am J Physiol Lung Cell Mol Physiol 2002;283:L346-L353.
21. Nunes H, Lebrec D, Mazmanian M, Capron F, Heller J, Tazi KA, et al. Role of nitric oxide in hepatopulmonary syndrome in cirrhotic rats. Am J Respir Crit Care Med 2001;164:879-885.
22. Moore K, Wendon J, Frazer M, Krani J, Williams R, Badr K. Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome. N Engl J Med 1992;327:1774-1777.
23. Eakes AT, Olson MS. Regulation of endothelin synthesis in hepatic endothelial cells. Am J Physiol 1998;274:G1068-G1076.
24. Nagasue N, Dhar DK, Yamanoi A, Emi Y, Udagawa J, Yamamoto A, et al. Production and release of endothelin-1 from the gut and spleen in portal hypertension due to cirrhosis. Hepatology 2000;31:1107-1114.