Targeted cyclooxygenase gene (Ptgs) exchange reveals discriminant isoform functionality

Journal of Biological Chemistry

Volumn 282, Issue 2, 2007, Pages 1498-1506

  Yu, Ying ^a   Fan, Jinjin ^a   Hui, Yiqun ^a   Rouzer, Carol A ^b   Marnett, Lawrence J ^b   Klein Szanto, Andres J ^c   Fitzgerald, Garret A ^a   Funk, Colin D ^a,d,e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d QUEEN S UNIVERSITY   (Canada)

^e HEART AND STROKE FOUNDATION OF CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FUNCTIONAL INTERCHANGEABILITY; GENE DISRUPTION; MITOGENESIS; TISSUE EXPRESSION PATTERNS;

ENZYMES; GLYCEROL; METABOLISM; POLYSACCHARIDES; SYNTHESIS (CHEMICAL); TISSUE;

GENE EXPRESSION;

2 ARACHIDONOYLGLYCEROL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOCANNABINOID; ISOENZYME; LIPOPOLYSACCHARIDE; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; ARACHIDONIC ACID DERIVATIVE; MEMBRANE PROTEIN; PTGS1 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBSTRATE; GENE CONTROL; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE INSERTION; GENE TARGETING; KIDNEY DISEASE; LIPID METABOLISM; MACROPHAGE; MALE; METABOLITE; MOUSE; NONHUMAN; NULL ALLELE; PERITONITIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY SEQUENCE; REPRODUCTION; URINARY EXCRETION; WILD TYPE; 3' UNTRANSLATED REGION; ANIMAL; C57BL MOUSE; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; KIDNEY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; URINARY TRACT;

MAMMALIA; MUS;

3' UNTRANSLATED REGIONS; ANIMALS; ARACHIDONIC ACIDS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; ENDOCANNABINOIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCERIDES; KIDNEY; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MODELS, ANIMAL; PERITONITIS; TRANSCRIPTION, GENETIC; URINARY TRACT;

EID: 33847726307     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609930200     Document Type: Article

References (50)

1. Smith, W. L., DeWitt, D. L., and Garavito, R. M. (2000) Annu. Rev. Biochem. 69, 145-182
2. Funk, C. D. (2001) Science 294, 1871-1875
3. Smith, W. L., Garavito, R. M., and DeWitt, D. L. (1996) J. Biol. Chem. 271, 33157-33160
4. Vane, J. R., Bakhle, Y. S., and Botting, R. M. (1998) Annu. Rev. Pharmacol. Toxicol. 38, 97-120
5. Langenbach, R., Morham, S. G., Tiano, H. F., Loftin, C. D., Ghanayem, B. I., Chulada, P. C., Mahler, J. F., Lee, C. A., Goulding, E. H., Kluckman, K. D., Kim, H. S., and Smithies, O. (1995) Cell 83, 483-492
6. Gross, G. A., Imamura, T., Luedke, C., Vogt, S. K., Olson, L. M., Nelson, D. M., Sadovsky, Y., and Muglia. L. J. (1998). Proc. Natl. Acad. Sci. U. S. A. 95, 11875-11879
7. Yu, Y., Cheng, Y., Fan, J., Chen, X. S., Klein-Szanto, A., Fitzgerald, G. A., and Funk, C. D. (2005) J. Clin. Investig. 115, 986-995
8. Takeda, H., Sonoshita, M., Oshima, H., Sugihara, K., Chulada, P. C., Langenbach, R., Oshima, M., and Taketo, M. M. (2003) Cancer Res. 63, 4872-4877
9. Tiano, H. F., Loftin, C. D., Akunda, J., Lee, C. A., Spalding, J., Sessoms, A., Dunson, D. B., Rogan, E. G., Morham, S. G., Smart, R. C., and Langenbach, R. (2002) Cancer Res. 62, 3395-3401
10. Morham, S. G., Langenbach, R., Loftin, C. D., Tiano, H. F., Vouloumanos, N., Jennette, J. C., Mahler, J. F., Kluckman, K. D., Ledford, A., Lee, C. A., and Smithies, O. (1995) Cell 83, 473-482
11. Dinchuk, J. E., Car, B. D., Focht, R. J., Johnston, J. J., Jaffee, B. D., Covington, M. B., Contel, N. R., Eng, V. M., Collins, R. J., Czerniak, P. M., Gorry, S. A., and Trzaskos, J. M. (1995) Nature 378, 406-409
12. Lim, H., Paria, B. C., Das, S. K., Dinchuk, J. E., Langenbach, R., Trzaskos, J. M., and Dey, S. K. (1997) Cell 91, 197-208
13. Reese, J., Zhao, X., Ma, W. G., Brown, N., Maziasz, T. J., and Dey, S. K. (2001) Endocrinology 142, 3198-3206
14. Wang, H., Ma, W. G., Tejada, L., Zhang, H., Morrow, J. D., Das, S. K.& Dey S. K. (2004) J. Biol. Chem. 279, 10649-10658
15. Loftin, C. D., Trivedi, D. B., Tiano, H. F., Clark, J. A., Lee, C. A., Epstein, J. A., Morham, S. G., Breyer, M. D., Nguyen, M., Hawkins, B. M., Goulet, J. L., Smithies, O., Koller, B. H., and Langenbach, R. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 1059-1064
16. Kozak, K. R., Prusakiewicz, J. J., and Marnett, L. J. (2004) Curr. Pharm. Des. 10, 659-667
17. Reddy, S. T., and Herschman, H. R. (1996) J. Biol. Chem. 271, 186-191
18. Smith, W. L., and Langenbach, R. (2001) J. Clin. Investig. 107, 1491-1495
19. Yu, Y., Fan, J., Chen, X. S., Wang, D., Klein-Szanto, A. J., Campbell, R. L., FitzGerald, G. A., and Funk, C. D. (2006) Nat. Med. 12, 699-704
20. Rouzer, C. A., and Marnett, L. J. (2005) J. Biol. Chem. 280, 26690-26700
21. Cheng, Y., Wang, M., Yu, Y., Lawson, J., Funk, C. D., and FitzGerald, G. A. (2006) J. Clin. Investig. 116, 1391-1399
22. Tanabe, T., and Tohnai, N. (2002) Prostaglandins Other Lipid Mediat. 68-69, 95-114
23. Sheng, H., Shao, J., Dixon, D. A., Williams, C. S., Prescott, S. M., DuBois, R. N., and Beauchamp, R. D. (2000) J. Biol. Chem. 275, 6628-6635
24. Catella, F., and FitzGerald, G. A. (1987) Thromb. Res. 47, 647-656
25. Moncada, S., Herman, A. G., Higgs, E. A., and Vane, J. R. (1977) Thromb. Res. 11, 323-344
26. McAdam, B. F., Catella-Lawson, F., Mardini, I. A., Kapoor, S., Lawson, J. A., and FitzGerald, G. A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 272-277
27. Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., Ueno, A., Oh-ishi, S., and Narumiya, S. (1997) Nature 388, 678-682
28. Gierse, J. K., Hauser, S. D., Creely, D. P., Koboldt, C., Rangwala, S. H., Isakson, P. C., and Seibert, K. (1995) Biochem. J. 305, 479-484
29. Barnett, J., Chow, J., Ives, D., Chiou, M., Mackenzie, R., Osen, E., Nguyen, B., Tsing, S., Bach, C., Freire, J., Chan, H., Sigal, E., and Ramesha, C. (1994) Biochim. Biophys. Acta 1209, 130-139
30. Laneuville, O., Breuer, D. K., Xu, N., Huang, Z. H., Gage, D. A., Watson, J. T., Lagarde, M., DeWitt, D. L., and Smith, W. L. (1995) J. Biol. Chem. 270, 19330-19336
31. Juranek, I., Suzuki, H., and Yamamoto, S. (1999) Biochim. Biophys. Acta 1436, 509-518
32. Swinney, D. C., Mak, A. Y., Barnett, J., and Ramesha, C. S. (1997) J. Biol. Chem. 272, 12393-12398
33. Chen, W., Pawelek, T. R., and Kulmacz, R. J. (1999) J. Biol. Chem. 274, 20301-20306
34. Shitashige, M., Morita, I., and Murota, S. (1998) Biochim. Biophys. Acta 1389, 57-66
35. Chulada, P. C., Loftin, C. D., Winn, V. D., Young, D. A., Tiano, H. F., Eling, T. E., and Langenbach, R. (1996) Arch. Biochem. Biophys. 330, 301-313
36. Kulmacz, R. J. (1998) FEBS Lett. 430, 154-157
37. Kawada, N., Solis, G., Ivey, N., Connors, S., Dennehy, K., Modlinger, P., Hamel, R., Kawada, J. T., Imai, E., Langenbach, R., Welch, W. J., and Wilcox, C. S. (2005) Hypertension 45, 1131-1138
38. Grosser, T., Fries, S., and FitzGerald, G. A. (2006) J. Clin. Investig. 116, 4-15
39. Yokoyama, C., Yabuki, T., Shimonishi, M., Wada, M., Hatae, T., Ohkawara, S., Takeda, J., Kinoshita, T., Okabe, M., and Tanabe, T. (2002) Circulation 106, 2397-2403
40. Wu, K. K., and Liou, J. Y. (2005) Biochem. Biophys. Res. Commun. 338, 45-52
41. Fitzgerald, G. A. (2004) N. Engl. J. Med. 351, 1709-17011
42. Harris, R. C. (2000) J. Am. Soc. Nephrol. 11, 2387-2394
43. Huang, J. C., Goldsby, J. S., Arbab, F., Melhem, Z., Aleksic, N., and Wu, K. K. (2004) Hum. Reprod. 19, 2907-2912
44. Huang, J. C., Wun, W. S., Goldsby, J. S., Matijevic-Aleksic, N., and Wu, K. K. (2004) Hum. Reprod. 19, 2900-2906
45. Huang, J. C., Goldsby, J. S., and Wun, W. S. (2004) Hum. Reprod. 19, 1856-1860
46. Lim, H., Gupta, R. A., Ma, W. G., Paria, B. C., Moller, D. E., Morrow, J. D., DuBois, R. N., Trzaskos, J. M., and Dey, S. K. (1999) Genes Dev. 13, 1561-1574
47. Sigthorsson, G., Simpson, R. J., Walley, M., Anthony, A., Foster, R., Hotz-Behoftsitz, C., Palizban, A., Pombo, J., Watts, J., Morham, S. G., and Bjarnason, I. (2002) Gastroenterology 122, 1913-1923
48. Schmassmann, A., Peskar, B. M., Stettler, C., Netzer, P., Stroff, T., Flogerzi, B., and Halter, F. (1998) Br. J. Pharmacol. 123, 795-804
49. Mizuno, H., Sakamoto, C., Matsuda, K., Wada, K., Uchida, T., Noguchi, H., Akamatsu, T., and Kasuga, M. (1997) Gastroenterology 112, 387-397
50. Reuter, B. K., Asfaha, S., Buret, A., Sharkey, K. A., and Wallace, J. L. (1996) J. Clin. Investig. 98, 2076-2085