Low-Dose Phosphodiesterase Inhibition Improves Responsiveness to Inhaled Nitric Oxide in Isolated Lungs From Endotoxemic Rats

Journal of Surgical Research

Volumn 138, Issue 2, 2007, Pages 224-230

  Klein, Alexandra ^a   Zils, Ulrich ^b   Bopp, Christian ^a   Gries, André ^a   Martin, Eike ^a   Gust, René ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

acute lung injury; endotoxin; isolated perfused lung; nitric oxide; pulmonary hypertension; sildenafil; zaprinast

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ESCHERICHIA COLI ENDOTOXIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PHOSPHODIESTERASE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; THROMBOXANE DERIVATIVE; ZAPRINAST;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTOXEMIA; ENZYME INHIBITION; ESCHERICHIA COLI; LOW DRUG DOSE; LUNG ARTERY PRESSURE; LUNG CIRCULATION; LUNG PARENCHYMA; LUNG PERFUSION; LUNG VENTILATION; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; VASODILATATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ADMINISTRATION, INHALATION; ANIMALS; BRONCHODILATOR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENDOTOXEMIA; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PULMONARY CIRCULATION; PULMONARY WEDGE PRESSURE; PURINES; PURINONES; RATS; RESPIRATORY DISTRESS SYNDROME, ADULT; SULFONES; VASODILATION;

EID: 33847668908     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2005.12.010     Document Type: Article

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