Effect of pentoxifylline on lung inflammation and gas exchange in a sepsis-induced acute lung injury model

Brazilian Journal of Medical and Biological Research

Volumn 39, Issue 11, 2006, Pages 1455-1463

  Oliveira Junior, I S ^a   Brunialti, M K C ^a   Koh, I H J ^a   Junqueira, V B C ^a   Salomao R ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute lung injury; Inflammatory mediators; Neutrophils; Pentoxifylline; Sepsis

Indexed keywords

CARBON DIOXIDE; MALONALDEHYDE; OXYGEN; PENTOXIFYLLINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA;

ACIDOSIS; ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD GAS ANALYSIS; CARBON DIOXIDE TENSION; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFECT; ESCHERICHIA COLI; HYPERCAPNIA; HYPOXEMIA; LEUKOCYTE COUNT; LEUKOCYTE DIFFERENTIAL COUNT; LUNG GAS EXCHANGE; LUNG LAVAGE; LUNG WEIGHT; MACROPHAGE; MALE; NEUTROPHIL; NEUTROPHIL COUNT; NONHUMAN; OXIDATIVE STRESS; PH MEASUREMENT; PNEUMONIA; RAT; SEPSIS;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; RATTUS NORVEGICUS;

EID: 33847642832     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2006001100009     Document Type: Article

References (37)

1. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 1967; 2: 319-323.
2. Villar J, Slutsky AS. Is the outcome from acute respiratory distress syndrome improving? Curr Opin Crit Care 1996; 2: 79-87.
3. Milberg JA, Davis DR, Steinberg KP, Hudson LD. Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993. JAMA 1995; 273: 306-309.
4. Villar J, Perez-Mendez L, Kacmarek RM. Current definitions of acute lung injury and the acute respiratory distress syndrome do not reflect their true severity and outcome. Intensive Care Med 1999; 25: 930-935.
5. Villar J, Slutsky AS. Ventilatory management of sepsis-associated respiratory distress syndrome. In: Fein A, Abraham EM, Balk RA, Bernard GR, Bone RC, Dantzker DR, et al. (Editors), Sepsis and multiorgan failure. Baltimore: Williams & Wilkins; 1997. p 453-461.
6. Bone RC, Sibbald WJ, Sprung CL. The ACCP-SCCM consensus conference on sepsis and organ failure. Chest 1992; 101: 1481-1483.
7. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348: 1546-1554.
8. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303-1310.
9. Esteban A, Anzueto A, Alia I, Gordo F, Apezteguia C, Palizas F, et al. How is mechanical ventilation employed in the intensive care unit? An international utilization review. Am J Respir Crit Care Med 2000; 161: 1450-1458.
10. Dreyfus D, Soler P, Basset G, Saumon G. High inflation pressure pulmonary edema: respective effects of high airway pressure, high tidal volume and positive end-expiratory pressure. Am Rev Respir Dis 1988; 137: 1159-1164.
11. Alves-Filho JC, Tavares-Murta BM, Barja-Fidalgo C, Benjaminn CF, Basile-Filho A, Arraes SM, et al. Neutrophil function in severe sepsis. Endocr Metab Immune Disord Drug Targets 2006; 6: 151-158.
12. Rice GC, Rosen J, Weeks R, Michnick J, Bursten S, Bianco JA, et al. CT-1501R selectively inhibits induced inflammatory monokines in human whole blood ex vivo. Shock 1994; 1: 254-266.
13. Kocdor MA, Kocdor H, Gulay Z, Gokce O. The effects of pentoxifylline on bacterial translocation after intestinal obstruction. Shock 2002; 18: 148-151.
14. Colson A, Willems B, Thissen JP. Inhibition of TNF-alpha production by pentoxifylline does not prevent endotoxin-induced decrease in serum IGF-l. J Endocrinol 2003; 178: 101-109.
15. Oliveira-Junior IS, Pinheiro BV, Silva ID, Salomao R, Zollner RL, Beppu OS. Pentoxifylline decreases tumor necrosis factor and interleukin-1 during high tidal volume. Braz J Med Biol Res 2003; 36: 1349-1357.
16. Stapleton RD, Wang BM, Hudson LD, Rubenfeld GD, Caldwell ES, Steinberg KP. Causes and timing of death in patients with ARDS. Chest 2005; 128: 525-532.
17. Koo DJ, Yoo P, Cioffi WG, Bland KI, Chaudry IH, Wang P. Mechanism of the beneficial effects of pentoxifylline during sepsis: maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokines. J Surg Res 2000; 91: 70-76.
18. Ohtsuka H, Higuchi T, Matsuzawa H, Sato H, Takahashi K, Takahashi J, et al. Inhibitory effect on LPS-induced tumor necrosis factor in calves treated with chlorpromazine or pentoxifylline. J Vet Med Sci 1997; 59: 1075-1077.
19. Salkowski CA, Detore G, Franks A, Falk MC, Vogel SN. Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration. Infect Immun 1998; 66: 3569-3578.
20. Malloy JL, Veldhuizen RA, McCormack FX, Korfhagen TR, Whitsett JA, Lewis JF. Pulmonary surfactant and inflammation in septic adult mice: role of surfactant protein A. J Appl Physiol 2002; 92: 809-816.
21. Abraham E, Kaneko DJ, Shenkar R. Effects of endogenous and exogenous catecholamines on LPS-induced neutrophil trafficking and activation. Am J Physiol 1999; 276: L1-L8.
22. Fan J, Marshall JC, Jimenez M, Shek PN, Zagorski J, Rotstein OD. Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide. J Immunol 1998; 161: 440-447.
23. Altemeier WA, Matute-Bello G, Gharib SA, Glenny RW, Martin TR, Liles WC. Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation. J Immunol 2005; 175: 3369-3376.
24. Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 1997; 100: 2153-2157.
25. Grutkoski PS, D'Amico R, Ayala A, Simms HH. Tumor necrosis factor-alpha-stimulated polymorphonuclear leukocytes suppress migration and bactericidal activity of polymorphonuclear leukocytes in a paracrine manner. Crit Care Med 2002; 30: 591-597.
26. MacDonald J, Galley HF, Webster NR. Oxidative stress and gene expression in sepsis. Br J Anaesth 2003; 90: 221-232.
27. Noel P, Nelson S, Bokulic R, Bagby G, Lippton H, Lipscomb G, et al. Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality. Life Sci 1990; 47: 1023-1029.
28. Chalkiadakis GE, Kostakis A, Karayannacos PE, Chalkiadakis ME, Sgouromali S, Giamarellou H, et al. Pentoxifylline in the treatment of experimental peritonitis in rats. Arch Surg 1985; 120: 1141-1144.
29. Steeb GD, Wilson MA, Garrison RN. Pentoxifylline preserves small-intestine microvascular blood flow during bacteremia. Surgery 1992; 112: 756-763.
30. Harada H, Ishizaka A, Yonemaru M, Mallick AA, Hatherill JR, Zheng H, et al. The effects of aminophylline and pentoxifylline on multiple organ damage after Escherichia coli sepsis. Am Rev Respir Dis 1989; 140: 974-980.
31. Lilly CM, Sandhu JS, Ishizaka A, Harada H, Yonemaru M, Larrick JW, et al. Pentoxifylline prevents tumor necrosis factor-induced lung injury. Am Rev Respir Dis 1989; 139: 1361-1368.
32. Zhang H, Spapen H, Benlabed M, Nguyen DN, Buurman WA, Vincent JL. Pentoxifylline improves the tissue oxygen extraction capabilities during endotoxic shock. Shock 1994; 2: 90-97.
33. Bacher A, Mayer N, Klimscha W, Oismuller C, Steltzer H, Hammerle A. Effects of pentoxifylline on hemodynamics and oxygenation in septic and nonseptic patients. Crit Care Med 1997; 25: 795-800.
34. Schade UF. Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. Circ Shock 1990; 31: 171-181.
35. Maier RV. Pentoxifylline in sepsis. Arch Surg 1998; 133: 466.
36. Voisin L, Breuille D, Ruot B, Ralliere C, Rambourdin F, Dalle M, et al. Cytokine modulation by PX differently affects specific acute phase proteins during sepsis in rats. Am J Physiol 1998; 275: R1412-R1419.
37. Krakauer T. Pentoxifylline inhibits ICAM-1 expression and chemokine production induced by proinflammatory cytokines in human pulmonary epithelial cells. Immunopharmacology 2000; 46: 253-261.