Cytosine arabinoside-metabolizing enzyme genes are underexpressed in children with MLL gene-rearranged acute lymphoblastic leukemia

Brazilian Journal of Medical and Biological Research

Volumn 39, Issue 11, 2006, Pages 1417-1423

  Mata, J F ^a   Scrideli, C A ^a   Queiroz, R P ^a   Mori, B O ^a   Emerenciano, M ^b   Pombo de Oliveira, M S ^b   Tone, L G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

Acute lymphoblastic leukemia; Cytosine arabinoside; Gene expression; Infant; Mixed lineage leukemia gene rearrangement

Indexed keywords

CYTARABINE; DEOXYCYTIDINE KINASE; DRUG METABOLIZING ENZYME; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; MESSENGER RNA; MIXED LINEAGE LEUKEMIA PROTEIN; MONOCLONAL ANTIBODY;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ANTIBODY DETECTION; ARTICLE; BRAZIL; CHILD; CHILDHOOD DISEASE; CHROMOSOME ANALYSIS; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG METABOLISM; FEMALE; FISHER EXACT TEST; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION PROFILING; GENE REARRANGEMENT; GERM LINE; HUMAN; IMMUNOPHENOTYPING; INFANT; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RANK SUM TEST; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ARA;

EID: 33847610100     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2006001100005     Document Type: Article

References (22)

1. Biondi A, Cimino G, Pieters R, Pui CH. Biological and therapeutic aspects of infant leukemia. Blood 2000; 96: 24-33.
2. Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD, et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002; 30: 41-47.
3. Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002; 1: 133-143.
4. Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, et al. Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region. Lancet 2002; 359: 1909-1915.
5. Pieters R, den Boer ML, Durian M, Janka G, Schmiegelow K, Kaspers GJ, et al. Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia - implications for treatment of infants. Leukemia 1998; 12: 1344-1348.
6. Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 2001; 15: 875-890.
7. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations. Br J Haematol 1981; 47: 553-561.
8. Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A, et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia 1995; 9: 1783-1786.
9. Macrini CM, Pombo-de-Oliveira MS, Ford AM, Alves G. MLL AT-hook sequence is strongly conserved in infant acute leukemia with or without MLL gene rearrangement. Leukemia 2003; 17: 1432-1433.
10. van Dongen JJ, MacIntyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia 1999; 13: 1901-1928.
11. Scrideli CA, Kashima S, Cipolloti R, Defavery R, Bernardes JE, Tone LG. Minimal residual disease in Brazilian children with acute lymphoid leukemia: comparison of three detection methods by PCR. Leuk Res 2002; 26: 431-438.
12. Scrideli CA, Queiroz RG, Bernardes JE, Valera ET, Tone L.G. PCR detection of clonal IgH and TCR gene rearrangements at the end of induction as a non-remission criterion in children with ALL: comparison with standard morphologic analysis and risk group classification. Med Pediatr Oncol 2003; 41: 10-16.
13. Gibson UE, Heid CA, Williams PM. A novel method for real time quantitative RT-PCR. Genome Res 1996; 6: 995-1001.
14. Beillard E, Pallisgaard N, van der Velden V, Bi W, Dee R, van der Schoot E, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using real-time quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program. Leukemia 2003; 17: 2474-2486.
15. Scrideli CA, Cazzaniga G, Fazio G, Pirola L, Callegaro A, Bassan R, et al. Gene expression profile unravels significant differences between childhood and adult Ph+ acute lymphoblastic leukemia. Leukemia 2003; 17: 2234-2237.
16. Rubnitz JE, Pui CH. Recent advances in the treatment and understanding of childhood acute lymphoblastic leukaemia. Cancer Treat Rev 2003; 29: 31-44.
17. Friedmann AM, Weinstein HJ. The role of prognostic features in the treatment of childhood acute lymphoblastic leukemia. Oncologist 2000; 5: 321-328.
18. Kaspers GJ, Pieters R, Van Zantwijk CH, van Wering ER, Veerman AJ. Clinical and cell biological features related to cellular drug resistance of childhood acute lymphoblastic leukemia cells. Leuk Lymphoma 1995; 19: 407-416.
19. Andersson A, Olofsson T, Lindgren D, Nilsson B, Ritz C, Eden P, et al. Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations. Proc Natl Acad Sci U S A 2005; 102: 19069-19074.
20. Stam RW, den Boer ML, Meijerink JP, Ebus ME, Peters GJ, Noordhuis P, et al. Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood 2003; 101: 1270-1276.
21. Lion T. Current recommendations for positive controls in RT-PCR assays. Leukemia 2001; 15: 1033-1037.
22. Mansson E, Liliemark E, Soderhall S, Gustafsson G, Eriksson S, Albertioni F. Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5′-nucleotidase mRNA measurement in cell lines and in patients with leukemia. Leukemia 2002; 16: 386-392.