5HTTLPR Polymorphism and Enlargement of the Pulvinar: Unlocking the Backdoor to the Limbic System

Biological Psychiatry

Volumn 61, Issue 6, 2007, Pages 813-818

  Young, Keith A ^a,b   Holcomb, Leigh A ^a,b   Bonkale, Willy L ^a,b   Hicks, Paul B ^a,b   Yazdani, Umar ^c   German, Dwight C ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Depression; human; postmortem; pulvinar; serotonin; thalamus

Indexed keywords

SEROTONIN TRANSPORTER;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; BIPOLAR DISORDER; CADAVER; CLINICAL ARTICLE; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEMISPHERE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIMBIC SYSTEM; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PULVINAR; SCHIZOPHRENIA; STEREOLOGY; THALAMUS;

ALLELES; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CELL COUNT; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; LIMBIC SYSTEM; MALE; MATCHED-PAIR ANALYSIS; NEURONS; ORGAN SIZE; PULVINAR; REFERENCE VALUES; SCHIZOPHRENIA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; VARIATION (GENETICS);

EID: 33847279785     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.08.047     Document Type: Article

References (50)

1. Alexander G.E., DeLong M.R., and Strick P.E. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9 (1986) 357-381
2. Arbelle S., Benjamin J., Golin M., Kremer I., Belmaker R.H., and Ebstein R.P. Relation of shyness in grade school children to the genotype for the long form of the serotonin transporter promoter region polymorphism. Am J Psychiatry 160 (2005) 671-676
3. Bennett-Clarke C.A., Leslie M.J., Lane R.D., and Rhoades R.W. Effect of serotonin depletion on vibrissa related patterns of thalamic afferents in the rat's somatosensory cortex. J Neurosci 12 (1994) 7594-7607
4. Bradley S.L., Dodelzon K., Sandhu H.K., and Philibert R.A. Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription. Am J Med Genet B Neuropsychiatr Genet 136 (2005) 58-61
5. Cases O., Vitalis T., Seif I., De Maeyer E., Sotelo C., and Gaspar P. Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: Role of a serotonin excess during the critical period. Neuron 16 (1996) 297-307
6. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
7. Champoux M., Bennett A., Shannon C., Higley J.D., Lesch K.P., and Suomi S.J. Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Mol Psychiatry 10 (2002) 1058-1063
8. Cho H.J., Meira-Lima I., Cordeiro Q., Michelon L., Sham P., Vallada H., and Collier D.A. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: A systematic review and meta-analysis. Mol Psychiatry 8 (2005) 771-781
9. Curran S., Purcell S., Craig I., Asherson P., and Sham P. The serotonin transporter gene as a QTL for ADHD. Am J Med Genet B Neuropsychiatr Genet 134 (2005) 42-47
10. de Gelder B., Morris J.S., and Dolan R.J. Unconscious fear influences emotional awareness of faces and voices. Proc Natl Acad Sci U S A 102 (2005) 18682-18687
11. Drevets W.C. Neuroimaging abnormalities in the amygdala in mood disorders. Ann N Y Acad Sci 985 (2003) 420-444
12. Esaki T., Cook M., Shimoji K., Murphy D.L., Sokoloff L., and Holmes A. Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Proc Natl Acad Sci U S A 102 (2005) 5582-5587
13. Frankle W.G., Huang Y., and Hwang D.R. Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. J Nucl Med 45 (2004) 682-694
14. Gerra G., Garofano L., Castaldini L., Rovetto F., Zaimovic A., Moi G., et al. Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents. J Neural Transm 112 (2005) 1397-1410
15. Gonda X., Juhasz G., Laszik A., Rihmer Z., and Bagdy G. Subthreshold depression is linked to the functional polymorphism of the 5HT transporter gene. J Affect Disord 87 (2005) 291-297
16. Hariri A.R., Drabant E.M., Munoz K.E., Kolachana B.S., Mattay V.S., Egan M.F., and Weinberger D.R. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 62 (2005) 146-152
17. Heils A., Mossner R., and Lesch K.P. The human serotonin transporter gene polymorphism-basic research and clinical implications. J Neural Transm 104 (1997) 1005-1014
18. Heinz A., Braus D.F., Smolka M.N., Wrase J., Puls I., Hermann D., et al. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 8 (2005) 20-21
19. Hirai T., and Jones E.G. A new parcellation of the human thalamus on the basis of histochemical staining. Brain Res Brain Res Rev 14 (1989) 1-34
20. Hoefgen B., Schulze T.G., Ohlraun S., von Widdern O., Höfels S., Gross M., et al. The power of sample size and homogenous sampling: Association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Biol Psychiatry 57 (2005) 247-251
21. Hubel D.H., and Wiesel T.N. Brain and Visual Perception: The Story of a 25-Year Collaboration (2004), Oxford University Press, Oxford, United Kingdom
22. Jones E.G. The Thalamus (1985), Plenum Press, New York
23. Jones E.G., and Burton H. A projection from the medial pulvinar to the amygdala in primates. Brain Res 104 (1976) 142-147
24. Kendler K.S., Kuhn J.W., and Prescott C.A. Childhood sexual abuse, stressful life events and risk for major depression in women. Psychol Med 34 (2004) 1475-1482
25. Kendler K.S., Kuhn J.W., Vittum J., Prescott C.A., and Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication. Arch Gen Psychiatry 62 (2005) 529-535
26. Lavoie B., and Parent A. Serotoninergic innervation of the thalamus in the primate: An immunohistochemical study. J Comp Neurol 312 (1991) 1-18
27. Lee H.J., Lee M.S., Kang R.H., Kim H., Kim S.D., Kee B.S., et al. Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress Anxiety 21 (2005) 135-139
28. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
29. Liddell B.J., Brown K.J., Kemp A.H., Barton M.J., Das P., Peduto A., et al. A direct brainstem-amygdala-cortical "alarm" system for subliminal signals of fear. Neuroimage 24 (2005) 235-243
30. Lin P.Y., and Tsai G. Association between serotonin transporter gene promoter polymorphism and suicide: Results of a meta-analysis. Biol Psychiatry 55 (2004) 1023-1030
31. Lira A., Zhou M., Castanon N., Ansorge M.S., Gordon J.A., Francis J.H., et al. Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol Psychiatry 54 (2003) 960-971
32. Mann J.J., Waternaux C., Haas G.L., and Malone K.M. Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry 156 (1999) 181-189
33. Maxwell J.S., Shackman A.J., and Davidson R.J. Unattended facial expressions asymmetrically bias the concurrent processing of non-emotional information. J Cogn Neurosci 17 (2005) 1386-1395
34. Monckton J.E., and McCormick D.A. Neuromodulatory role of serotonin in the ferret thalamus. J Neurophysiol 87 (2002) 2124-2136
35. Morris J.S., DeGelder B., Weiskrantz L., and Dolan R.J. Differential extrageniculostriate and amygdala responses to presentation of emotional faces in a cortically blind field. Brain 124 (2001) 1241-1252
36. Neumeister A., Nugent A.C., Waldeck T., Geraci M., Schwarz M., Bonne O., et al. Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls. Arch Gen Psychiatry 61 (2004) 765-773
37. Ohman A. The role of the amygdala in human fear: Automatic detection of threat. Psychoneuroendocrinology 30 (2005) 953-958
38. Oke A.F., Carver L.A., Gouvion C.M., and Adams R.N. Three-dimensional mapping of norepinephrine and serotonin in human thalamus. Brain Res 763 (1997) 69-78
39. Persico A.M., Baldi A., Dell'Acqua M.L., Moessner R., Murphy D.L., Lesch K.P., and Keller F. Reduced programmed cell death in brains of serotonin transporter knockout mice. Neuroreport 14 (2003) 341-344
40. Persico A.M., Mengual E., Moessner R., Hall F.S., Revay R.S., Sora I., et al. Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci 21 (2001) 6862-6873
41. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nat Neurosci 8 (2005) 828-834
42. Romanski L.M., Giguere M., Bates J.F., and Goldman-Rakic P.S. Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey. J Comp Neurol 379 (1997) 313-332
43. Sodhi M.S., and Sanders-Bush E. Serotonin and brain development. Int Rev Neurobiol 59 (2004) 111-174
44. Stepniewska I., Ql H.X., and Kaas J.H. Projections of the superior colliculus to subdivisions of the inferior pulvinar in New World and Old World monkeys. Vis Neurosci 17 (2000) 529-549
45. Torrey E.F., Webster M., Knable M., Johnston N., and Yolken R.H. The Stanley Foundation Brain Collection and Neuropathology Consortium. Schizophr Res 44 (2000) 151-155
46. Vuilleumier P., Armony J.L., Driver J., and Dolan R.J. Distinct spatial frequency sensitivities for processing faces and emotional expressions. Nat Neurosci 6 (2003) 624-631
47. Ward R., Danziger S., and Bamford S. Response to visual threat following damage to the pulvinar. Curr Biol 15 (2005) 571-573
48. Yirmiya N., Pilowsky T., Nemanov L., Arbelle S., Feinsilver T., Fried I., and Ebstein R.P. Evidence for an association with the serotonin transporter promoter region polymorphism and autism. Am J Med Genet 105 (2001) 381-386
49. You J.S., Hu S.Y., Chen B., and Zhang H.G. Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder. Psychiatr Genet 15 (2005) 7-11
50. Young K.A., Holcomb L.A., Yazdani U., Hicks P.B., and German D.C. Elevated neuron number in the limbic thalamus in major depression. Am J Psychiatry 161 (2004) 1270-1277