IL-10 gene knockout attenuates allergen-induced airway hyperresponsiveness in C57BL/6 mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 280, Issue 2 24-2, 2001, Pages

  Justice, J Paul ^a   Shibata, Y ^a   Sur, S ^b   Mustafa, J ^a   Fan, M ^a   Van Scott, M R ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Asthma; Bronchial hyperresponsiveness; Eosinophilia; Interleukin 10

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; RAGWEED ANTIGEN;

AIRWAY CONSTRICTION; AIRWAY RESISTANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BODY PLETHYSMOGRAPHY; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CYTOKINE RELEASE; EOSINOPHILIA; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; KNOCKOUT MOUSE; LUNG LAVAGE; LYMPHOCYTE ACTIVATION; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RESPIRATORY TRACT INFLAMMATION; SCID MOUSE; SENSITIZATION; SPLEEN CELL;

EID: 0035012780     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.280.2.l363     Document Type: Article

References (27)

1. Borish L, Aarons A, Rumbyrt J, Cvietusa P, Negri J, and Wenzel S. Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol 97: 1288-1296, 1996.
2. Florentino DF, Bond MW, and Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 170: 2081-2095, 1989.
3. Flores VP, Reiser H, and Stadecker MJ. Regulation of T helper cell responses in experimental murine schistosomiasis by IL-IO. Effect on expression of B7 and B7-2 costimulatory molecules by macrophages. J Immunol 153: 5190-5199, 1994.
4. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, and Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperresponsiveness, and lung damage in a mouse asthma model. J Exp Med 183: 195-201, 1996.
5. Garlisi CG, Falcone A, Hey JA, Paster TM, Fernandez X, Rizzo CA, Minnicozzi M, Jones H, Billah MM, Egan RW, and Umland SP. Airway eosinophils, T cells, Th2-type cytokine mRNA, and hyperresponsiveness in response to aerosol challenge of allergic mice with previously established pulmonary inflammation. Am J Respir Cell Mol Biol 17: 642-651, 1997.
6. Gieni RS, Umetsu DT, and DeKruyff RH. Ly1- (CD5-) B cells produce interleukin (IL)-10. Cell Immunol 175: 164-170, 1997.
7. Grunig G, Corry DB, Leach MW, Seymour BW, Kurup VP, and Rennick DM. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med 185: 1089-1099, 1997.
8. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, and Corry DB. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282: 2261-2263, 1998.
9. Hamelmann E, Schwarz, J, Takeda K, Oshiba A, Larsen GL, Irvin GG, and Gelfand EW. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 156: 766-775, 1997.
10. Hogan SP, Koskinen A, Matthaei KI, Young IG, and Foster PS. Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperresponsiveness, and lung damage in mice. Am J Respir Crit Care Med 157: 210-218, 1998.
11. Knolle PA, Uhrig A, Hegenbarth S, Loser E, Schmitt E, Gerken G, and Lohse AW. IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules. Clin Exp Immunol 114: 427-433, 1998.
12. Lee JJ, McGarry MP, Farmer SC, Denzler KL, Larson KA, Carrigan PE, Brenneise IE, Horton MA, Haczku A, Gelfand EW, Leikauf GD, and Lee NA. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med 185: 2143-2156, 1997.
13. Lee NA and Lee JJ. Asthma: does IL-5 have a more provocative role? Am J Respir Cell Mol Biol 16: 497-500, 1997.
14. Makela MJ, Kanehiro A, Borish L, Dakhama A, Loader J, Joetham A, Xing Z, Jordana M, Larsen GL, and Gelfand EW. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc Natl Acad Sci USA 97: 6007-6012, 2000.
15. Moore KW, O'Garra A, de Waal Malefijt, R, Vieira P, and Mosmann TR. Interleukin-10. Annu Rev Immunol 11: 165-190, 1993.
16. Mottonen M, Isomaki P, Saario R, Toivanen P, Punnonen J, and Lassila O. Interleukin-10 inhibits the capacity of synovial macrophages to function as antigen-presenting cells. Br J Rheumatol 37: 1207-1214, 1998.
17. Peebles RSJ, Liu MC, Adkinson NFJ, Lichtenstein LM, and Hamilton RG. Ragweed-specific antibodies in bronchoalveolar lavage fluids and serum before and after segmental lung challenge: IgE and IgA associated with eosinophil degranulation. J Allergy Clin Immunol 101: 265-273, 1998.
18. Rivas JM and Ullrich SE. Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10. J Immunol 149: 3865-3871, 1992.
19. Schottelius AJ, Mayo MW, Sartor RB, and Baldwin ASJ. Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding. J Biol Chem 274: 31868-31874, 1999.
20. Shi HZ, Deng JM, Xu H, Nong ZX, Xiao CQ, Liu ZM, Qin SM, Jiang HX, Liu GN, and Chen YQ. Effect of inhaled interleukin-4 on airway hyperresponsiveness in asthmatics. Am J Respir Crit Care Med 157: 1818-1821, 1998.
21. Shibata Y, Foster LA, Bradfield JF, and Myrvik QN. Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse. J Immunol 164: 1314-1321, 2000.
22. Tournoy KG, Kips JC, and Pauwels RA. Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness. Clin Exp Allergy 30: 775-783, 2000.
23. Ullrich SE. Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation. Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. J Immunol 152: 3410-3416, 1994.
24. Van Scott MR, Justice JP, Bradfield J, Sigounas A, Enright E, and Sur S. IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice. Am J Physiol Lung Cell Mol Physiol 278: L667-L674, 2000.
25. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, and Donaldson DD. Interleukin-13: central mediator of allergic asthma. Science 282: 2258-2261, 1998.
26. Yoshidome H, Kato A, Edwards MJ, and Lentsch AB. Interleukin-10 inhibits pulmonary NF-κB activation and lung injury induced by hepatic ischemia-reperfusion. Am J Physiol Lung Cell Mol Physiol 277: L919-L923, 1999.
27. Zuany-Amorin C, Haile S, Leduc D, Dumarey C, Huerre M, Vargaftig BB, and Pretolani M. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J Clin Invest 95: 2644-2651, 1995.