Causes of fetal wastage

Clinical Obstetrics and Gynecology

Volumn 50, Issue 1, 2007, Pages 10-30

  Simpson, Joe Leigh ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Chromosomal abnormalities; Fetal wastage; Genetic; Thrombophilias

Indexed keywords

ALCOHOL; CAFFEINE; CYTOKINE; DOXYCYCLINE; ENVIRONMENTAL CHEMICAL; GENE PRODUCT; RHESUS ANTIBODY;

ALLOIMMUNITY; ANEUPLOIDY; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CIGARETTE SMOKING; COMPARATIVE GENOMIC HYBRIDIZATION; DIABETES MELLITUS; FETUS WASTAGE; FIRST TRIMESTER PREGNANCY; HEREDITY; HUMAN; INFECTION; INJURY; LEIOMYOMA; LUTEAL INSUFFICIENCY; MONOSOMY X; POLYPLOIDY; PREGNANCY COMPLICATION; PSYCHOLOGICAL ASPECT; SECOND TRIMESTER ABORTION; SECOND TRIMESTER PREGNANCY; SPONTANEOUS ABORTION; THROMBOPHILIA; THYROID DISEASE; TRISOMY; UTERUS MALFORMATION; VALIDATION PROCESS; X RAY;

ABORTION, SPONTANEOUS; CHROMOSOME ABERRATIONS; FEMALE; FETUS; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY TRIMESTER, FIRST; PREGNANCY TRIMESTER, SECOND; PROGESTERONE; RECURRENCE; RISK FACTORS; THROMBOPHILIA; THYROID DISEASES; UTERINE DISEASES; UTERUS;

EID: 33847155875     PISSN: 00099201     EISSN: None     Source Type: Journal    
DOI: 10.1097/GRF.0b013e31802f11f6     Document Type: Article

References (145)

1. Simpson JL, Jauniaux E. Fetal wastage. In: Gabbe SG, Niebyl JR, Simpson JL, eds. Obstetrics: Normal and Problem Pregnancies. New York: Churchill Livingstone; 2007; Chapter 24. In press.
2. Simpson JL. Genetics of spontaneous abortions. In: Carp H, ed. Recurrent Pregnancy Loss. Abingdon Oxon, UK: Taylor and Francis Medical Books; 2006. In press.
3. Boué J, Boué A, Lazar P. Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions. Teratology. 1975;12:11-26.
4. Hassold TJ. A cytogenetic study of repeated spontaneous abortions. Am J Hum Genet. 1980;32:723-730.
5. Simpson JL, Bombard AT. Chromosomal abnormalities in spontaneous abortion: frequency, pathology and genetic counseling. In: Edmonds KBMJ, ed. Spontaneous Abortion. London: Blackwell; 1987:51-76.
6. Sorokin Y, Johnson MP, Uhlmann WR, et al. Postmortem chorionic villus sampling: correlation of cytogenetic and ultrasound findings. Am J Med Genet. 1991;39:314-316.
7. Strom CM, Ginsberg N, Applebaum M, et al. Analyses of 95 first-trimester spontaneous abortions by chorionic villus sampling and karyotype. J Assist Reprod Genet. 1992;9:458-461.
8. Shimokawa O, Harada N, Miyake N, et al. Array comparative genomic hybridization analysis in first-trimester spontaneous abortions with 'normal' karyotypes. Am J Med Genet A. 2006;140:1931-1935.
9. Schaeffer AJ, Chung J, Heretis K, et al. Comparative genomic hybridizationarray analysis enhances the detection of aneuploidies and submicroscopic imbalances in spontaneous miscarriages. Am J Hum Genet. 2004;74:1168-1174.
10. Simpson JL, Mills JL, Holmes LB, et al. Low fetal loss rates after ultrasound-proved viability in early pregnancy. JAMA. 1987;258:2555-2557.
11. Kuleshov NP. Chromosome anomalies of infants dying during the perinatal period and premature newborn. Hum Genet. 1976;31:151-160.
12. Fisher JM, Harvey JF, Morton NE, et al. Trisomy 18: studies of the parent and cell division of origin and the effect of aberrant recombination on non-disjunction. Am J Hum Genet. 1995;56:669-675.
13. Bugge M, Collins A, Petersen MB, et al. Non-disjunction of chromosome 18. Hum Mol Genet. 1998;7:661-669.
14. Hassold TJ. Nondisjunction in the human male. Curr Top Dev Biol. 1998;37:383-406.
15. Hassold T, Merrill M, Adkins K, et al. Recombination and maternal age-dependent nondisjunction: molecular studies of trisomy 16. Am J Hum Genet. 1995;57:867-874.
16. Hassold T, Abruzzo M, Adkins K, et al. Human aneuploidy: incidence, origin, and etiology. Environ Mol Mutagen. 1996;28:167-175.
17. Savage AR, Petersen MB, Pettay D, et al. Elucidating the mechanisms of paternal non-disjunction of chromosome 21 in humans. Hum Mol Genet. 1998;7:1221-1227.
18. Reddy KS. Double trisomy in spontaneous abortions. Hum Genet. 1997;101:339-345.
19. Diego-Alvarez D, Ramos-Corrales C, Garcia-Hoyos M, et al. Double trisomy in spontaneous miscarriages: cytogenetic and molecular approach. Hum Reprod. 2006;21:958-966.
20. Li S, Hassed S, Mulvihill JJ, et al. Double trisomy. Am J Med Genet A. 2004;124:96-98.
21. Clouston HJ, Herbert M, Fenwick J, et al. Cytogenetic analysis of human blastocysts. Prenat Diagn. 2002;22:1143-1152.
22. Jauniaux E, Burton GJ. Pathophysiology of histological changes in early pregnancy loss. Placenta. 2005;26:114-123.
23. McFadden DE, Robinson WP. Phenotype of triploid embryos. J Med Genet. 2006;43:609-612.
24. Jacobs PA, Angell RR, Buchanan IM, et al. The origin of human triploids. Ann Hum Genet. 1978;42:49-57.
25. Beatty RA. The origin of human triploidy: an integration of qualitative and quantitative evidence. Ann Hum Genet. 1978;41:299-314.
26. Egozcue S, Blanco J, Vidal F. Diploid sperm and the origin of triploidy. Hum Reprod. 2002;17:5-7.
27. McFadden DE, Langlois S. Parental and meiotic origin of triploidy in the embryonic and fetal periods. Clin Genet. 2000;58:192-200.
28. Rosenbusch B, Schneider M. A brief look at the origin of tetraploidy. Cytogenet Genome Res. 2004;107:128-131.
29. Baumer A, Dres D, Basaran S, et al. Parental origin of the two additional haploid sets of chromosomes in an embryo with tetraploidy. Cytogenet Genome Res. 2003;101:5-7.
30. Singh RP, Carr DH. The anatomy and histology of XO human embryos and fetuses. Anat Rec. 1966;155:369-383.
31. Jirasek JE. Principles of reproductive embryology. In: Simpson JL, ed. Disorders of Sex Differentiation: Etiology and Clinical Delineation. San Diego: Academic Press; 1976:51-110.
32. Chandley AC. The origin of chromosomal aberrations in man and their potential for survival and reproduction in the adult human population. Ann Genet. 1981;24:5-11.
33. Warburton D, Kline J, Stein Z, et al. Does the karyotype of a spontaneous abortion predict the karyotype of a subsequent abortion? Evidence from 273 women with two karyotyped spontaneous abortions. Am J Hum Genet. 1987;41:465-483.
34. Hassold TJ, Matsuyama A, Newlands IM, et al. A cytogenetic study of spontaneous abortions in Hawaii. Ann Hum Genet. 1978;41:443-454.
35. Munné S, Sandalinas M, Magli C, et al. Increased rate of aneuploid embryos in young women with previous aneuploid conceptions. Prenat Diagn. 2004;24:638-643.
36. Bianco K, Caughey AB, Shaffer BL, et al. History of miscarriage and increased incidence of fetal aneuploidy in subsequent pregnancy. Obstet Gynecol. 2006;107:1098-1102.
37. Drugan A, Koppitch FC III, Williams JC III, et al. Prenatal genetic diagnosis following recurrent early pregnancy loss. Obstet Gynecol. 1990;75:381-384.
38. Rubio C, Simon C, Vidal F, et al. Chromosomal abnormalities and embryo development in recurrent miscarriage couples. Hum Reprod. 2003;18:182-188.
39. Alberman ED. The abortus as a predictor of future trisomy 21. In: de la Cruz FF, Gerald PS, eds. Trisomy 21 (Down syndrome). Baltimore: Raven Press; 1981:69.
40. Snijders RJ, Nicolaides KH. Ultrasound Markers for Fetal Chromosomal Defects. New York: The Parthenon Publishing Group, Inc; 1996.
41. Simpson JL, Elias S, Martin AO. Parental chromosomal rearrangements associated with repetitive spontaneous abortions. Fertil Steril. 1981;36:584-590.
42. De Braekeleer M, Dao TN. Cytogenetic studies in couples experiencing repeated pregnancy losses. Hum Reprod. 1990;5:519-528.
43. Simpson JL, Meyers CM, Martin AO, et al. Translocations are infrequent among couples having repeated spontaneous abortions but no other abnormal pregnancies. Fertil Steril. 1989;51:811-814.
44. Boué A, Gallano P. A collaborative study of the segregation of inherited chromosome structural rearrangements in 1356 prenatal diagnoses. Prenat Diagn. 1984;4:45-67.
45. Daniel A, Hook EB, Wulf G. Risks of unbalanced progeny at amniocentesis to carriers of chromosome rearrangements: data from European, United States and Canadian Laboratories. Am J Med Genet. 1989;33:14-53.
46. Goddijn M, Joosten JH, Knegt AC, et al. Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage. Hum Reprod. 2004;19:1013-1017.
47. Baek KH. Aberrant gene expression associated with recurrent pregnancy loss. Mol Hum Reprod. 2004;10:291-297.
48. Philipp T, Kalousek DK. Generalized abnormal embryonic development in missed abortion: embryoscopic and cytogenetic findings. Am J Med Genet. 2002;111:43-47.
49. Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Fertil Steril. 1950;1:3.
50. Scott RT, Snyder RR, Strickland DM, et al. The effect of interobserver variation in dating endometrial histology on the diagnosis of luteal phase defects. Fertil Steril. 1988;50:888-892.
51. Li TC, Dockery P, Rogers AW, et al. How precise is histologic dating of endometrium using the standard dating criteria? Fertil Steril. 1989;51:759-763.
52. Davis OK, Berkeley AS, Naus GJ, et al. The incidence of luteal phase defect in normal, fertile women, determined by serial endometrial biopsies. Fertil Steril. 1989;51:582-586.
53. Jordan J, Craig K, Clifton DK, et al. Luteal phase defect: the sensitivity and specificity of diagnostic methods in common clinical use. Fertil Steril. 1994;62:54-62.
54. Daya S, Ward S, Burrows E. Progesterone profiles in luteal phase defect cycles and outcome of progesterone treatment in patients with recurrent spontaneous abortion. Am J Obstet Gynecol. 1988;158:225-232.
55. Coutifaris C, Myers ER, Guzick DS, et al. Histological dating of timed endometrial biopsy tissue is not related to fertility status. Fertil Steril. 2004;82:1264-1272.
56. Phung TT, Byrd JR, McDonough PG. Etiologies and subsequent reproductive performance of 100 couples with recurrent abortion. Fertil Steril. 1979;32:389-395.
57. Daya S, Ward S. Diagnostic test properties of serum progesterone in the evaluation of luteal phase defects. Fertil Steril. 1988;49:168-170.
58. Karamardian LM, Grimes DA. Luteal phase deficiency: effect of treatment on pregnancy rates. Am J Obstet Gynecol. 1992;167:1391-1398.
59. Quenby SM, Farquharson RG. Predicting recurring miscarriage: what is important? Obstet Gynecol. 1993;82:132-138.
60. Sagle M, Bishop K, Ridley N, et al. Recurrent early miscarriage and polycystic ovaries. BMJ. 1988;297:1027-1028.
61. Regan L, Owen EJ, Jacobs HS. Hypersecretion of luteinising hormone, infertility, and miscarriage. Lancet. 1990;336:1141-1144.
62. Clifford K, Rai R, Watson H, et al. Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial. BMJ. 1996;312:1508-1511.
63. Carp HJ, Hass Y, DolickyM, et al. The effect of serum follicular phase luteinizing hormone concentrations in habitual abortion: correlation with results of paternal leukocyte immunization. Hum Reprod. 1995;10:1702-1705.
64. Bussen S, Sutterlin M, Steck T. Endocrine abnormalities during the follicular phase in women with recurrent spontaneous abortion. Hum Reprod. 1999;14:18-20.
65. Tulppala M, Stenman UH, Cacciatore B, et al. Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: prospective study in 50 women. Br J Obstet Gynaecol. 1993;100:348-352.
66. Montoro M, Collea JV, Frasier SD, et al. Successful outcome of pregnancy in women with hypothyroidism. Ann Intern Med. 1981;94:31-34.
67. Bussen S, Steck T. Thyroid autoantibodies in euthyroid non-pregnant women with recurrent spontaneous abortions. Hum Reprod. 1995;10:2938-2940.
68. Stagnaro-Green A, Roman SH, Cobin RH, et al. Detection of at-risk pregnancy by means of highly sensitive assays for thyroid autoantibodies. JAMA. 1990;264:1422-1425.
69. Glinoer D, Soto MF, Bourdoux P, et al. Pregnancy in patients with mild thyroid abnormalities: maternal and neonatal repercussions. J Clin Endocrinol Metab. 1991;73:421-427.
70. Pratt DE, Kaberlein G, Dudkiewicz A, et al. The association of antithyroid antibodies in euthyroid nonpregnant women with recurrent first trimester abortions in the next pregnancy. Fertil Steril. 1993;60:1001-1005.
71. Pratt D, Novotny M, Kaberlein G, et al. Antithyroid antibodies and the association with non-organ-specific antibodies in recurrent pregnancy loss. Am J Obstet Gynecol. 1993;168:837-841.
72. Rushworth FH, Backos M, Rai R, et al. Prospective pregnancy outcome in untreated recurrent miscarriers with thyroid autoantibodies. Hum Reprod. 2000;15:1637-1639.
73. Anselmo J, Cao D, Karrison T, et al. Fetal loss associated with excess thyroid hormone exposure. JAMA. 2004;292:691-695.
74. Mills JL, Simpson JL, Driscoll SG, et al. Incidence of spontaneous abortion among normal women and insulin-dependent diabetic women whose pregnancies were identified within 21 days of conception. N Engl J Med. 1988;319:1617-1623.
75. Miodovnik M, Mimouni F, Tsang RC, et al. Glycemic control and spontaneous abortion in insulin-dependent diabetic women. Obstet Gynecol. 1986;68:366-369.
76. Ben Rafael Z, Seidman DS, Recabi K, et al. Uterine anomalies. A retrospective, matched-control study. J Reprod Med. 1991;36:723-727.
77. Salim R, Regan L, Woelfer B, et al. A comparative study of the morphology of congenital uterine anomalies in women with and without a history of recurrent first trimester miscarriage. Hum Reprod. 2003;18:162-166.
78. Michalas SP. Outcome of pregnancy in women with uterine malformation: evaluation of 62 cases. Int J Gynaecol Obstet. 1991;35:215-219.
79. Makino T, Sakai A, Sugi T, et al. Current comprehensive therapy of habitual abortion. Ann N Y Acad Sci. 1991;626:597-604.
80. Moutos DM, Damewood MD, Schlaff WD, et al. A comparison of the reproductive outcome between women with a unicornuate uterus and women with a didelphic uterus. Fertil Steril. 1992;58:88-93.
81. Golan A, Langer R, Neuman M, et al. Obstetric outcome in women with congenital uterine malformations. J Reprod Med. 1992;37:233-236.
82. Candiani GB, Fedele L, Parazzini F, et al. Reproductive prognosis after abdominal metroplasty in bicornuate or septate uterus: a life table analysis. Br J Obstet Gynaecol. 1990;97:613-617.
83. Makino T. Management of uterine congenital malformations: evaluation of outcome. In: Hedon B, Springer J, Mores P, eds. Proceedings of the 15th World Congress on Fertility and Sterility, Montpellier, France 17-22 September, 1995. New York; 1995:135-137.
84. Stein AL, March CM. Pregnancy outcome in women with mullerian duct anomalies. J Reprod Med. 1990;35:411-414.
85. Stampe SS. Estimated prevalence of mullerian anomalies. Acta Obstet Gynecol Scand. 1988;67:441-445.
86. Simon C, Martinez L, Pardo F, et al. Mullerian defects in women with normal reproductive outcome. Fertil Steril. 1991;56:1192-1193.
87. Hartmann KE, Herring AH, Savitz DA. Predictors of the presence of uterine fibroids in the first trimester of pregnancy: a prospective cohort study [Abstract 789]. J Soc Gynecol Investig. 2004;11:340A.
88. Matovina M, Husnjak K, Milutin N, et al. Possible role of bacterial and viral infections in miscarriages. Fertil Steril. 2004;81:662-669.
89. Simpson JL, Mills JL, Kim H, et al. Infectious processes: an infrequent cause of first trimester spontaneous abortions. Hum Reprod. 1996;11:668-672.
90. Stray-Pedersen B, Eng J, Reikvam TM. Uterine T-mycoplasma colonization in reproductive failure. Am J Obstet Gynecol. 1978;130:307-311.
91. Quinn PA, Petric M, Barkin M, et al. Prevalence of antibody to Chlamydia trachomatis in spontaneous abortion and infertility. Am J Obstet Gynecol. 1987;156:291-296.
92. Witkin SS, Ledger WJ. Antibodies to Chlamydia trachomatis in sera of women with recurrent spontaneous abortions. Am J Obstet Gynecol. 1992;167:135-139.
93. Rae R, Smith IW, Liston WA, et al. Chlamydial serologic studies and recurrent spontaneous abortion. Am J Obstet Gynecol. 1994;170:782-785.
94. Olliaro P, Regazzetti A, Gorini G, et al. Chlamydia trachomatis infection in "sine causa" recurrent abortion. Boll Ist Sieroter Milan. 1991;70:467-470.
95. Paukku M, Tulppala M, Puolakkainen M, et al. Lack of association between serum antibodies to Chlamydia trachomatis and a history of recurrent pregnancy loss. Fertil Steril. 1999;72:427-430.
96. van Lijnschoten G, Stals F, Evere JL, et al. The presence of cytomegalovirus antigens in karyotyped abortions. Am J Reprod Immunol. 1994;32:211-220.
97. Rock JA, Shirey RS, Braine HG, et al. Plasmapheresis for the treatment of repeated early pregnancy wastage associated with anti-P. Obstet Gynecol. 1985;66:57S-60S.
98. Strowitzki T, Wiedemann R, Heim MU, et al. Pregnancy with an extremely rare P blood group with anti-PP1Pk. Geburtshilfe Frauenheilkd. 1991;51:710-713.
99. Mills JL, Holmes LB, Aarons JH, et al. Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation. JAMA. 1993;269:593-597.
100. Raghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol Today. 1997;18:478-482.
101. Wegmann TG, Lin H, Guilbert L, et al. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today. 1993;14:353-356.
102. Cowchock S. Autoantibodies and pregnancy wastage. Am J Reprod Immunol. 1991;26:38-41.
103. Branch DW, Ward K. Antibodies and pregnancy wastage. Semin Reprod Endocrinol. 1989;1:168.
104. Scott JR, Rote NS, Branch DW. Immunologic aspects of recurrent abortion and fetal death. Obstet Gynecol. 1987;70:645-656.
105. Petri M, Golbus M, Anderson R, et al. Antinuclear antibody, lupus anticoagulant, and anticardiolipin antibody in women with idiopathic habitual abortion. A controlled, prospective study of forty-four women. Arthritis Rheum. 1987;30:601-606.
106. Carp HJ, Menashe Y, Frenkel Y, et al. Lupus anticoagulant. Significance in habitual first-trimester abortion. J Reprod Med. 1993;38:549-552.
107. Mishell DR Jr. Recurrent abortion. J Reprod Med. 1993;38:250-259.
108. Eroglu GE, Scopelitis E. Antinuclear and antiphospholipid antibodies in healthy women with recurrent spontaneous abortion. Am J Reprod Immunol. 1994;31:1-6.
109. Simpson JL, Carson SA, Chesney C, et al. Lack of association between antiphospholipid antibodies and first-trimester spontaneous abortion: prospective study of pregnancies detected within 21 days of conception. Fertil Steril. 1998;69:814-820.
110. Simpson JL, Elias S. Genetics of pregnancy loss. In: Simpson JL, Elias S, eds. Genetics in Obstetrics and Gynecology. 3rd ed. Philadelphia: W.B. Saunders; 2003:101-132.
111. Royal College of Obstetricians and Gynecologists Guidelines. The investigation and treatment of couples with recurrent miscarriages. 17, 1. 2003.
112. ACOG Practice Bulletin. Management of recurrent early pregnancy loss. 212, 2001.
113. Rai R, Regan L, Hadley E, et al. Second-trimester pregnancy loss is associated with activated C resistance. Br J Haematol. 1996;92:489-490.
114. Rai R, Chilcott IT, Backos M, et al. Prevalence of factor V Leiden genotype amongst 785 consecutive women with recurrent miscarriage. Hum Reprod 1999;14:O-130.
115. Rai R, Backos M, Chilcott IT. Prospective outcome of untreated pregnancies amongst women with the factor V Leiden genotype and recurrent miscarriages [14 Abstract]. Hum Reprod. 1999;O-037.
116. Rai R, Shlebak A, Cohen H, et al. Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Hum Reprod. 2001;16:961-965.
117. Souza SS, Ferriani RA, Pontes AG, et al. Factor V leiden and factor II G20210A mutations in patients with recurrent abortion. Hum Reprod. 1999;14:2448-2450.
118. Preston FE, Rosendaal FR, Walker ID, et al. Increased fetal loss in women with heritable thrombophilia. Lancet. 1996;348:913-916.
119. Dizon-Townson DS, Kinney S, Branch DW, et al. The factor V Leiden mutation is not a common cause of recurrent miscarriage. J Reprod Immunol. 1997;34:217-223.
120. Pauer HU, Neesen J, Hinney B. Factor V Leiden and its relevance in patients with recurrent abortions. Am J Obstet Gynecol. 1998;178:629.
121. Balasch J, Reverter JC, Fabregues F, et al. First-trimester repeated abortion is not associated with activated protein C resistance. Hum Reprod. 1997;12:1094-1097.
122. Kutteh WH, Park VM, Deitcher SR. Hypercoagulable state mutation analysis in white patients with early first-trimester recurrent pregnancy loss. Fertil Steril. 1999;71:1048-1053.
123. Coumans AB, Huijgens PC, Jakobs C, et al. Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion. Hum Reprod. 1999;14:211-214.
124. Grandone E, Margaglione M, Colaizzo D, et al. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses. Thromb Haemost. 1997;77:822-824.
125. Ridker PM, Miletich JP, Buring JE, et al. Factor V Leiden mutation as a risk factor for recurrent pregnancy loss. Ann Intern Med. 1998;128:1000-1003.
126. Mowbray JF, Gibbings C, Liddell H, et al. Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells. Lancet. 1985;1:941-943.
127. Recurrent Miscarriage Immunotherapy Trials Group. World-wide collaborative observational study and meta-analysis on allogenic leukocyte immunotherapy for recurrent spontaneous abortion. Am J Reprod Immunol. 1985;32:55.
128. Fraser EJ, Grimes DA, Schulz KF. Immunization as therapy for recurrent spontaneous abortion: a review and meta-analysis. Obstet Gynecol. 1993;82:854-859.
129. Ober C, Karrison T, Odem RR, et al. Mononuclear-cell immunisation in prevention of recurrent miscarriages: a randomised trial. Lancet. 1999;354:365-369.
130. CBER Letter. Lymphocyte Immune Therapy (LIT) [http: and www.fda.gov/cber/ltr/lit013002.htm]. Microbiology relevant to recurrent miscarriage. Clin Obstet Gynaecol. 1994;37:722.
131. Aldrich CL, Stephenson MD, Karrison T, et al. HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage. Mol Hum Reprod. 2001;7:1167-1172.
132. Ober C, Aldrich CL, Chervoneva I, et al. Variation in the HLA-G promoter region influences miscarriage rates. Am J Hum Genet. 2003;72:1425-1435.
133. Kline J, Shrout P, Stein Z, et al. Drinking during pregnancy and spontaneous abortion. Lancet. 1980;2:176-180.
134. Ness RB, Grisso JA, Hirschinger N, et al. Cocaine and tobacco use and the risk of spontaneous abortion. N Engl J Med. 1999;340:333-339.
135. Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med. 1999;341:1639-1644.
136. Harlap S, Shiono PH. Alcohol, smoking, and incidence of spontaneous abortions in the first and second trimester. Lancet. 1980;2:173-176.
137. Armstrong BG, McDonald AD, Sloan M. Cigarette, alcohol, and coffee consumption and spontaneous abortion. Am J Public Health. 1992;82:85-87.
138. Halmesmaki E, Valimaki M, Roine R, et al. Maternal and paternal alcohol consumption and miscarriage. Br J Obstet Gynaecol. 1989;96:188-191.
139. Parazzini F, Bocciolone L, La Vecchia C, et al. Maternal and paternal moderate daily alcohol consumption and unexplained miscarriages. Br J Obstet Gynaecol. 1990;97:618-622.
140. Savitz DA, Sonnenfeld NL, Olshan AF. Review of epidemiologic studies of paternal occupational exposure and spontaneous abortion. Am J Ind Med. 1994;25:361-383.
141. Nelson DB, Grisso JA, Joffe MM, et al. Violence does not influence early pregnancy loss. Fertil Steril. 2003;80:1205-1211.
142. Stray-Pedersen B, Stray-Pedersen S. Recurrent abortion: the role of psychotherapy. In: Beard RW, Sharp F, eds. Early Pregnancy Loss: Mechanism and Treatment. London: Springer-Verlag; 1988:433.
143. Liddell HS, Pattison NS, Zanderigo A. Recurrent miscarriage - outcome after supportive care in early pregnancy. Aust N Z J Obstet Gynaecol. 1991;31:320-322.
144. Houwert-de Jong MH, Termijtelen A, Eskes TK, et al. The natural course of habitual abortion. Eur J Obstet Gynecol Reprod Biol. 1989;33:221-228.
145. Clifford K, Rai R, Regan L. Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod. 1997;12:387-389.