Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents

Biochemical Pharmacology

Volumn 73, Issue 7, 2007, Pages 981-989

  Yamada, Taro ^a   Komoto, Junichi ^a   Lou, Kaiyan ^b   Ueki, Akiharu ^b   Hua, Duy H ^b   Sugiyama, Kimio ^c   Takata, Yoshimi ^a,d   Ogawa, Hirofumi ^d   Takusagawa, Fusao ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

^c SHIZUOKA UNIVERSITY   (Japan)

^d UNIVERSITY OF TOYAMA   (Japan)

Author keywords

3 Deaza analogue; Chemical synthesis; Cholesterol reduction; Enzyme inhibition; Eritadenine; S Adenosylhomocysteine hydrolase

Indexed keywords

4 (3 DEAZAADENIN 9 YL) 2,3 DIHYDROXYBUTANOIC ACID; ADENOSINE DEAMINASE; ADENOSYLHOMOCYSTEINASE; ADENOSYLHOMOCYSTEINASE INHIBITOR; CHOLESTEROL; ERITADENINE; GLYCOSIDE; HYPOCHOLESTEROLEMIC AGENT; METHYL 4 (3 DEAZAADENIN 9 YL) 2,3 DIHYDROXYBUTANOATE; N METHYL 4 (3 DEAZAADENIN 9 YL) 2,3 DIHYDROXYBUTANAMIDE; PHOSPHOLIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL BOND; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEAMINATION; DRUG BINDING SITE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; IN VIVO STUDY; LIPID ANALYSIS; MALE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; TRIACYLGLYCEROL BLOOD LEVEL; X RAY DIFFRACTION;

ADENINE; ADENOSYLHOMOCYSTEINASE; ANIMALS; ANTICHOLESTEREMIC AGENTS; RATS; S-ADENOSYLHOMOCYSTEINE; SUBSTRATE SPECIFICITY;

EID: 33847127806     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.12.014     Document Type: Article

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