Eritadenine-induced Alterations of Plasma Lipoprotein Lipid Concentrations and Phosphatidylcholine Molecular Species Profile in Rats Fed Cholesterol-free and Cholesterol-enriched Diets

Bioscience, Biotechnology and Biochemistry

Volumn 67, Issue 5, 2003, Pages 996-1006

  Shimada, Yasuhiko ^a   Morita, Tatsuya ^a   Sugiyama, Kimio ^a  

^a SHIZUOKA UNIVERSITY   (Japan)

Author keywords

Cholesterol; Eritadenine; Linoleic acid metabolism; Phosphatidylcholine; 6 desaturase

Indexed keywords

ACYL COENZYME A DESATURASE; ADENINE; CHOLINE; DIACYLGLYCEROL; DRUG DERIVATIVE; ERITADENINE; HYPOCHOLESTEROLEMIC AGENT; LINOLEOYL COENZYME A DESATURASE; LIPOPROTEIN; LIPOTROPIC AGENT; PHOSPHATIDYLCHOLINE; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; CHOLESTEROL INTAKE; DIET; DRUG EFFECT; EATING; GROWTH; LIVER; LIVER MICROSOME; MALE; METABOLISM; ORGAN SIZE; RAT; WISTAR RAT;

ADENINE; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL, DIETARY; CHOLINE; DIET; DIGLYCERIDES; EATING; FATTY ACID DESATURASES; GROWTH; LINOLEOYL-COA DESATURASE; LIPOPROTEINS; LIPOPROTEINS, VLDL; LIPOTROPIC AGENTS; LIVER; MALE; MICROSOMES, LIVER; ORGAN SIZE; PHOSPHATIDYLCHOLINES; RATS; RATS, WISTAR;

EID: 1542440250     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.67.996     Document Type: Article

References (57)

1. Kaneda, T., and Tokuda, S., Effect of various mushroom preparations on cholesterol metabolism. J. Nutr., 90, 371-376 (1966).
2. Chibata, I., Okumura, K., Takeyama, S., and Kotera, K., Lentinacin: a new hypolipidemic substance in Lentinus edodes. Experientia, 25, 1237-1238 (1969).
3. Rokujo, T., Kikuchi, H., Tensho, A., Tsukitani, Y., Takenawa, T., Yoshida, K., and Kamiya, T., Lenti-sine: a new hypolipidemic agent from a mushroom. Life Sci., 9, 379-385 (1970).
4. Takashima, K., Izumi, K., Iwai, H., and Takeyama, S., The hypocholesterolemic action of eritadenine in the rat. Atherosclerosis, 17, 491-502 (1973).
5. Takashima, K., Sato, C., Sasaki, Y., Morita, T., and Takeyama, S., Effect of eritadenine on cholesterol metabolism in the rat. Biochem. Pharmacol., 23, 433-438 (1974).
6. Sugiyama, K., Akachi, T., and Yamakawa, A., The hypocholesterolemic action of Lentinus edodes is evoked through alteration of phospholipid composition of liver microsomes in rats. Biosci. Biotechnol. Biochem., 57, 1983-1985 (1993).
7. Sugiyama, K., Akachi, T., and Yamakawa, A., Eritadenine-induced alteration of hepatic phospholipid metabolism in relation to its hypocholestero-lemic action in rats. J. Nutr. Biochem., 6, 80-87 (1995).
8. Sugiyama, K., Akachi, T., and Yamakawa, A., Hypocholesterolemic action of eritadenine is mediated by a modification of hepatic phospholipid metabolism in rats. J. Nutr., 125, 2134-2144 (1995).
9. Sugiyama, K., and Yamakawa, A., Dietary eritadenine-induced alteration of molecular species composition of phospholipids in rats. Lipids, 31, 399-404 (1996).
10. Sugiyama, K., Yamakawa, A., Kawagishi, H., and Saeki, S., Dietary eritadenine modifies plasma phosphatidylcholine molecular species profile in rats fed different types of fat. J. Nutr., 127, 593-599 (1997).
11. Sugiyama, K., Yamakawa, A., and Saeki, S., Correlation of suppressed linoleic acid metabolism with the hypocholesterolemic action of eritadenine in rats. Lipids, 32, 859-866 (1997).
12. Terpstra, A. H. M., Woodward, C. J. H., and Sanchez-Munitz, F. J., Improved techniques for the separation of serum lipoproteins by density gradient ultracentrifugation: visualization by prestaining and rapid separation of serum lipoproteins from small volumes of serum. Anal. Biochem., 111, 149-157 (1981).
13. Terpstra, A. H. M., van Tintelen, G., and West, C. E., The hypocholesterolemic effect of dietary soy protein in rats. J. Nutr., 112, 810-817 (1982).
14. Folch, J., Lees, M., and Sloane-Stanley, G. H., A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem., 226, 478-509 (1957).
15. Zak, B., Simple rapid microtechnic for serum total cholesterol. Am. J. Clin. Pathol., 27, 583-588 (1957).
16. Fletcher, M. J., A colorimetric method for estimating serum triglycerides. Clin. Chim. Acta, 22, 393-397 (1968).
17. Bartlett, G. R., Phosphorus assay in column chromatography. J. Biol. Chem., 234, 466-468 (1959).
18. Blank, M. L., Robinson, M., Fitzgerald, V., and Snyder, F., Novel quantitative method for determination of molecular species of phosdpholipids and diglycerides. J. Chromatogr., 298, 473-482 (1984).
19. Takamura, H., Narita, H., Urade, R., and Kito, M., Quantitative analysis of polyenoic molecular species by high performance liquid chromatography. Lipids, 21, 356-361 (1986).
20. Svensson, L., The effect of dietary partially hydrogenated marine oils on desaturation of fatty acids in rat liver microsomes. Lipids, 18, 171-178 (1983).
21. Venkatesan, S., Ward, R. J., and Peters, T. J., Effect of chronic ethanol feeding on the hepatic secretion of very-low-density lipoproteins. Biochim. Biophys. Acta, 960, 61-66 (1988).
22. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., Protein measurement with the Folin phenol reagent. J. Biol. Chem., 194, 265-275 (1951).
23. Duncan, D. B., Multiple range tests for correlated and heteroscedastic means. Biometrics, 13, 164-176 (1957).
24. Wu, A.-L., and Windmueller, H. G., Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat. J. Biol. Chem., 254, 7316-7322 (1979).
25. Huuskonen, J., and Ehnholm, C., Phospholipid transfer protein in lipid metabolism. Curr. Opin. Lipidol., 11, 285-289 (2000).
26. Delong, C. J., Shen, Y.-J., Thomas, M. J., and Cui, Z., Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J. Biol. Chem., 274, 29683-29688 (1999).
27. Schmid, P. C., Johnson, S. B., and Schmid, H. O. C., Remodeling of rat hepatocyte phospholipids by selective acyl turnover. J. Biol. Chem., 266, 13690-13697 (1991).
28. MacDonald, J. I. S., and Sprecher, H., Phosholipid fatty acid remodeling in mammalian cells. Biochim. Biophys. Acta, 1084, 105-121 (1991).
29. Tijburg, L. B. M., Samborski, R. W., and Vance, D. E., Evidence that remodeling of the fatty acids of phosphatidylcholine is regulated in isolated rat hepatocytes and involves both the sn-1 and sn-2 positions. Biochim. Biophys. Acta, 1085, 184-190 (1991).
30. Leikin, A. I., and Brenner, R. R., Cholesterol-induced microsomal changes modulate desaturase activity. Biochim. Biophys. Acta, 922, 294-303 (1987).
31. Leikin, A. I., and Brenner, R. R., In vivo cholesterol removal from liver microsomes induces changes in fatty acid desaturase activity. Biochim. Biophys. Acta, 963, 311-319 (1988).
32. Leikin, A. I., and Brenner, R. R., In vivo phospholipid modification induces changes in microsomal D5-desaturase activity. Biochim. Biophys. Acta, 1165, 189-193 (1992).
33. Lee, J. H., Ikeda, I., and Sugano, M., Dietary cholesterol influences on various lipid indices and eicosanoid production in rats fed dietary fat desirable for the protection of ischemic heart disease. J. Nutr. Sci. Vitaminol., 37, 389-399 (1991).
34. Cho, H. P., Nakamura, M. T., and Clarke, S. D., Cloning, expression, and nutritional regulation of the mammalian D-6 desaturase. J. Biol. Chem., 274, 471-477 (1999).
35. Rimoldi, O. J., Finarelli, G. S., and Brenner, R. R., Effects of diabetes and insulin on hepatic D6 desaturase gene expression. Biochem. Biophys. Res. Commun., 283, 323-326 (2001).
36. Brenner, R. R., Bernasconi, A. M., Gonzalez, M. S., and Rimoldi, O. J., Dietary cholesterol modulates D6 and D9 desaturase mRNAs and enzymatic activity in rats fed a low-EFA diet. Lipids, 37, 375-383 (2002).
37. Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M., Goldstein, J. L., and Rawson, R. B., Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science, 296, 879-883 (2002).
38. 6-desaturase gene expression by SREBP-1 and PPARa J. Lipid Res., 43, 107-114 (2002).
39. Tokuda, S., Kano, E., and Kaneda, T., Effect of mushrooms on cholesterol metabolism in rats (VIII). Reducing mechanism of plasma cholesterol by mushroom (II). Eiyo to Shokuryo (in Japanese), 25, 609-613 (1972).
40. Tokuda, S., Sugawara, Y., and Kaneda, T., Effect of mushrooms on cholesterol metabolism in rats (IX). Reducing mechanism of plasma cholesterol by mushroom (III). Eiyo to Shokuryo (in Japanese), 26, 113-119 (1973).
41. Kurihara, H., and Michi, K., Effect of hypocholesterolemic substance in Shiitake on sterol metabolism in rat. Eiyo to Shokuryo (in Japanese), 25, 458-461 (1972).
42. Brown, M., and Goldstein, J., A receptor-mediated pathway for cholesterol homeostasis. Science, 232, 37-47 (1986).
43. Kadowaki, H., Patton, G. M., and Robins, S. J., Effect of phosphatidylcholine molecular species on the uptake of HDL triglycerides and cholesteryl esters by the liver. J. Lipid Res., 34, 180-189 (1993).
44. Kadowaki, H., Patton, G. M., and Robins, S. J., Metabolism of high density lipoprotein lipids by the rat liver: evidence for participation of hepatic lipase in the uptake of cholesteryl ester. J. Lipid Res., 33, 1689-1698 (1992).
45. Marques-Vidal, P., Azema, C., Collet, X., Vieu, C., Chap, H., and Perret, B., Hepatic lipase promotes the uptake of HDL esterified cholesterol by the perfused rat liver: a study using reconstituted HDL particles of defined phospholipid composition. J. Lipid Res., 35, 373-384 (1994).
46. Tansey, J. T., Thuren, T. Y., Jerome, W. G., Hantgan, R. R., Grant, K., and Waite, M., Hydrolysis of phosphatidylcholine by hepatic lipase in discoidal and spheroidal recombinant high-density lipoprotein. Biochemistry, 36, 12227-12234 (1997).
47. Lambert, G., Chase, M. B., Dugi, K., Bensadoun, A., Brewer, H. B., and Santamarina-Fojo, S., Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1. J. lipid Res., 40, 1294-1303 (1999).
48. Dugi, K. A., Amar, M. J. A., Haudenschild, C. C., Shamburek, R. D., Bensadoun, A., Hoyt, R. F., Fruchart-Najib, J., Madj, Z., Brewer, H. B., and Santamarina-Fojo, S., In vivo evidence for both lipolytic and nonlipolytic function of hepatic lipase in the metabolism of HDL. Arterioscler. Thromb. Vasc. Biol., 20, 793-800 (2000).
49. Ross, A. C., and Zilversmit, D. B., Chylomicron remnant cholesteryl esters as the major constituent of very low density lipoprotein in plasma of cholesterol-fed rabbits. J. Lipid Res., 18, 169-181 (1977).
50. Sultan, F., Lagrange, D., Jansen, H., and Griglio, S., Inhibition of hepatic lipase activity impairs chylomicron remnant-removal in rats. Biochim. Biophys. Acta, 1042, 150-152 (1990).
51. Shafi, S., Brady, S. E., Bensadoun, A., and Havel, R. J., Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver. J. Lipid Res., 35, 709-720 (1994).
52. Chang, S., and Borensztajn, J., Hepatic lipase function and the accumulation of b-very-low-density lipoprotein in the plasma of cholesterol-fed rabbits. Biochem. J., 293, 745-750 (1993).
53. Crawford, S. E., and Borensztajn, J., Plasma clearance and liver uptake of chylomicron remnants generated by hepatic lipase lipolysis: evidence for a lac-toferrin-sensitive and apolipoprotein E-independent pathway. J. Lipid Res., 40, 797-805 (1999).
54. Diard, P., Malewiak, M. I., Lagrange, D., and Griglio, S., Hapatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes. Biochem. J., 299, 889-894 (1994).
55. Ji, Z. S., Dichek, H. L., Miranda, R. D., and Mahley, R. W., Heparan sulfate proteoglycans participate in hepatic lipase and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins. J. Biol. Chem., 272, 31285-31292 (1997).
56. Amar, M. J. A., Dugi, K. A., Haudenschild, C. C., Shamburek, R. D., Foger, B., Chase, M., Bensadoun, A., Hoyt, R. F., Brewer, H. B., and Santamarina-Fojo, S., Hepatic lipase facilitates the selective uptake of cholesteryl estyers from remnant lipoproteins in apoE-deficient mice. J. Lipid Res., 39, 2436-2442 (1998).
57. Bravo, E., Ortu, G., Cantafora, A., Lambert, M. S., Avella, M., Mayes, P. A., and Botham, K. M., Comparison of the hepatic uptake and processing of cholesterol from chylomicrons of different fatty acid composition in the rat in vivo. Biochim. Biophys. Acta, 1258, 328-336 (1995).