Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 6, 2007, Pages 1565-1569

  Carato, Pascal ^a   Graulich, Amaury ^b   Jensen, Niels ^c   Roth, Bryan L ^c   Liégeois, Jean François ^b  

^a UNIV LILLE   (France)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT2A receptors; Antagonist; D4.2 receptors; Schizophrenia

Indexed keywords

ALKYL GROUP; AMIDE; CARBOXYL GROUP; DOPAMINE D2L RECEPTOR; DOPAMINE D4.2 RECEPTOR; DOPAMINE RECEPTOR; NAPHTHALENE DERIVATIVE; NITROGEN; PIPERIDINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BINDING, COMPETITIVE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; INDICATORS AND REAGENTS; NAPHTHALENES; NITROGEN; PIPERIDINES; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847119961     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.096     Document Type: Article

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