Differential mechanisms of transcriptional regulation of the mouse osteocalcin gene by Jun family members

Calcified Tissue International

Volumn 80, Issue 2, 2007, Pages 123-131

  Akhouayri, O ^a   St Arnaud, R ^a,b  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

NAC; AP 1; c Jun; JunB; JunD; Osteocalcin

Indexed keywords

OSTEOCALCIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FRA 2;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; ENZYME ACTIVATION; GENE CONTROL; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; GENE EXPRESSION REGULATION; MICE; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; OSTEOCALCIN; PROTO-ONCOGENE PROTEINS C-JUN; RESPONSE ELEMENTS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 33847118035     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-006-0102-7     Document Type: Article

References (50)

1. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G (1996) Increased bone formation in osteocalcin-deficient mice. Nature 382:448-452
2. Banerjee C, McCabe LR, Choi JY, Hiebert SW, Stein JL, Stein GS, Lian JB (1997) Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex. J Cell Biochem 66:1-8
3. Ducy P, Karsenty G (1995) Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 15:1858-1869
4. Xiao G, Jiang D, Ge C, Zhao Z, Lai Y, Boules H, Phimphilai M, Yang X, Karsenty G, Franceschi RT (2005) Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem 280:30689-30696
5. Yang X, Matsuda K, Bialek P, Jacquot S, Masuoka HC, Schinke T, Li L, Brancorsini S, Sassone-Corsi P, Townes TM, Hanauer A, Karsenty G (2004) ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: implication for Coffin-Lowry syndrome. Cell 117:387-398
6. Owen TA, Bortell R, Yocum SA, et al.(1990) Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription. Proc Natl Acad Sci USA 87:9990-9994
7. Ozono K, Liao J, Kerner SA, Scott RA, Pike JW (1990) The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer. J Biol Chem 265:21881-21888
8. Aslam F, Shalhoub V, van Wijnen AJ, Banerjee C, Bortell R, Shakoori AR, Litwack G, Stein JL, Stein GS, Lian JB (1995) Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription. Mol Endocrinol 9:679-690
9. Meyer T, Carlstedt-Duke J, Starr DB (1997) A weak TATA box is a prerequisite for glucocorticoid-dependent repression of the osteocalcin gene. J Biol Chem 272:30709-30714
10. Hoffmann HM, Beumer TL, Rahman S, McCabe LR, Banerjee C, Aslam F, Tiro JA, van Wijnen AJ, Stein JL, Stein GS, Lian JB (1996) Bone tissue-specific transcription of the osteocalcin gene: role of an activator osteoblast-specific complex and suppressor hox proteins that bind the OC box. J Cell Biochem 61:310-324
11. Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS, Stein JL (1994) Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins. Proc Natl Acad Sci USA 91:12887-12891
12. Newberry EP, Latifi T, Towler DA (1998) Reciprocal regulation of osteocalcin transcription by the homeodomain proteins Msx2 and Dlx5. Biochemistry 37:16360-16368
13. Towler DA, Rutledge SJ, Rodan GA (1994) Msx-2/Hox 8.1: a transcriptional regulator of the rat osteocalcin promoter. Mol Endocrinol 8:1484-1493
14. Aslam F, McCabe L, Frenkel B, van Wijnen AJ, Stein GS, Lian JB, Stein JL (1999) AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation. Endocrinology 140:63-70
15. Banerjee C, Stein JL, Van Wijnen AJ, Frenkel B, Lian JB, Stein GS (1996) Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site. Endocrinology 137:1991-2000
16. Goldberg D, Polly P, Eisman JA, Morrison NA (1996) Identification of an osteocalcin gene promoter sequence that binds AP1. J Cell Biochem 60:447-457
17. McCabe LR, Banerjee C, Kundu R, Harrison RJ, Dobner PR, Stein JL, Lian JB, Stein GS (1996) Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation: role of Fra-2 and JunD during differentiation. Endocrinology 137:4398-4408
18. Owen TA, Aronow M, Shalhoub V, Barone LM, Wilming L, Tassinari MS, Kennedy MB, Pockwinse S, Lian JB, Stein GS (1990) Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 143:420-430
19. Owen TA, Bortell R, Shalhoub V, Heinrichs A, Stein JL, Stein GS, Lian JB (1993) Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein-DNA interactions at basal and enhancer promoter elements. Proc Natl Acad Sci USA 90:1503-1507
20. Schule R, Umesono K, Mangelsdorf DJ, Bolado J, Pike JW, Evans RM (1990) Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene. Cell 61:497-504
21. Wagner EF, Eferl R (2005) Fos/AP-1 proteins in bone and the immune system. Immunol Rev 208:126-140
22. Angel PE, Herrlich PA (1994) The Fos and Jun Families of Transcription Factors. CRC Press, Boca Raton
23. Hartl M, Bader AG, Bister K (2003) Molecular targets of the oncogenic transcription factor jun. Curr Cancer Drug Targets 3:41-55
24. Boumah CE, Selvamurugan N, Partridge NC (2005) Transcription in the osteoblast: regulatory mechanisms utilized by parathyroid hormone and transforming growth factor-beta. Prog Nucleic Acid Res Mol Biol 80:287-321
25. Hipskind RA, Bilbe G (1998) MAP kinase signaling cascades and gene expression in osteoblasts. Front Biosci 3:d804-d816
26. Lian JB, Stein GS, Stein JL, van Wijnen AJ (1998) Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation. J Cell Biochem Suppl 31:62-72
27. McCabe LR, Kockx M, Lian J, Stein J, Stein G (1995) Selective expression of fos- and jun-related genes during osteoblast proliferation and differentiation. Exp Cell Res 218:255-262
28. Eferl R, Hoebertz A, Schilling AF, Rath M, Karreth F, Kenner L, Amling M, Wagner EF (2004) The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J 23:2789-2799
29. Kenner L, Hoebertz A, Beil T, Keon N, Karreth F, Eferl R, Scheuch H, Szremska A, Amling M, Schorpp-Kistner M, Angel P, Wagner EF (2004) Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol 164:613-623
30. Jochum W, David JP, Elliott C, Wutz A, Plenk H Jr, Matsuo K, Wagner EF (2000) Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med 6:980-984
31. Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R (2000) Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med 6:985-990
32. Akhouayri O, Quelo I, St-Arnaud R (2005) Sequence-specific DNA binding by the αNAC coactivator is required for potentiation of c-Jun-dependent transcription of the osteocalcin gene. Mol Cell Biol 25:3452-3460
33. Yotov WV, Moreau A, St-Arnaud R (1998) The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator. Mol Cell Biol 18:1303-1311
34. Moreau A, Yotov WV, Glorieux FH, St-Arnaud R (1998) Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription. Mol Cell Biol 18:1312-1321
35. Quelo I, Akhouayri O, Prud-homme J, St-Arnaud R (2004) GSK3ß-dependent phosphorylation of the αNAC coactivator regulates its nuclear translocation and proteasome-mediated degradation. Biochemistry 43:2906-2914
36. Quelo I, Hurtubise M, St-Arnaud R (2002) αNAC requires an interaction with c-Jun to exert its transcriptional coactivation. Gene Expr 10:255-262
37. Ryder K, Lanahan A, Perez-Albuerne E, Nathans D (1989) jun-D: a third member of the jun gene family. Proc Natl Acad Sci USA 86:1500-1503
38. Ryder K, Lau LF, Nathans D (1988) A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci USA 85:1487-1491
39. Courey AJ, Tjian R (1988) Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55:887-898
40. Yotov WV, St-Arnaud R (1996) Differential splicing-in of a proline-rich exon converts αNAC into a muscle-specific transcription factor. Genes Dev 10:1763-1772
41. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (1993) Current Protocols in Molecular Biology. John Wiley and Sons, New York
42. Dignam JD, Lebovitz RM, Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489
43. Candeliere GA, Jurutka PW, Haussler MR, St-Arnaud R (1996) A composite element binding the vitamin D receptor, retinoid X receptor alpha, and a member of the CTF/NF-1 family of transcription factors mediates the vitamin D responsiveness of the c-fos promoter. Mol Cell Biol 16:584-592
44. Sudo H, Kodama HA, Amagai Y, Yamamoto S, Kasai S (1983) In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 96:191-198
45. Xiao G, Cui Y, Ducy P, Karsenty G, Franceschi RT (1997) Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol 11:1103-1113
46. Ryoo HM, Hoffmann HM, Beumer T, Frenkel B, Towler DA, Stein GS, Stein JL, van Wijnen AJ, Lian JB (1997) Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression. Mol Endocrinol 11:1681-1694
47. Quelo I, Gauthier C, Hannigan GE, Dedhar S, St-Arnaud R (2004) Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency. J Biol Chem 279:43893-43899
48. Naito J, Kaji H, Sowa H, Hendy GN, Sugimoto T, Chihara K (2005) Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD. J Biol Chem 280:4785-4791
49. 3 inhibits osteocalcin expression in mouse through an indirect mechanism. J Biol Chem 272:110-116
50. Thepot D, Weitzman JB, Barra J, Segretain D, Stinnakre MG, Babinet C, Yaniv M (2000) Targeted disruption of the murine junD gene results in multiple defects in male reproductive function. Development 127:143-153