Bone tissue-specific transcription of the osteocalcin gene: Role of an activator osteoblast-specific complex and suppressor Hox proteins that bind the OC box

Journal of Cellular Biochemistry

Volumn 61, Issue 2, 1996, Pages 310-324

  Hoffmann, H M ^a   Beumer, T L ^a   Rahman, S ^a   McCabe, L R ^a   Banerjee, C ^a   Aslam, F ^a   Tiro, J A ^a   Van Wijnen, A J ^a   Stein, J L ^a   Stein, G S ^a   Lian, J B ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

bone specific; homeodomain protein; Msx; OC box; osteocalcin; transcriptional regulation

Indexed keywords

OSTEOCALCIN;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; CELL DIFFERENTIATION; HEAT; HELA CELLS; HOMEODOMAIN PROTEINS; HUMANS; MUTATION; NUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; OSTEOBLASTS; OSTEOCALCIN; PROMOTER REGIONS (GENETICS); RATS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 9244244171     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19960501)61:2<310::AID-JCB14>3.0.CO;2-P     Document Type: Article

References (60)

1. Ambesi-Impiombato PS, Perrild H (1989): "FRTL-5 Today." Elsevier Publishers B.V.
2. Aronow MA, Gerstenfeld LC, Owen TA, Tassinari MS, Stein GS, Lian JB (1990): Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells. J Cell Physiol 143:213-221.
3. Aslam F, Shalhoub V, van Wijnen AJ, Banerjee C, Bortell R, Shakoori AR, Litwack G, Stein JL, Stein GS, Lian JB (1995): Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription. Mol Endocrinol 9:679-690.
4. Ausubel FM, Brent R, Kingston RE, Moore DE, Seidman JG, Smith JA, Struhl K (1989): "Current Protocols in Molecular Biology." New York: Greene and Wiley.
5. Baker AR, Hollingshead PG, Pitts-Meek S, Hansen S, Taylor R, Stewart TA (1992): Osteoblast-specific expression of growth hormone stimulates bone growth in transgenic mice. Mol Cell Biol 12:5541-5547.
6. Banerjee C, Stein JL, van Wijnen AJ, Frenkel B, Lian JB, Stein GS: TGF-β1 responsiveness of the rat osteocalcin gene is mediated by an AP-1 binding site. Endocrinology, in press.
7. Bellows CG, Aubin JE, Heersche JN, Antosz ME (1986): Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations. Calcif Tissue Int 38:143-154.
8. Bidwell JP, van Wijnen AJ, Fey EG, Dworetzky S, Penman S, Stein JL, Lian JB, Stein GS (1993): Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components. Proc Natl Acad Sci USA 90:3162-3166.
9. Bobola N, Hirsch E, Albini A, Altruda F, Noonan D, Ravazzolo R (1995): A single cis-acting element in a short promoter segment of the gene encoding the interphotoreceptor retinoid-binding protein confers tissue-specific expression. J Biol Chem 270:1289-1294.
10. Bortell R, Owen TA, Bidwell JP, Gavazzo P, Breen E, van Wijnen AJ, DeLuca HF, Stein JL, Lian JB, Stein GS (1992): Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression. Proc Natl Acad Sci USA 89:6119-6123.
11. Catron KM, Iler N, Abate C (1993): Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three marine homeodomain proteins. Mol Cell Biol 13:2354-2365.
12. Catron KM, Zhang H, Marshall SC, Inostroza JA, Wilson JM, Abate C (1995): Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites. Mol Cell Biol 15:861-871.
13. Cuif MH, Cognet M, Boquet D, Tremp G, Kahn A, Vaulont S (1992): Elements responsible for hormonal control and tissue specificity of L type pyruvate kinase gene expression in transgenic mice. Mol Cell Biol 12:4852-4861.
14. 3. Proc Natl Acad Sci USA 87:369-373.
15. Dodig M, Kronenburg MS, Kream B, Pan Z, Upholt WB, Lichtler AC (1995): Msx-2 inhibits Col1A1 Promoter-CAT construct expression in osteoblastic cells. J Bone Miner Res 10:S421.
16. Ducy P, Karsenty G (1995): Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 15:1858-1869.
17. Dynlacht BD, Hoey T, Tjian R (1991): Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. Cell 66:563-576.
18. Frenkel B, Montecino M, Aslam F, Desai R, Green J, Stein JL, Lian JB, Stein GS (1996): Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: Requirement of upstream sequences for control by the proximal regulatory domain. Endocrinology 137:1080-1088.
19. Freytag S, Paielli DL, Gilbert JD (1994): Ectopic expression of the CCAAT/enhancer-binding protein a promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev 8:1654-1663.
20. Gehring WJ, Affolter M, Burglin T (1994): Homeodomain proteins. Annu Rev Biochem 63:487-526.
21. German CM, Moffat LF, Howard BH (1982): Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 2:1044-1051.
22. Gundberg CM, Hauschka PV, Lian JB, Gallop PM (1984): Osteocalcin isolation, characterization and detection. Methods Enzymol 173:534-545.
23. Heinrichs AAJ, Banerjee C, Bortell R, Owen TA, Stein JL, Stein GS, Lian JB (1993): Identification and characterization of two proximal elements in the rat osteocalcin gene promoter that may confer species-specific regulation. J Cell Biochem 53:240-250.
24. Heinrichs AAJ, Bortell R, Bourke M, Lian JB, Stein GS, Stein JL (1995): Proximal promoter binding protein contributes to developmental, tissue-restricted expression of the rat osteocalcin gene. J Cell Biochem 57:90-100.
25. Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS, Stein JL (1994): Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins. Proc Natl Acad Sci USA 91:12887-12891.
26. Hu Y, Flanagan J, Brennan DP, Zhou H, Ng KW, Eisman JA, Morrison NA (1995): rHox: A homeobox gene expressed in osteoblastic cells. J Cell Biochem 59:486-497.
27. Jabs EW, Muller U, Li X, Ma L, Luo W, Haworth IS, Klisak I, Sparkes R, Warman ML, Mulliken JB, Snead ML, Maxson R (19931: A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell 75:443-450.
28. Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rose V, Wozney JM, Fujisawa-Sehara A, Suda T (1994): Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 127:1755-1766.
29. 3. Proc Natl Acad Sci USA 86:4455-4459.
30. Kodama H, Amagai Y, Sudo H, Kasai S, Yamamoto S (1981): Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn J Oral Biol 23:899-901.
31. Krumlauf R (1994): Hox genes in vertebrate development. Cell 78:191-201.
32. Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE Jr, Crabtree GR (1992): A transcriptional hierarchy involved in mammalian cell-type specification. Nature 355:457-461.
33. Lai E, Darnell JE Jr (1991): Transcriptional control in hepatocytes: A window on development. Trends Biochem Sci 16:427-430.
34. Liu B, Hammer GD, Rubinstein M, Mortrud M, Low MJ (1992): Identification of DNA elements cooperatively activating proopiomelanocortin gene expression in the pituitary glands of transgenic mice. Mol Cell Biol 12:3978-3990.
35. Lynch MP, Stein JL, Stein GS, Lian JB (1995): The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: Modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization. Exp Cell Res 216:35-45.
36. Majeska RJ, Rodan SB, Rodan GA (1980): Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma. Endocrinology 107:1494-1503.
37. Markose ER, Stein JL, Stein GS, Lian JB (1990): Vitamin D-mediated modifications in protein-DNA interactions at two promoter elements of the osteocalcin gene. Proc Natl Acad Sci USA 87:1701-1705.
38. McCabe LR, Banerjee C, Harrison RJ, Dobner PR, Stein JL, Lian JB, Stein G (submitted): Developmental expression and activities of Fos and Jun related proteins is functionally coupled to osteoblast differentiation. Submitted.
39. Merriman HL, van Wijnen AJ, Hiebert S, Bidwell JP, Fey E, Lian J, Stein J, Stein G (1995): The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/PEBP2/ Runt domain transcription factor family: Interactions with the osteocalcin gene promoter. Biochemistry 34:13125-13132.
40. Olson EN, Klein WH (1994): bHLH factors in muscle development: Deadlines and commitments, what to leave in and what to leave out. Genes Dev 8:1-8.
41. Owen TA, Aronow M, Shalhoub V, Barone LM, Wilming L, Tassinari MS, Kennedy MB, Pockwinse S, Lian JB, Stein GS (1990): Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 143:420-430.
42. 3 enriched in cloned osteoblast-like rat osteogenic sarcoma cells. FEBS Lett 115:139-142.
43. Puck TT, Marcus PI, Cieciura SJ (1956): Clonal growth of mammalian cells in vitro. Growth characteristics of colonies from single HeLa cells with and without "feeder" layer. J Exp Med 103:273-284.
44. Rodan GA, Noda M (1991): Gene expression in osteoblastic cells. Crit Rev Eukary Gene Expression 1:85-98.
45. Rodan SB, Majeska RJ, Rodan GA (1993): Osteosarcoma cells as models for osteoblasts. In Novak JF, McMaster JH (eds): "Frontiers of Osteosarcoma Research." Seattle: Hogrefe and Huber Publishers, pp 193-203.
46. Rosen V, Nove J, Song JJ, Thais RS, Cox K, Wozney JM (1994): Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes. J Bone Miner Res 9:1759-1768.
47. Satokata I, Maas R (1994): Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nature Genet 6:348-356.
48. Schepmoes G, Breen E, Owen TA, Aronow MA, Stein GS, Lian JB (1991): Influence of dexamethasone on the vitamin D-mediated regulation of osteocalcin gene expression. J Cell Biochem 47:184-196.
49. Shalhoub V, Conlon DM, Tassinari M, Quinn C, Partridge N, Stein GS, Lian JB (1992): Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes. J Cell Biochem 50:425-440.
50. Stanford CM, Jacobson PA, Eanes ED, Lembke LA, Midura RJ (1995): Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-01 BSP). J Biol Chem 270:9420-9428.
51. Stein GS, Lian JB (1993): Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocrin Rev 14:424-442.
52. Tamura M, Noda M (1994): Identification of a DNA sequence involved in osteoblast-specific gene expression via interaction with helix-loop-helix (HLH)-type transcription factors. J Cell Biol 126:773-782.
53. Topp WC (1981): Normal rat cell lines deficient in nuclear thymidine kinase. Virology 113:408-411.
54. Towler DA, Rodan GA (1995): Identification of a rat osteocalcin promoter 3′,5′-cyclic adenosine monophosphate response region containing two PuGGTCA steroid hormone receptor binding motifs. Endocrinology 136:1089-1096.
55. Towler DA, Bennett CD, Rodan GA (1994a): Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs. Mol Endocrinot 8:614-624.
56. Towler DA, Rutledge SJ, Rodan GA (1994b): Msx-2/Hox 8.1: A transcriptional regulator of the rat osteocalcin promoter. Mol Endocrinol 8:1484-1493.
57. Umek R, Friedman A, McKnight SL (1991): CCAAT/ enhancer binding protein: A component of a differentiation switch. Science 251:288-292
58. Vitti P, Valente WA, Ambesi-Impiombato FS, Fenzi GF, Pinchera A, Kohn LD (1982): Graves' IgG stimulation of continuously cultured rat thyroid cells: A sensitive and potentially useful clinical assay. J Endocrinol Invest 5:179-182.
59. Weinmann R (1992): The basic RNA polymerase II transcriptional machinery. Gene Expression 2:81-91.
60. Yeh W-C, Cao Z, Classon M, McKnight SL (1995): Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 9:168-181.