Dry powder aerosol delivery of large hollow nanoparticulate aggregates as prospective carriers of nanoparticulate drugs: Effects of phospholipids

International Journal of Pharmaceutics

Volumn 333, Issue 1-2, 2007, Pages 187-198

  Hadinoto, Kunn ^a   Phanapavudhikul, Ponpan ^a   Kewu, Zhu ^a   Tan, Reginald B H ^a,b  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Dry powder inhaler; Hollow particles; Inhaled drug delivery; Nanoparticulate drugs; Pulmonary delivery; Spray drying

Indexed keywords

DRUG CARRIER; NANOPARTICLE; PHOSPHOLIPID; POLYACRYLIC ACID; SILICON DIOXIDE;

AEROSOL; ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRY POWDER; PARTICLE SIZE; PRIORITY JOURNAL; SPRAY DRYING; SURFACE PROPERTY;

ACRYLATES; ADMINISTRATION, INHALATION; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; NANOPARTICLES; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; PHOSPHOLIPIDS; POROSITY; POWDERS; SILICON DIOXIDE; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 33847102239     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.10.009     Document Type: Article

References (37)

1. Adler M., Unger M., and Lee G. Surface composition of spray-dried particles of bovine serum albumin/trehalose/surfactant. Pharm. Res. 17 (2000) 863-870
2. Ahsan F., Rivas I.P., Khan M.A., and Suarez-Torres A.I. Targeting to macrophages: role of physicochemical properties of particulate carriers-liposomes and microspheres on the phagocytosis by macrophages. J. Controlled Release 79 (2002) 29-40
3. Bosquillon C., Lombry C., Preat V., and Vanbever R. Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance. J. Controlled Release 70 (2001) 329-339
4. Cook R.O., Pannu R.K., and Kellaway I.W. Novel sustained release microspheres for pulmonary drug delivery. J. Controlled Release 104 (2005) 79-90
5. Dellamary L.A., Tarara T.E., Smith D.J., Woelk C.H., Adractas A., Costello M.L., Gill H., and Weers J.G. Hollow porous particles in metered dose inhalers. Pharm. Res. 17 (2000) 168-174
6. Edwards D.A., Hanes J., Caponetti G., Hrkach J., Ben-Jebria A., Eskew M., Mintzes J., Deaver D., Lotan N., and Langer R. Large porous particles for pulmonary drug delivery. Science 276 (1997) 1868-1871
7. Eerikäinen H., Watanabe W., Kauppinen E.I., and Ahonen P.P. Aerosol flow reactor method for synthesis of drug nanoparticles. Eur. J. Pharm. Biopharm. 55 (2003) 357-360
8. Evora C., Soriano I., Rogers R.A., Shakesheff K.M., Hanes J., and Langer R. Relating the phagocytosis of microparticles by alveolar macrophages to surface chemistry: the effect of 1,2-dipalmitoylphosphatidylcholine. J. Controlled Release 1 (1998) 143-152
9. French D.L., Edwards D.A., and Niven R.W. The influence of formulation on emission, deaggregation, and deposition of dry powders for inhalation. J. Aerosol Sci. 27 (1996) 769-783
10. Govender T., Stolnik S., Garnett M.C., Illum L., and Davis S.S. PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. J. Controlled Release 57 (1999) 171-185
11. Grenha A., Seijo B., and Lopez C.R. Microencapsulated chitosan nanoparticles for lung protein delivery. Eur. J. Pharm. Sci. 25 (2005) 427-437
12. Hadinoto K., Phanapavudhikul P., Zhu K., and Tan R.B.H. Novel formulation of large hollow nanoparticles aggregates as potential carriers in inhaled delivery of nanoparticulate drugs. Ind. Eng. Chem. Res. 45 (2006) 3697-3706
13. Hinds W.C. Aerosol Technology (1982), Wiley, New York
14. Hyvönen S., Peltonen L., Karjalainen M., and Hirvonen J. Effect of nanoprecipitation on the physicochemical properties of low molecular weight poly(l-lactic acid) nanoparticles loaded with salbutamol sulphate and beclomethasone dipropionate. Int. J. Pharm. 295 (2005) 269-281
15. Jones B.G., Dickinson P.A., Gumbleton M., and Kellaway I.W. Lung surfactant phospholipids inhibit the uptake of respirable microspheres by the alveolar macrophage NR8383. J. Pharm. Pharmacol. 54 (2002) 1065-1072
16. Kipp J.E. The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. Int. J. Pharm. 284 (2004) 109-122
17. Lalka D., Griffith R.K., and Cronenberger C.L. The hepatic first-pass metabolism of problematic drugs. J. Clin. Pharmacol. 33 (1993) 657-659
18. Lee J.H. Drug nano and microparticles processed into solid dosage forms: physical properties. J. Pharm. Sci. 92 (2003) 2057-2068
19. Li W.I., Perzl M., Heyder J., Langer R., Brain J.D., Englemeier K.H., Niven R.W., and Edwards D.A. Aerodynamics and aerosol particle deaggregation phenomena in model oral-pharyngeal cavities. J. Aerosol Sci. 27 (1996) 1269-1286
20. Liang H., Shinohara K., Minoshima H., and Matsushima K. Analysis of constant rate period of spray drying slurry. Chem. Eng. Sci. 56 (2001) 2205-2213
21. Lukasiewicz S.J. Spray-drying of ceramic powders. J. Am. Ceram. Soc. 72 (1989) 617-624
22. Maa Y.F., Nguyen P.A.T., and Hsu S.W. Spray drying of air-liquid interface sensitive recombinant human growth hormone. J. Pharm. Sci. 87 (1998)
23. Makino K., Yamamoto N., Higuchi K., Harada N., Ohshima H., and Terada H. Phagocytic uptake of polystyrene microspheres by alveolar macrophages: effects of the size and surface properties of the microspheres. Colloid Surf. B 27 (2003) 33-39
24. Montgomery D.C., and Runger G.C. Applied Statistics and Probability for Engineers (1999), John Wiley and Sons, New York pp. 388-394
25. Moon W.S., Chung H.J., Park S.B., and Woo S.I. Effects of lead acetate concentration on the droplet size in liquid source misted chemical decomposition. Thin Solid Films 358 (2000) 86-89
26. Pang Y.N., Sakagami M., and Byron P.R. The pharmacokinetics of pulmonary insulin in the in-vitro isolated perfused rat lung: implications of metabolism and regional deposition. Eur. J. Pharm. Sci. 25 (2005) 369-378
27. Patel A.A., White C.M., and Coleman C.I. Exubera-an orally inhaled insulin. Formulary 40 (2005) 429
28. Phanapavudhikul P., Waters J.A., and Ortiz E.S. Para-magnetic composite microparticles as heavy metal ion-exchangers. Eur. Cells Mater. 3 (2002) 118-121
29. Raula J., Eerikainen H., and Kauppinen E.I. Influence of the solvent composition on the aerosol synthesis of pharmaceutical polymer nanoparticles. Int. J. Pharm. 284 (2004) 13-21
30. Sacchetti M., and Van Oort M.M. In: Hickey A.J. (Ed). Spray Drying and Supercritical Fluid Particle Generation Techniques. Inhalation Aerosols-Physical and Biological Basis for Therapy (1996), Marcel Dekker, New York 337-384
31. Scherer G.W. Theory of drying. J. Am. Ceram. Soc. 73 (1990) 3-14
32. Sham J., Zhang Y., Finlay W.H., Roa W.H., and Lobenberg R. Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung. Int. J. Pharm. 269 (2004) 457-467
33. Shargel L., and Yu A.B. Applied Biopharmaceutics & Pharmacokinetics. fourth ed. (1999), McGraw Hill, New York
34. Steckel H., and Brandes H.G. A novel spray drying technique to produce low density particles for pulmonary delivery. Int. J. Pharm. 278 (2004) 187-195
35. Teixeira M., Alonso M.J., Pinto M.M.M., and Barbosa C.M. Development and characterization of PLGA nanospheres and nanocapsules containing xanthone and 3-methoxyxanthone. Eur. J. Pharm. Biopharm. 59 (2005) 491-500
36. Tsapis N., Bennet D., Jackson B., Weitz D.A., and Edwards D.A. Trojan particles: large porous carriers of nanoparticles for drug delivery. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 12001-12005
37. Vanbever R., Mintzes J., Wang J., Nice J., Chen D., Batycky R., Langer R., and Edwards D.A. Formulation and physical characterization of large porous particles for inhalation. Pharm. Res. 16 (1999) 1735-1742