Characteristics of HIV-1-specific CD8 T-cell responses and their role in loss of viremia in children chronically infected with HIV-1 undergoing highly active antiretroviral therapy

Chinese Medical Journal

Volumn 119, Issue 23, 2006, Pages 1949-1957

  Zhang, Zheng ^a   Zhao, Qing Xia ^b   Fu, Jun Liang ^a   Yao, Jin Xia ^a   He, Yun ^b   Jin, Lei ^a   Wang, Fu Sheng ^a  

^a BEIJING 302 HOSPITAL   (China)

^b Zhengzhou Sixth Hospital   (China)

Author keywords

Child; Cytotoxic T lymphocyte; Dendritic cells; Human immunodeficiency virus

Indexed keywords

ANTIRETROVIRUS AGENT; GAMMA INTERFERON; INDINAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS RNA; EPITOPE;

ADOLESCENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; MALE; PROGNOSIS; VIREMIA; VIRUS LOAD; VIRUS REPLICATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY;

ADOLESCENT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD8-POSITIVE T-LYMPHOCYTES; CHILD; EPITOPES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; T-LYMPHOCYTES, CYTOTOXIC; VIREMIA;

EID: 33847096499     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200612010-00003     Document Type: Article

References (31)

1. UNAIDS/WHO. Report on the global HIV/AIDSEpidemic. Geneva: UNAIDS/WHO, 2004. (Accessed at http://data.unaids.org/globalreport/.)
2. Zhuang K, Gui X, Su B, Tien P, Chen Z, Zhang L. High prevalence of HIV infection among women and their children in Henan province, China. J AIDS 2003; 33: 649-650.
3. Gortmaker SL, Hughes M, Cervia J, Brady M, Johnson GM, Seage GR, et al. Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1. N Engl J Med 2001; 345: 1522-1528.
4. Feeney ME, Tang Y, Pfafferott K, Roosevelt KA, Draenert R, Trocha A, et al. HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response. J Immunol 2005; 174: 7524-7530.
5. Gandhi RT, Walker BD. Immunologic control of HIV-1. Annu Rev Med 2002; 53: 149-172.
6. Ogg GS, Jin X, Bonhoeffer S, Dunbar PR, Nowak MA, Monard S, et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 1998; 279: 2103-2106.
7. Gea-Banacloche JC, Migueles SA, Martino L, Shupert WL, McNeil AC, Sabbaghian MS, et al. Maintenance of large numbers of virus-specific CD8-T cells in HIV-infected progressors and long-term nonprogressors. J Immunol 2000; 165: 1082-1092.
8. + T-cell responses: relationship to viral load in untreated HIV infection. J Virol 2001; 75: 11983-11991.
9. Levy JA. The importance of the innate immune system in controlling HIV infection and disease. Trends Immunol 2001; 22: 312-316.
10. Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 2005; 23: 275-306.
11. + myeloid and CD11c-plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 2001; 98: 2574-2576.
12. Chehimi J, Campbell DE, Azzoni L, Bacheller D, Papasavvas E, Jerandi G, et al. Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J Immunol 2001; 168: 4796-4801.
13. Azzoni L, Rutstein RM, Chehimi J, Farabaugh MA, Nowmos A, Montaner LJ. Dendritic and natural killer cell subsets associated with stable or declining CD4 cell counts in treated HIV-1-infected children. J Infect Dis 2005; 191: 1451-1459.
14. Li L, Bouvier M. Structures of HLA-A*1101 complexed with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle, secondary anchor residue. J Immunol 2004; 172: 6175-6184.
15. Ikeda-Moore Y, Tomiyama H, Miwa K, Oka S, Iwamoto A, Kaneko Y, et al. Identification and characterization of multiple HLA-A24-restricted HIV-1 CTL epitopes: strong epitopes are derived from V regions of HIV-1. J Immunol 1997; 159: 6242-6252.
16. Su B, Liu L, Wang FS, Gui X, Zhao M, Tien P, et al. HIV-1 subtype B' dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China. AIDS 2003; 17: 2515-2520.
17. Tan J, Tang X, Xie T Xu Q, Ding YD. DNA typing for HLA-A, B antigens by polymerase chain reaction with sequence-specific primers and clinical application. Natl Med J Chin (Chin) 1998; 78: 763-767.
18. Buseyne F, Scott-Algara D, Porrot F, Corre B, Bellal N, Burgard M, et al. Frequencies of ex vivo-activated human immunodeficiency virus type 1-specific gamma-interferon-producing CD8 T cells in infected children correlate positively with plasma viral load. J Virol 2002; 76: 12414-12422.
19. Sandberg JK, Fast NM, Jordan KA, Furlan SN, Barbour JD, Fennelly G, et al. HIV-specific CD8 T cell function in children with vertically acquired HIV-1 infection is critically influenced by age and the state of the CD4 T cell compartment. J Immunol 2003; 170: 4403-4410.
20. Zhang Z, Xu D, Li Y, Jin L, Shi M, Wang M, et al. Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Clin Immunol 2005; 116: 225-235.
21. Dunn D; HIV paediatric prognostic markers collaborative study group. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. Lancet 2003; 362: 1605-1611.
22. Spiegel HM, DeFalcon E, Ogg GS, Larsson M, Beadle TJ, Tao P, et al. Changes in frequency of HIV-1-speciic cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children. J Infect Dis 1999; 180: 359-368.
23. Scott-Algara D, Buseyne F, Blanche S, Rouzioux C, Jouanne C, Romagne F, et al. Frequency and phenotyping of human immunodeficiency virus (HIV)-specific CD8 T cells in HIV-infected children, using major histocompatibility complex class I peptide tetramers. J Infect Dis 2001; 183: 1565-1573.
24. Chitnis V, Pahwa R, Pahwa S. Determinants of HIV-specific CD8 T-cell responses in HIV-infected pediatric patients and enhancement of HIV-gag-specific responses with exogenous IL-15. Clin Immunol 2003; 107: 36-45.
25. Borkowsky W, Zhan MX, Chen SH, Ilmet T, Kaul A, Chandwani S, et al. Correlation between HIV-specific CD8 cell production of interferon-γ and plasma levels of HIV RNA in perinatally infected pediatric populations. J Infect Dis 2004; 190: 722-726.
26. Scott-Algara D, Buseyne F, Porrot F, Corre B, Bellal N, Rouzioux C, et al. Not all tetramer binding CD8 T cells can produce cytokines and chemokines involved in the effector functions of virus-specific CD8 T lymphocytes in HIV-1 infected children. J Clin Immunol 2005; 25: 57-67.
27. Lanzavecchia1 A, Sallusto F. Regulation of T cell immunity by dendritic cells. Cell 2001; 106: 263-266.
28. + T cells: a new role for plasmacytoid dendritic cells in adaptive immunity. Blood 2003; 101: 3520-3526.
29. Yoneyama H, Matsuno K, Toda E, Nishiwaki T, Matsuo N, Nakano A, et al. Plasmacytoid DCs help lymph nods DCs to induce anti-HSV CTLs. J Exp Med 2005; 202: 425-435.
30. Teig N, Moses D, Gieseler S, Schauer U. Age-related changes in human blood dendritic cell subpopulations. Scand J Immunol 2002; 55: 453-457.
31. Burns DN, Mofenson LM. Paediatric HIV-1 infection. Lancet 1999; 354 Supple 2: SII1-6.