Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11

Journal of Molecular Biology

Volumn 367, Issue 1, 2007, Pages 212-223

  Liu, Ping ^a   Ewis, Hosam E ^a   Tai, Phang C ^a   Lu, Chung Dar ^a   Weber, Irene T ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

cancer therapy; carboxylesterase; crystal structure; cysteine oxidation; hydrolase

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; BACTERIAL ENZYME; CARBOXYLESTERASE; CYSTEINE; GLUTAMINE; HISTIDINE; IRINOTECAN; MUTANT PROTEIN; PROTEIN EST55; PROTEIN SUBUNIT; SERINE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ARTICLE; BETA CHAIN; CANCER THERAPY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVATION; DRUG HYDROLYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME METABOLISM; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBUNIT; GEOBACILLUS STEAROTHERMOPHILUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; THERMOSTABILITY;

BACTERIA (MICROORGANISMS); GEOBACILLUS STEAROTHERMOPHILUS; MAMMALIA;

EID: 33847082199     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.12.067     Document Type: Article

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