Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1773, Issue 3, 2007, Pages 383-390

  Jung, Yunjin ^a   Xu, Wanping ^b   Kim, Heejung ^a   Ha, Namchul ^a   Neckers, Len ^b  

^a Pusan National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Curcumin; E3 ubiquitin ligase; ErbB2; Michael reaction; Molecular chaperones

Indexed keywords

BORTEZOMIB; CHAPERONE; CURCUMIN; DELTA12 PROSTAGLANDIN J2; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELDANAMYCIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PARTHENOLIDE; PROTEASOME; PROTEASOME INHIBITOR; TETRAHYDROCURCUMIN; TRITIUM; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN COS7; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME DEGRADATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; ISOTOPE LABELING; MICHAEL ADDITION; NONHUMAN; PLASMID; PRIORITY JOURNAL; UBIQUITINATION; WESTERN BLOTTING;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CURCUMIN; HUMANS; MOLECULAR CHAPERONES; MOLECULAR STRUCTURE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RECEPTOR, ERBB-2; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 33847066743     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2006.11.004     Document Type: Article

References (20)

1. Olayioye M.A., Neve R.M., Lane H.A., and Hynes N.E. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 19 (2000) 3159-3167
2. Anderson N.G., and Ahmad T. ErbB receptor tyrosine kinase inhibitors as therapeutic agents. Front. Biosci. 7 (2002) d1926-d1940
3. Baselga J., Albanell J., Molina M.A., and Arribas J. Mechanism of action of trastuzumab and scientific update. Semin. Oncol. 28 (2001) 4-11
4. Fry D.W. Mechanism of action of erbB tyrosine kinase inhibitors. Exp. Cell Res. 284 (2003) 131-139
5. Neckers L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol. Med. 8 (2002) S55-S61
6. Hong R.L., Spohn W.H., and Hung M.C. Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu. Clin. Cancer Res. 5 (1999) 1884-1891
7. Xu W., Marcu M., Yuan X., Mimnaugh E., Patterson C., and Neckers L. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 12847-12852
8. Joe B., Vijaykumar M., and Lokesh B.R. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit. Rev. Food Sci. Nutr. 44 (2004) 97-111
9. Aggarwal B.B., Kumar A., and Bharti A.C. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 23 (2003) 363-398
10. Xu W., Yuan X., Xiang Z., Mimnaugh E., Marcu M., and Neckers L. Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. Nat. Struct. Mol. Biol. 12 (2005) 120-126
11. Xu W., Mimnaugh E., Rosser M.F., Nicchitta C., Marcu M., Yarden Y., and Neckers L. Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J. Biol. Chem. 276 (2001) 3702-3708
12. Zhou P., Fernandes N., Dodge I.L., Reddi A.L., Rao N., Safran H., DiPetrillo T.A., Wazer D.E., Band V., and Band H. ErbB2 degradation mediated by the co-chaperone protein CHIP. J. Biol. Chem. 278 (2003) 13829-13837
13. McDonough H., and Patterson C. CHIP: a link between the chaperone and proteasome systems. Cell Stress Chaperones 8 (2003) 303-308
14. Tikhomirov O., and Carpenter G. Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation. Cancer Res. 63 (2003) 39-43
15. Uy R., and Wold F. Posttranslational covalent modification of proteins. Science 198 (1977) 890-896
16. Tikhomirov O., and Carpenter G. Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin. J. Biol. Chem. 276 (2001) 33675-33680
17. Jana N.R., Dikshit P., Goswami A., and Nukina N. Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J. Biol. Chem. 279 (2004) 11680-11685
18. Liao W., and Chan L. Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cells. Biochem. J. 353 (2001) 493-501
19. d'Azzo A., Bongiovanni A., and Nastasi T. E3 ubiquitin ligases as regulators of membrane protein trafficking and degradation. Traffic 6 (2005) 429-441
20. Urbe S. Ubiquitin and endocytic protein sorting. Essays Biochem. 41 (2005) 81-98