Genetic susceptibility to essential hypertension: Insight from angiotensinogen

Hypertension

Volumn 49, Issue 3 PART 2 SUPPL., 2007, Pages 597-603

  Lalouel, Jean Marc ^a   Rohrwasser, Andreas ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensinogen; Essential hypertension; Genetics; High blood pressure; Renin

Indexed keywords

ANGIOTENSINOGEN; RENIN;

ALLELE; CONFERENCE PAPER; DISEASE MODEL; ESSENTIAL HYPERTENSION; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; HYPOTHESIS; KIDNEY CELL; KIDNEY COLLECTING TUBULE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE; MOLECULAR EVOLUTION; MOLECULAR MECHANICS; MOLECULAR MODEL; NEPHRON; NONHUMAN; PARACRINE SIGNALING; PATHOPHYSIOLOGY; POPULATION GENETICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANGIOTENSINOGEN; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTENSION; MICE; NEPHRONS; RATS; RENIN-ANGIOTENSIN SYSTEM;

EID: 33847058515     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000257145.20363.9c     Document Type: Conference Paper

References (78)

1. Guyton AC. Arterial Pressure and Hypertension. Philadelphia, PA: W.B. Saunders; 1980.
2. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell. 2001;104:545-556.
3. Lalouel JM, Rohrwasser A, Terreros D, Morgan T, Ward K. Angiotensinogen in essential hypertension: from genetics to nephrology. J Am Soc Nephrol. 2001;12:606-615.
4. Bianchi G. Genetic variations of tubular sodium reabsorption leading to "primary" hypertension: from gene polymorphism to clinical symptoms. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1536-R1549.
5. Siffert W. G protein polymorphisms in hypertension, atherosclerosis, and diabetes. Annu Rev Med. 2005;56:17-28.
6. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, Corvol P. Molecular basis of human hypertension: role of angiotensinogen. Cell. 1992;71:169 -180.
7. Hata A, Namikawa C, Sasaki M, Sato K, Nakamura T, Tamura K, Lalouel JM. Angiotensinogen as a risk factor for essential hypertension in Japan. J Clin Invest. 1994;93:1285-1287.
8. Ward K, Hata A, Jeunemaitre X, Helin C, Nelson L, Namikawa C, Farrington PF, Ogasawara M, Suzumori K, Tomoda S, Berrebi S, Sasaki M, Corvol P, Lifton RP, Lalouel JM. A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet. 1993;4:59-61.
9. Lalouel JM, Rohrwasser A. Power and replication in case-control studies. Am J Hypertens. 2002;15:201-205.
10. Kunz R, Kreutz R, Beige J, Distler A, Sharma AM. Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal. Hypertension. 1997;30:1331-1337.
11. Staessen JA, Kuznetsova T, Wang JG, Emelianov D, Vlietinck R, Fagard R. M235T angiotensinogen gene polymorphism and cardiovascular renal risk. J Hypertens. 1999;17:9-17.
12. Lalouel JM. From genetics to mechanism of disease liability. In: Rao DC, Province MA, eds. Genetic Dissection of Complex Traits. St Louis, MO: Academic Press; 2001:517-533.
13. Gordon DB. The role of renin substrate in hypertension. Hypertension. 1983;5:353-362.
14. Menard J, el Amrani AI, Savoie F, Bouhnik J. Angiotensinogen: an attractive and underrated participant in hypertension and inflammation [letter; comment]. Hypertension. 1991;18:705-707.
15. Gould AB, Green D. Kinetics of the human renin and human substrate reaction. Cardiovasc Res. 1971;5:86-89.
16. Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M, Cheng T, Ludwig EH, Sharma AM, Hata A, Jeunemaitre X, Lalouel JM. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest. 1997;99:1786-1797.
17. Gimenez-Roqueplo AP, Celerier J, Schmid G, Corvol P, Jeunemaitre X. Role of cysteine residues in human angiotensinogen. Cys232 is required for angiotensinogen-pro major basic protein complex formation. J Biol Chem. 1998;273:34480-34487.
18. Ishigami T, Tamura K, Fujita T, Kobayashi I, Hibi K, Kihara M, Toya Y, Ochiai H, Umemura S. Angiotensinogen gene polymorphism near transcription start site and blood pressure: role of a T-to-C transition at intron I. Hypertension. 1999;34:430-434.
19. Morgan T, Craven C, Nelson L, Lalouel JM, Ward K. Angiotensinogen T235 expression is elevated in decidual spiral arteries. J Clin Invest. 1997;100:1406-1415.
20. Ohkubo H, Kawakami H, Kakehi Y, Takumi T, Arai H, Yokota Y, Iwai M, Tanabe Y, Masu M, Hata J, Iwao H, Okamoto H, Yokoyama M, Nomura T, Katsuki M, Nakanishi S. Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes. Proc Natl Acad Sci U S A. 1990;87:5153-5157.
21. Kimura S, Mullins JJ, Bunnemann B, Metzger R, Hilgenfeldt U, Zimmermann F, Jacob H, Fuxe K, Ganten D, Kaling M. High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J. 1992;11:821-827.
22. Uehara S, Mino N, Tsuchida M, Nishikibe M, Fukamizu A, Murakami K, Ikemoto F Development of polyuria in Tsukuba hypertensive mice carrying human renin and angiotensinogen genes. Clin Exp Pharmacol Physiol. 1995;22(suppl 1):S12-S14.
23. Merrill DC, Thompson MW, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD. Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest. 1996;97:1047-1055.
24. Yang G, Merrill DC, Thompson MW, Robillard JE, Sigmund CD. Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem. 1994;269:32497-32502.
25. Smithies O, Kim HS. Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc Natl Acad Sci U S A. 1994;91:3612-3615.
26. Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, Smithies O. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A. 1995;92:2735-2739.
27. Hall J, Brands M. Intrarenal and circulating angiotensin II and renal function. In: Robertson J, Nicholls M, eds. The Renin-Angiotensin System. Vol 1. New York, NY: Gower Medical Publishing; 1993;26:21-26.43.
28. Navar LG, Imig JD, Zou L, Wang CT. Intrarenal production of angiotensin II. Semin Nephrol. 1997;17:412-422.
29. Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem. 1997;272:28142-28148.
30. Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD. Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics. 1999;1:3-9.
31. Navar LG, Harrison-Bernard LM, Wang CT, Cervenka L, Mitchell KD. Concentrations and actions of intraluminal angiotensin II. J Am Soc Nephrol. 1999;10(suppl 11):S189-S195.
32. Casarini DE, Boim MA, Stella RC, Krieger-Azzolini MH, Krieger JE, Schor N. Angiotensin I-converting enzyme activity in tubular fluid along the rat nephron. Am J Physiol. 1997;272:F405-F409.
33. Harrison-Bernard LM, Navar LG, Ho MM, Vinson GP, el-Dahr SS. Immunohistochemical localization of ANG II AT1 receptor in adult rat kidney using a monoclonal antibody. Am J Physiol. 1997;273:F170-F177.
34. Ingelfinger JR, Pratt RE, Ellison K, Dzau VJ. Sodium regulation of angiotensinogen mRNA expression in rat kidney cortex and medulla. J Clin Invest. 1986;78:1311-1315.
35. Seikaly MG, Arant BSJ, Seney FDJ. Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest. 1990;86:1352-1357.
36. Braam B, Mitchell KD, Fox J, Navar LG. Proximal tubular secretion of angiotensin II in rats. Am J Physiol. 1993;264:F891-F898.
37. Quan A, Baum M. Regulation of proximal tubule transport by angiotensin II. Semin Nephrol. 1997;17:423-430.
38. Wang E, Yayama K, Takano M, Okamoto H. Sexual dimorphism of urine angiotensinogen excretion in the rat. Jpn J Pharmacol. 1994;64:243-250.
39. Rohrwasser A, Morgan T, Dillon HF, Zhao L, Callaway CW, Hillas E, Zhang S, Cheng T, Inagami T, Ward K, Terreros DA, Lalouel JM. Elements of a paracrine tubular renin-angiotensin system along the entire nephron. Hypertension. 1999;34:1265-1274.
40. Kobori H, Harrison-Bernard LM, Navar LG. Enhancement of angiotensinogen expression in angiotensin II-dependent hypertension. Hypertension. 2001;37:1329-1335.
41. Kobori H, Harrison-Bernard LM, Navar LG. Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension. J Am Soc Nephrol. 2001;12:431-439.
42. Kobori H, Harrison-Bernard LM, Navar LG. Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production. Kidney Int. 2002;61:579-585.
43. Kobori H, Nishiyama A, Abe Y, Navar LG. Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet. Hypertension. 2003;41:592-597.
44. Moe OW, Alpern RJ, Henrich WL. The renal proximal tubule renin-angiotensin system. Semin Nephrol. 1993;13:552-557.
45. Chen M, Harris MP, Rose D, Smart A, He XR, Kretzler M, Briggs JP, Schnermann J. Renin and renin mRNA in proximal tubules of the rat kidney. J Clin Invest. 1994;94:237-243.
46. Leyssac PP. A micropuncture study of glomerular filtration and tubular reabsorption of endogenous renin in the rat. Renal Physiol Basel. 1978;1:181-188.
47. Nielsen AH, Hermann KL, Mazanti I, Poulsen K. Urinary excretion of inactive renin during blockade of the renal tubular protein reabsorption with lysine. J Hypertens. 1989;7:77-82.
48. Rohrwasser A, Ishigami T, Gociman B, Lantelme P, Morgan T, Cheng T, Hillas E, Zhang S, Ward K, Bloch-Faure M, Meneton P, Lalouel JM. Renin and kallikrein in connecting tubule of mouse. Kidney Int. 2003;64:2155-2162.
49. Celio MR, Inagami T. Renin in the human kidney. Immunohistochemical localization. Histochemistry. 1981;72:1-10.
50. Taugner R, Hackenthal E, Inagami T, Nobiling R, Poulsen K. Vascular and tubular renin in the kidneys of mice. Histochemistry. 1982;75:473-484.
51. Gilbert RE, Wu LL, Kelly DJ, Cox A, Wilkinson-Berka JL, Johnston CI, Cooper ME. Pathological expression of renin and angiotensin II in the renal tubule after subtotal nephrectomy. Implications for the pathogenesis of tubulointerstitial fibrosis. Am J Pathol. 1999;155:429-440.
52. Torres VE, Donovan KA, Scicli G, Holley KE, Thibodeau SN, Carretero OA, Inagami T, McAteer JA, Johnson CM. Synthesis of renin by tubulocystic epithelium in autosomal-dominant polycystic kidney disease. Kidney Int. 1992;42:364-373.
53. Prieto-Carrasquero MC, Harrison-Bernard LM, Kobori H, Ozawa Y, Hering-Smith KS, Hamm LL, Navar LG. Enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. Hypertension. 2004;44:223-229.
54. Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T, McMahon A, Hummler E, Rossier BC. Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest. 2003;112:554-565.
55. Meneton P, Loffing J, Warnock DG. Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule. Am J Physiol Renal Physiol. 2004;287:F593-F601.
56. Castrop H, Oppermann M, Weiss Y, Huang Y, Mizel D, Lu H, Germain S, Schweda F, Theilig F, Bachmann S, Briggs J, Kurtz A, Schnermann J. Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene. Physiol Genomics. 2006;25:277-285.
57. Siragy HM. Angiotensin II compartmentalization within the kidney: effects of salt diet and blood pressure alterations. Curr Opin Nephrol Hypertens. 2006;15:50-53.
58. Hall JE, Brands MW, Henegar JR. Angiotensin II and long-term arterial pressure regulation: the overriding dominance of the kidney. J Am Soc Nephrol. 1999;10(suppl 12):S258-S265.
59. Wang T, Giebisch G. Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. Am J Physiol. 1996;271:F143-F149.
60. Peti-Peterdi J, Warnock DG, Bell PD. Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors. J Am Soc Nephrol. 2002;13:1131-1135.
61. Komlosi P, Fuson AL, Fintha A, Peti-Peterdi J, Rosivall L, Warnock DG, Bell PD. Angiotensin I conversion to angiotensin II stimulates cortical collecting duct sodium transport. Hypertension. 2003;42:195-199.
62. Walker WG, Saito H, Whelton PK, Russell RP, Hermann JS. An association between the renin angiotensin system, blood pressure and potassium intake. Trans Am Clin Climatol Assoc. 1979;91:107-114.
63. Massiera F, Bloch-Faure M, Ceiler D, Murakami K, Fukamizu A, Gasc JM, Quignard-Boulange A, Negrel R, Ailhaud G, Seydoux J, Meneton P, Teboul M. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 2001;15:2727-2729.
64. Stec DE, Keen HL, Sigmund CD. Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase. Hypertension. 2002;39:629-633.
65. Kobori H, Nishiyama A, Harrison-Bernard LM, Navar LG. Urinary angiotensinogen as an indicator of intrarenal Angiotensin status in hypertension. Hypertension. 2003;41:42-49.
66. Lantelme P, Rohrwasser A, Gociman B, Hillas E, Cheng T, Petty G, Thomas J, Xiao S, Ishigami T, Herrmann T, Terreros DA, Ward K, Lalouel JM. Effects of dietary sodium and genetic background on angiotensinogen and renin in mouse. Hypertension. 2002;39:1007-1014.
67. Lantelme P, Rohrwasser A, Vincent M, Cheng T, Gardier S, Legedz L, Bricca G, Lalouel JM, Milon H. Significance of urinary angiotensinogen in essential hypertension as a function of plasma renin and aldosterone status. J Hypertens. 2005;23:785-792.
68. Neel JV. Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet. 1962;14:353-362.
69. Nakajima T, Wooding S, Sakagami T, Emi M, Tokunaga K, Tamiya G, Ishigami T, Umemura S, Munkhbat B, Jin F, Guan-Jun J, Hayasaka I, Ishida T, Saitou N, Pavelka K, Lalouel JM, Jorde LB, Inoue I. Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the world. Am J Hum Genet. 2004;74:898-916.
70. Jeunemaitre X, Inoue I, Williams C, Charru A, Tichet J, Powers M, Sharma AM, Gimenez-Roqueplo AP, Hata A, Corvol P, Lalouel JM. Haplotypes of angiotensinogen in essential hypertension. Am J Hum Genet. 1997;60:1448-1460.
71. Denton D. The Hunger for Salt. An Anthropological, Physiological, and Medical Analysis. Berlin, Germany: Springer Verlag; 1984.
72. Lalouel JM. Concentrations Locales D'affections Hereditaires Rares. Paris, France: L'expansion Scientific Francaise; 1970.
73. Kumar A, Li Y, Patil S, Jain S. A haplotype of the angiotensinogen gene is associated with hypertension in African Americans. Clin Exp Pharmacol Physiol. 2005;32:495-502.
74. Ferrari P, Bianchi G. Genetic mapping and tailored antihypertensive therapy. Cardiovasc Drugs Ther. 2000;14:387-395.
75. Cowley AW Jr. Genomics and homeostasis. Am J Physiol Regul Integr Comp Physiol. 2003;284:R611-R627.
76. Smithies O. Theodore Cooper Memorial Lecture. A mouse view of hypertension. Hypertension. 1997;30:1318-1324.
77. Kim HS, Lee G, John SW, Maeda N, Smithies O. Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proc Natl Acad Sci U S A. 2002;99:4602-4607.
78. Cowley AW Jr. The genetic dissection of essential hypertension. Nat Rev Genet. 2006;7:829-840.