Antinecrotic and antiapoptotic effects of hepatocyte growth factor on cholestatic hepatitis in a mouse model of bile-obstructive diseases

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 292, Issue 2, 2007, Pages

  Li, Zhaodong ^a   Mizuno, Shinya ^a   Nakamura, Toshikazu ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Cholestasis; Necrosis; Regeneration

Indexed keywords

CELL ADHESION MOLECULE; IMMUNOGLOBULIN G; MESSENGER RNA; PROTEIN ANTIBODY; PROTEIN BCL XL; RECOMBINANT SCATTER FACTOR; SCATTER FACTOR; SCATTER FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; BILE DUCT OBSTRUCTION; CELL COUNT; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CHEMOPROPHYLAXIS; CHOLESTASIS; CHOLESTATIC HEPATITIS; CONTROLLED STUDY; DISEASE COURSE; FEMALE; LIVER; LIVER CELL; LIVER DYSFUNCTION; LIVER NECROSIS; LIVER PARENCHYMA; LIVER PROTECTION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; TISSUE REPAIR; UPREGULATION;

ALANINE TRANSAMINASE; ANIMALS; ANTIBODIES; APOPTOSIS; BCL-X PROTEIN; BILIRUBIN; CASPASE 3; CHOLESTASIS, EXTRAHEPATIC; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; HEPATITIS, ANIMAL; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; INTERCELLULAR ADHESION MOLECULE-1; LIVER; LIVER REGENERATION; MICE; MICE, INBRED ICR; NECROSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MET; RECOMBINANT PROTEINS; TRANSAMINASES;

EID: 33847055836     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00292.2006     Document Type: Article

References (48)

1. Benz C, Angermuller S, Tox U, Kloters-Planchky P, Riedel HD, Sauer P, Stremmel W, Stiehl A. Effect of tauroursodeoxycholic acid on bileacid-induced apoptosis and cytolysis in rat hepatocytes. J Hepatol 28: 99-106, 1998.
2. Birchmeier C, Gherardi E. Developmental roles of HGF/SF and its receptor, c-Met tyrosine kinase. Trends Cell Biol 8: 404-410, 1998.
3. Bird MA, Lange PA, Schrum LW, Grisham JW, Rippe RA, Behrns KE. Cholestasis induces murine hepatocyte apoptosis and DNA synthesis with preservation of the immediate early gene response. Surgery 131: 556-563, 2002.
4. Canby A, Guicciardi ME, Higuchi H, Feldstein A, Bronk SF, Rydzewski R, Taniai M, Gores GJ. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest 112: 152-159, 2003.
5. Gujral JS, Farhood A, Jaeschke H. Oncotic necrosis and caspasedependent apoptosis during galactosamine-induced liver injury in rats. Toxicol Appl Pharmacol 190: 37-46, 2003.
6. Gujral JS, Liu J, Farhood A, Hinson JA, Jaeschke H. Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice. Am J Physiol Gastrointest Liver Physiol 286: G499-G507, 2004.
7. Gujral JS, Liu J, Farhood A, Jaeschke H. Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation. Hepatology 40: 998-1007, 2004.
8. Hofmann AF. Cholestatic liver disease: pathophysiology and therapeutic options. Liver 22, Suppl 2: 14-19, 2002.
9. Huh CC, Factor VM, Sanchez A, Uchida K, Conner EA, Thorgeirsson SS. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci USA 101: 4477-4482, 2004.
10. Ijiri R, Tanaka Y, Kato K, Misugi K, Ohama Y, Shinkai M, Nishi T, Aida N, Kondo F. Clinico-pathological study of a lilar nodule in the livers of long-term survivors with biliary atresia. Pathol Int 51: 16-19, 2001.
11. Ishiki Y, Ohnishi H, Muto Y, Matsumoto K, Nakamura T. Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and for potent anti-hepatitis action in vivo. Hepatology 16: 1227-1235, 1992.
12. Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia reperfusion injury. Gastroenterology 125: 1246-1257, 2003.
13. Jaeschke H. Cellular adhesion molecules: regulation and functional significance in the pathogenesis of liver diseases. Am J Physiol Gastrointest Liver Physiol 273: G602-G611, 1997.
14. Kosai K, Matsumoto K, Nagata S, Tsujimoto Y, Nakamura T. Abrogation of FAS-induced fulminant hepatic failure in mice by hepatocyte growth factor. Biochem Biophys Res Commun 127: 683-690, 1998.
15. Kosai K, Matsumoto K, Funakoshi H, Nakamura T. Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology 30: 151-159, 1999.
16. Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: a new experimental model for cholestasis in the rat. Br J Exp Pathol 65: 305-311, 1984.
17. Krahenbuhl S, Talos C, Lauterburg BH, Reichen J. Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats. Hepatology 22: 607-612, 1995.
18. Marucci L, Baroni GS, Benedetti A, Jezequel AM, Orlandi F. Cell proliferation following extrahepatic biliary obstruction. Evaluation by immunohistochemical methods. J Hepatol 17: 163-169, 1993.
19. Masunaga H, Fujise N, Shiota A, Ogawa H, Sato Y, Imai E, Yasuda H, Higashio K. Preventive effects of the deleted form of hepatocyte growth factor against liver injuries. Eur J Pharmacol 342: 267-279, 1998.
20. Matsuda Y, Matsumoto K, Tsuchida T, Nakamura T. Hepatocyte growth factor prevents liver cirrhosis caused by dimethylnitrosamine in rats. J Biochem (Tokyo) 118: 643-649, 1995.
21. Matsumoto K, Nakamura T. Emerging multipotent aspects of hepatocyte growth factor. J Biochem (Tokyo) 119: 591-600, 1996.
22. McKierman PJ, Baker AJ, Kelly AD. The frequency and outcome of biliary atresia in the UK and Ireland. Lancet 355: 25-29, 2000.
23. Miyoshi H, Rust C, Roberts PJ, Burgart LJ, Gores GJ. Hepatocyte apoptosis after bile duct ligation in mouse involves Fas. Gastroenterology 117: 669-677, 1999.
24. Mizoguchi Y, Tsutsui H, Miyajima K, Sakagami Y, Seki S, Kobayashi K, Yamamoto S, Morisawa S. The protective effects of prostaglandin E1 in an experimental massive hepatic cell necrosis model. Hepatology 7: 1184-1188, 1987.
25. Mizuno S, Matsumoto K, Kurosawa T, Mizuno-Horikawa Y, Nakamura T. Reciprocal balance of hepatocyte growth factor and transforming growth factor-beta1 in renal fibrosis in mice. Kidney Int 57: 937-948, 2000.
26. Mizuno S, Nakamura T. Prevention of neutrophil extravasation by HGF leads to attenuations of tubular apoptosis and renal dysfunction in mouse ischemic kidneys. Am J Pathol 166: 1895-1905, 2005.
27. Nakahira R, Mizuno S, Yoshimine T, Nakamura T. The loss of local HGF, an endogenous gastrophic factor, leads to mucosal injuries in the stomach of mice. Biochem Biophys Res Commun 341: 897-903, 2006.
28. Nakamura T, Nawa K, Ichihara A. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun 122: 1450-1459, 1984.
29. Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi A, Sugimura K, Shimizu S. Molecular cloning and expression of human hepatocyte growth factor. Nature 342: 440-443, 1989.
30. Nakamura T, Mizuno S, Matsumoto K, Sawa Y, Matsuda H, Nakamura T. Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. J Clin Invest 106: 1511-1519, 2000.
31. Napoli J, Prentice D, Niinami C, Bishop GA, Desmond P, McCaughan GW. Sequential increases in the intrahepatic expression of epidermal growth factor, fibroblast growth factor, and transforming growth factorbeta in a bile duct ligated rat model of cirrhosis. Hepatology 26: 624-633, 1997.
32. Oe S, Hiros T, Fujii H, Yasuchika K, Nishio T, Iimuro Y, Morimoto T, Nagao M, Yamaoka Y. Continuous intravenous infusion of deleted form of hepatocyte growth factor attenuates hepatic ischemia-reperfusion injury in rats. J Hepatol 34: 832-839, 2001.
33. Okano J, Shiota G, Kawasaki H. Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice. Hepatology 26: 1241-1249, 1997.
34. Patel T, Gorges GJ. Apoptosis and hepatobiliary disease. Hepatology 21:1725-1741, 1995.
35. Saito JM, Maher JJ. Bile duct ligation in rats induces biliary expression of chemokine-induced neutrophil chemoattractant. Gastroenterology 118: 1157-1168, 2000.
36. Sakamaki Y, Matsumoto K, Mizuno S, Miyoshi S, Matsuda H, Nakamura T. Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice. Am J Respir Cell Mol Biol 26: 525-533, 2002.
37. Singh S, Shackleton G, Ah-Sing E, Chakraborty J, Bailey ME. Antioxidant defenses in the bile duct-ligated rat. Gastroenterology 103: 1625-1629, 1992.
38. Takahashi M, Ota S, Hata Y, Mikami Y, Azuma N, Nakamura T, Terano A, Omata M. Hepatocyte growth factor as a key mitogen to modulate anti-ulcer action of prostaglandins in stomach. J Clin Invest 98: 2604-2611, 1996.
39. Takehara T, Nakamura T. Protective effect of hepatocyte growth factor on in vitro hepatitis in primary cultured hepatocytes. Biomed Res (Tokyo) 12: 335-338, 1991.
40. Takehara T, Tatsumi T, Suzuki T, Rucker EB, Hennighausen L, Jinushi M, Miyagi T, Kanazawa Y, Hayashi N. Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses. Gastroenterology 127: 1189-1197, 2004.
41. Trauner M, Meier PJ, Boyer JL. Molecular pathogenesis of cholestasis. N Engl J Med 339: 1217-1227, 1998.
42. Tsau YK, Chen CH, Chang MH, Teng RJ, Lu MY, Lee PI. Nephromegaly and elevated hepatocyte growth factor in children with biliary atresia. Am J Kidney Dis 29: 188-192, 1997.
43. Tsuboi S. Elevation of glutathione level in rat hepatocytes by hepatocyte growth factor via induction of gamma-glutamylcysteine synthetase. J Biochem (Tokyo) 126: 815-820, 1999.
44. Vejchapipat P, Theamboonlers A, Chaokhonchai R, Chongsrisawat V, Chittmittrapap S, Poovorawan Y. Serum hepatocyte growth factor and clinical outcome in biliary atresia. J Pediatr Surg 39: 1045-1049, 2004.
45. Wang H, Vohra BP, Zhang Y, Heuckeroth RO. Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice. Hepatology 42: 1099-1108, 2005.
46. Wang X, DeFrances MC, Dai Y, Pediaditakis P, Johnson C, Bell A, Michalopoulos GK, Zarnegar R. A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell 9: 411-421, 2002.
47. Yamano T, Hirai R, Hato S, Uemura T, Shimizu N. Delayed liver regeneration with negative regulation of hepatocyte growth factor and positive regulation of transforming growth factor-beta1 mRNA after portal branch ligation in biliary obstructed rats. Surgery 131: 163-171, 2002.
48. Yoshikawa A, Kaido T, Seto S, Yamaoka S, Sato M, Ishii T, Imamura M. Hepatocyte growth factor promotes liver regeneration with prompt improvement of hyperbilirubinemia in hepatectomized cholestatic rats. J Surg Res 78: 54-59, 1998.