Neuroprotection against ischemic brain injury conferred by a novel nitrate ester

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 20, 2002, Pages 2863-2866

  Reynolds, James N ^a   Bennett, Brian M ^a   Boegman, Roland J ^a   Jhamandas, Khem ^a   Ratz, Jodan D ^a   Zavorin, Sergei I ^a   Scutaru, Dan ^a   Dumitrascu, Adina ^a   Thatcher, Gregory R J ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCERYL TRINITRATE; GT 715; NITRIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; OXIDATION; RAT;

ANIMALS; BLOOD PRESSURE; BRAIN; BRAIN ISCHEMIA; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANYLATE CYCLASE; INFARCTION, MIDDLE CEREBRAL ARTERY; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NEUROPROTECTIVE AGENTS; NITRATES; NITROGLYCERIN; PROPANE; RATS; VASODILATOR AGENTS;

EID: 0037152463     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00631-5     Document Type: Article

References (31)

1. Lee J.M., Zipfel G.J., Choi D.W. Nature. 399(A7):1999.
2. Lipton S.A., Choi Y.B., Pan Z.H., Lei S.Z., Chen H.S., Sucher N.J., Loscalzo J., Singel D.J., Stamler J.S. Nature. 364:1993;626.
3. Brorson J.R., Schumacker P.T., Zhang H. J. Neurosci. 19:1999;147.
4. Chiueh C.C. Ann. N.Y. Acad. Sci. 890:1999;301.
5. Tenneti L., D'Emilia D.M., Lipton S.A. Neurosci. Lett. 236:1997;139.
6. Lipton S.A. Nitric Oxide. 453:2000.
7. Artz J.D., Toader V., Zavorin S.I., Bennett B.M., Thatcher G.R. J. Biochemistry. 40:2001;9256.
8. Bennett B.M., McDonald B.J., Nigam R., Simon W.C. Trends Pharmacol. Sci. 15:1994;245.
9. Thatcher G.R.J., Weldon H. Chem. Soc. Rev. 27:1998;331.
10. Zavorin S.I., Artz J.D., Dumitrascu A., Nicolescu A., Scutaru D., Smith S.V., Thatcher G.R. Org. Lett. 3:2001;1113.
11. Yang K., Artz J.D., Lock J., Sanchez C., Bennett B.M., Fraser A.B., Thatcher G.R.J. J. Chem. Soc., Perkin Trans. 1. 1996;1073.
12. Stewart D.H., Hayward L.D., Bennett B.M. Can. J. Phys. Pharmacol. 67:1989;1403.
13. Ignarro L.J., Buga G.M., Wood K.S., Byrns R.E., Chaudhuri G. Proc. Natl. Acad. Sci. U.S.A. 84:1987;9265.
14. Murad F., Waldman S., Molina C., Bennett B., Leitman D. Prog. Clin. Biol. Res. 249:1987;65.
15. Saavedra J.E., Shami P.J., Wang L.Y., Davies K.M., Booth M.N., Citro M.L., Keefer L.K. J. Med. Chem. 43:2000;261.
16. McGill A.D., Zhang W., Wittbrodt J., Wang J., Schlegel H.B., Wang P.G. Bioorg. Med. Chem. 8:2000;405.
17. Artz J.D., Thatcher G.R. J. Chem. Res. Toxicol. 11:1998;1608.
18. Lipton S.A., Singel D.J., Stamler J.S. Ann. N.Y. Acad. Sci. 738:1994;382.
19. Ramos-Zuniga R., Velazquez-Santana H., Mercado-Pimentel R., Cerda-Camacho F. Minim. Invasive Neurosurg. 41:1998;152.
20. Smith S., Dringenberg H.C., Bennett B.M., Thatcher G.R., Reynolds J.N. Neuroreport. 11:2000;3883.
21. Garthwaite G., Garthwaite J. Neuroscience. 26:1988;321.
22. Estevez A.G., Spear N., Thompson J.A., Cornwell T.L., Radi R., Barbeito L., Beckman J.S. J. Neurosci. 18:1998;3708.
23. Keller J.N., Hanni K.B., Mattson M.P., Markesbery W.R. Neuroreport. 9:1998;3731.
24. Barger S.W., Fiscus R.R., Ruth P., Hofmann F., Mattson M.P. J. Neurochem. 64:1995;2087.
25. Mattson M.P., Guo Z.H., Geiger J.D. J. Neurochem. 73:1999;532.
26. Lei S., Jackson M.F., Jia Z., Roder J., Bai D., Orser B.A., MacDonald J.F. Nat. Neurosci. 3:2000;559.
27. Denninger J.W., Marletta M.A. Biochim. Biophys. Acta. 1411:1999;334.
28. Gibb B.J., Garthwaite J. Eur. J. Neurosci. 13:2001;539.
29. Stout A.K., Woodward J. J. Neuropharmacology. 33:1994;1367.
30. Rubbo H., Radi R., Anselmi D., Kirk M., Barnes S., Butler J., Eiserich J.P., Freeman B.A. J. Biol. Chem. 275:2000;10812.
31. Nicolescu, A.; Toader, V.; Zavorin, S. I.; Turro, N. J.; Reynolds, J. N.; Thatcher, G. R. J. Chem. Res. Toxicol. 2002, 15, 985.