Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study

Archives of Gerontology and Geriatrics

Volumn 44, Issue SUPPL., 2007, Pages 193-198

  Gallucci, M ^a   Amici, G P ^a   Ongaro, F ^b   Gajo, G B ^d   De Angeli, S ^d   Forloni, G L ^e   Albani, D ^e   Prato, F ^e   Polito, L ^e   Zanardo, A ^c   Regini, C ^a  

^a ARGel   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c Clinical Chemistry Laboratory Regional Hospital Treviso   (Italy)

^d Treviso General Hospital   (Italy)

^e MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Comorbidity in elderly; Disability of elderly; lnterleukin 6; Mortality

Indexed keywords

CYTOKINE; INTERLEUKIN 6;

AGED; AGING; ARTICLE; BLOOD SAMPLING; COMORBIDITY; CYTOKINE PRODUCTION; DAILY LIFE ACTIVITY; DISABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GERONTOLOGICAL RESEARCH; HUMAN; IMMUNE SYSTEM; ITALY; LONGEVITY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; SCORING SYSTEM;

AGED; AGED, 80 AND OVER; DISABILITY EVALUATION; FEMALE; HEALTH STATUS; HUMANS; INTERLEUKIN-6; ITALY; MALE; MORTALITY;

EID: 33847018456     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.archger.2007.01.026     Document Type: Article

References (18)

1. Bethin K.E., Vogt S.K., and Muglia L.J. lnterleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation. Proc. Natl. Acad. Sci. USA 97 (2000) 9317-9322
2. Cohen H.J., Pieper C.F., Harris T., Rao K.M., and Currie M.S. The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J. Gerontol. A. Biol. Sci. Med. Sci. 52 (1997) M201-M208
3. Colinet B., Jacot W., Bertrand D., Lacombe S., Bozonnat M.C., Daures J.P., and Pujol J.L. A new simplified comorbidity score as a prognostic factor in non-small-cell lung cancer patients: description and comparison with the Charlson's index. Br. J. Cancer 93 (2005) 1098-1105
4. Di Bari M., Virgillo A., Matteuzzi D., Inzitari M., Mazzaglia G., Pozzi C., Geppetti P., Masotti G., Marchionni N., and Pint R. Predictive validity of measures of comorbidity in older community dwellers: the "Insufficienza Cardiaca negli Anziani Residenti a Dicomano Study". J. Am. Geriatr. Soc. 54 (2006) 210-216
5. Ershler W.B., and Keller E.T. Age-associated increased IL-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 51 (2000) 245-270
6. Ferrucci L., Harris T.B., Guralnik J.M., Tracy R.P., Corti M.C., Cohen H.J., Penninx B., Pahor M., Wallace R., and Havlik R.J. Serum IL-6 level and the development of disability in older persons. J. Am. Geriatr. Soc. 47 (1999) 639-646
7. In: Gallucci M. (Ed). Sulla longevità. Eredità culturali e nuove frontiere: il caso Treviso (2002), Edizioni Antilia, Treviso (in Italian)
8. Gallucci M. Lo studio "Treviso longeva": analisi preliminari sui dati campionari (2004), Edizioni Antilia, Treviso (in Italian)
9. Gallucci M., Ongaro F., Bresolin F., Bemardi U., Salvato C., Minello A., Amici G.P., Barasciutti E., Mazzuco S., Gajo G.B., De Angeli S., Zanardo A., Forloni G.L., Albani D., Pesaresi M., and Regini C. The Treviso Longeva (Trelong) Study: a biomedical, demographic, economic and social investigation on people 70 years and over in a typical town of North-East of Italy. Arch. Gerontol. Geriatr. 44 Suppl. 1 (2007) 173-192
10. Harris T.B., Ferrucci L., Tracy R.P., Corti M.C., Wacholder S., Ettinger, Heimovitz H., Cohen H.J., and Wallace R. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106 (1999) 506-512
11. Keller E.T., Wanagat J., and Ershler W.B. Molecular and cellular biology of interleukin-6 and its receptor. Front. Biosci. (1996) D340-D357
12. Lawton M., and Brody E. Assesment of older people: self maintaining and instrumental activities of daily living. Gerontologist 9 (1969) 176-186
13. Parmar M.K.B., and Machin D. Survival Analysis: A Practical Approach (1995), John Wiley and Sons, Chichester, England
14. Path G., Bomstein S.R., Gurniak M., Chrousos G.P., Scherbaum W.A., and Hauner H. Human breast adipocytes express interleukin-6 (IL-6) and its receptor system: increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function. J. Clin. Endocrinol. Metab. 86 (2001) 2281-2288
15. Perkins A.J., Kroenke K., Unutzer J., Katon W., Williams J.W., Hope C., and Callahan C.M. Common comorbidity scales were similar in their ability to predict health care costs and mortality. J. Clin. Epidemiol. 57 (2004) 1040-1048
16. Volpato S., Guralnik J.M., Ferrucci L., Balfour J., Chaves P., Fried L.P., and Harris T.B. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation 103 (2001) 947-953
17. WHO, (World Health Organization) (1998): International Classification of Diseases, 9th Revision, with Clinical Modifications (ICD-9-CM). ftp://ftp.cdc.gov/pub/Health_Statistics/NCHS/Publications/ICD-9.
18. Xing Z., Gauldie J., Cox G., Baumann H., Jordana M., Lei X.F., and Achong M.K. IL-6 is an antiinfiammatory cytokine required for controlling local or systemic acute inflammatory responses. J. Clin. Invest. 101 (1998) 311-320