메뉴 건너뛰기




Volumn 23, Issue 4, 2006, Pages 521-531

Adjuvant chemotherapy in elderly patients (≥75 yr) completely resected for colon cancer stage III compared to younger patients: Toxicity and prognosis

Author keywords

Adverse effects; Aged; Chemotherapy, adjuvant; Colonic neoplasms; Disease free survival; Fluorouracil

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

EID: 33847006971     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1385/MO:23:4:521     Document Type: Article
Times cited : (16)

References (32)
  • 1
    • 0033616484 scopus 로고    scopus 로고
    • Colorectal cancer
    • Midgley R, Kerr D. Colorectal cancer. Lancet 1999; 353:391-399.
    • (1999) Lancet , vol.353 , pp. 391-399
    • Midgley, R.1    Kerr, D.2
  • 2
    • 0028873376 scopus 로고
    • A national population-based study of incidence of colorectal cancer and age. Implications for screening in older Americans
    • Cooper GS, Yuan Z, Landefeld CS, Johanson JF, Rimm AA. A national population-based study of incidence of colorectal cancer and age. Implications for screening in older Americans. Cancer 1995; 75:775-781.
    • (1995) Cancer , vol.75 , pp. 775-781
    • Cooper, G.S.1    Yuan, Z.2    Landefeld, C.S.3    Johanson, J.F.4    Rimm, A.A.5
  • 3
    • 0025060806 scopus 로고
    • Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma
    • Moertel CG, et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 1990; 322:352-358.
    • (1990) N Engl J Med , vol.322 , pp. 352-358
    • Moertel, C.G.1
  • 4
    • 0024397951 scopus 로고
    • Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo Clinic
    • Laurie JA, et al. Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo Clinic. J Clin Oncol 1989; 7:1447-1456.
    • (1989) J Clin Oncol , vol.7 , pp. 1447-1456
    • Laurie, J.A.1
  • 5
    • 0032949446 scopus 로고    scopus 로고
    • Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
    • Mamounas E, et al. Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04). J Clin Oncol 1999; 17:1349-1355.
    • (1999) J Clin Oncol , vol.17 , pp. 1349-1355
    • Mamounas, E.1
  • 6
    • 0031982505 scopus 로고    scopus 로고
    • Prospectively randomized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer
    • O'Connell MJ, et al. Prospectively randomized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer. J Clin Oncol 1998; 16:295-300.
    • (1998) J Clin Oncol , vol.16 , pp. 295-300
    • O'Connell, M.J.1
  • 7
    • 0028274802 scopus 로고
    • Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer
    • Francini G, et al. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology 1994; 106:899-906.
    • (1994) Gastroenterology , vol.106 , pp. 899-906
    • Francini, G.1
  • 8
    • 0029644482 scopus 로고
    • Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators
    • Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators. Lancet 1995; 345:939-944.
    • (1995) Lancet , vol.345 , pp. 939-944
  • 9
    • 0032950293 scopus 로고    scopus 로고
    • Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer. International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT B2) Investigators
    • Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer. International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT B2) Investigators. J Clin Oncol 1999; 17:1356-1363.
    • (1999) J Clin Oncol , vol.17 , pp. 1356-1363
  • 10
    • 0035846320 scopus 로고    scopus 로고
    • A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients
    • Sargent DJ, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 2001; 345:1091-1097.
    • (2001) N Engl J Med , vol.345 , pp. 1091-1097
    • Sargent, D.J.1
  • 11
    • 84944371744 scopus 로고    scopus 로고
    • NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA 1990; 264:1444-1450.
    • NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA 1990; 264:1444-1450.
  • 12
    • 0035815928 scopus 로고    scopus 로고
    • Age and adjuvant chemotherapy use after surgery for stage III colon cancer
    • Schrag D, Cramer LD, Bach PB, Begg CB. Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst 2001; 93:850-857.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 850-857
    • Schrag, D.1    Cramer, L.D.2    Bach, P.B.3    Begg, C.B.4
  • 13
    • 20044370090 scopus 로고    scopus 로고
    • Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity
    • Lemmens VE, et al. Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity. Ann Oncol 2005; 16:767-772.
    • (2005) Ann Oncol , vol.16 , pp. 767-772
    • Lemmens, V.E.1
  • 14
    • 0035715386 scopus 로고    scopus 로고
    • Variations in the use of adjuvant chemotherapy for node-positive colon cancer in the elderly: A population-based study
    • Sundararajan V, Grann VR, Jacobson JS, Ahsan H, Neugut AI. Variations in the use of adjuvant chemotherapy for node-positive colon cancer in the elderly: a population-based study. Cancer J 2001; 7:213-218.
    • (2001) Cancer J , vol.7 , pp. 213-218
    • Sundararajan, V.1    Grann, V.R.2    Jacobson, J.S.3    Ahsan, H.4    Neugut, A.I.5
  • 16
  • 17
    • 0032729240 scopus 로고    scopus 로고
    • Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: Results from National Surgical Adjuvant Breast and Bowel Project C-04
    • Wolmark N, et al. Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol 1999; 17:3553-3559.
    • (1999) J Clin Oncol , vol.17 , pp. 3553-3559
    • Wolmark, N.1
  • 18
    • 0027436244 scopus 로고
    • The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: Results from National Surgical Adjuvant Breast and Bowel Project protocol C-03
    • Wolmark N, et al. The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. J Clin Oncol 1993; 11:1879-1887.
    • (1993) J Clin Oncol , vol.11 , pp. 1879-1887
    • Wolmark, N.1
  • 19
    • 0042887580 scopus 로고    scopus 로고
    • Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer: Results of a randomized trial
    • Andre T, et al. Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer: results of a randomized trial. J Clin Oncol 2003; 21:2896-2903.
    • (2003) J Clin Oncol , vol.21 , pp. 2896-2903
    • Andre, T.1
  • 20
    • 0036534110 scopus 로고    scopus 로고
    • Efficacy and toxicity of adjuvant chemotherapy in elderly patients with colon carcinoma: A 10-year experience of the Geisinger Medical Center
    • Fata F, et al. Efficacy and toxicity of adjuvant chemotherapy in elderly patients with colon carcinoma: a 10-year experience of the Geisinger Medical Center. Cancer 2002; 94:1931-1938.
    • (2002) Cancer , vol.94 , pp. 1931-1938
    • Fata, F.1
  • 21
    • 0034690610 scopus 로고    scopus 로고
    • Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer
    • Elsaleh H, et al. Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer. Lancet 2000; 355:1745-1750.
    • (2000) Lancet , vol.355 , pp. 1745-1750
    • Elsaleh, H.1
  • 22
    • 0028926064 scopus 로고
    • Adjuvant treatment of colorectal cancer in the elderly
    • Aschele C, et al. Adjuvant treatment of colorectal cancer in the elderly. Cancer Control 1995; 2:36-38.
    • (1995) Cancer Control , vol.2 , pp. 36-38
    • Aschele, C.1
  • 23
    • 0032792959 scopus 로고    scopus 로고
    • Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
    • Popescu RA, Norman A, Ross PJ, Parikh B, Cunningham D. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 1999; 17:2412-2418.
    • (1999) J Clin Oncol , vol.17 , pp. 2412-2418
    • Popescu, R.A.1    Norman, A.2    Ross, P.J.3    Parikh, B.4    Cunningham, D.5
  • 24
    • 2342419285 scopus 로고    scopus 로고
    • Weekly 5-fluorouracil and leucovorin: Achieving lower toxicity with higher dose-intensity in adjuvant chemotherapy after colorectal cancer resection
    • Patel K, et al. Weekly 5-fluorouracil and leucovorin: achieving lower toxicity with higher dose-intensity in adjuvant chemotherapy after colorectal cancer resection. Ann Oncol 2004; 15:568-573.
    • (2004) Ann Oncol , vol.15 , pp. 568-573
    • Patel, K.1
  • 25
    • 0033803210 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with 5-fluorouracil, L-folinic acid and levamisole for patients with colorectal cancer: Non-randomised comparison of weekly versus four-weekly schedules-less pain, same gain. QUASAR Colorectal Cancer Study Group
    • Kerr DJ, Gray R, McConkey C, Barnwell J: Adjuvant chemotherapy with 5-fluorouracil, L-folinic acid and levamisole for patients with colorectal cancer: non-randomised comparison of weekly versus four-weekly schedules-less pain, same gain. QUASAR Colorectal Cancer Study Group. Ann Oncol 2000; 11:947-955.
    • (2000) Ann Oncol , vol.11 , pp. 947-955
    • Kerr, D.J.1    Gray, R.2    McConkey, C.3    Barnwell, J.4
  • 26
    • 0034611854 scopus 로고    scopus 로고
    • Comparison of flourouracil with additional levamisole, higher-dose folinic acid, or both, as adjuvant chemotherapy for colorectal cancer: A randomised trial. QUASAR Collaborative Group
    • Comparison of flourouracil with additional levamisole, higher-dose folinic acid, or both, as adjuvant chemotherapy for colorectal cancer: a randomised trial. QUASAR Collaborative Group. Lancet 2000; 355:1588-1596.
    • (2000) Lancet , vol.355 , pp. 1588-1596
  • 27
    • 0037322806 scopus 로고    scopus 로고
    • Severe toxicity related to the 5-fluorouracil/leucovorin combination (the Mayo Clinic regimen): A prospective study in colorectal cancer patients
    • Tsalic M, Bar-Sela G, Beny A, Visel B, Haim N. Severe toxicity related to the 5-fluorouracil/leucovorin combination (the Mayo Clinic regimen): a prospective study in colorectal cancer patients. Am J Clin Oncol 2003; 26:103-106.
    • (2003) Am J Clin Oncol , vol.26 , pp. 103-106
    • Tsalic, M.1    Bar-Sela, G.2    Beny, A.3    Visel, B.4    Haim, N.5
  • 28
    • 0036789418 scopus 로고    scopus 로고
    • Effectiveness of adjuvant fluorouracil in clinical practice: A population-based cohort study of elderly patients with stage III colon cancer
    • Iwashyna TJ, Lamont EB. Effectiveness of adjuvant fluorouracil in clinical practice: a population-based cohort study of elderly patients with stage III colon cancer. J Clin Oncol 2002; 20:3992-3998.
    • (2002) J Clin Oncol , vol.20 , pp. 3992-3998
    • Iwashyna, T.J.1    Lamont, E.B.2
  • 29
    • 0037022820 scopus 로고    scopus 로고
    • Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer
    • Sundararajan V, et al. Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer. Ann Intern Med 2002; 136:349-357.
    • (2002) Ann Intern Med , vol.136 , pp. 349-357
    • Sundararajan, V.1
  • 30
    • 0020040563 scopus 로고
    • Cancer patient accessions into clinical trials: A pilot investigation into some patient and physician determinants of entry
    • McCusker J, Wax A, Bennett JM. Cancer patient accessions into clinical trials: a pilot investigation into some patient and physician determinants of entry. Am J Clin Oncol 1982; 5:227-236.
    • (1982) Am J Clin Oncol , vol.5 , pp. 227-236
    • McCusker, J.1    Wax, A.2    Bennett, J.M.3
  • 31
    • 0021128898 scopus 로고
    • Informed consent for investigational chemotherapy: Patients' and physicians' perceptions
    • Penman DT, et al. Informed consent for investigational chemotherapy: patients' and physicians' perceptions. J Clin Oncol 1984; 2:849-855.
    • (1984) J Clin Oncol , vol.2 , pp. 849-855
    • Penman, D.T.1
  • 32
    • 2642572647 scopus 로고    scopus 로고
    • Aging biology and geriatric clinical pharmacology
    • McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev 2004; 56:163-184.
    • (2004) Pharmacol Rev , vol.56 , pp. 163-184
    • McLean, A.J.1    Le Couteur, D.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.