Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression

Molecular Cancer

Volumn 6, Issue , 2007, Pages

  Wang, Zhong ^a   Lecane, Philip S ^a   Thiemann, Patricia ^a   Fan, Qing ^a   Cortez, Cecilia ^a   Ma, Xuan ^a   Tonev, Danielle ^a   Miles, Dale ^a   Naumovski, Louie ^a   Miller, Richard A ^a   Magda, Darren ^a   Cho, Dong Gyu ^b   Sessler, Jonathan L ^b   Pike, Brian L ^c   Yeligar, Samantha M ^c   Karaman, Mazen W ^c   Hacia, Joseph G ^c  

^a PHARMACYCLICS INC   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BROXURIDINE; CISPLATIN; MESSENGER RNA; PCI 2012; PCI 2022; PCI 2042; PCI 2050; PORPHYRIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; SAPPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ALGORITHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ACTIVATION; CELL ADHESION; CELL CYCLE S PHASE; CELL DEATH; CELL PROLIFERATION; CELL TRANSPORT; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERANCE; FEMALE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION AND TRANSLATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; KIDNEY; LUNG CANCER; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROSTATE CANCER; RNA PROCESSING; SCREENING TEST; SINGLE DRUG DOSE; TRANSCRIPTION REGULATION; TUMOR LOCALIZATION; TUMOR MODEL; TUMOR XENOGRAFT;

CELL LINE, TUMOR; CELL PROLIFERATION; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR STRUCTURE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PORPHYRINS; REACTIVE OXYGEN SPECIES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 33847004356     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-6-9     Document Type: Article

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