Connexin 43 mediates endothelium-derived hyperpolarizing factor-induced vasodilatation in subcutaneous resistance arteries from healthy pregnant women

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 2, 2007, Pages

  Lang, Ninian N ^a   Luksha, Leonid ^b   Newby, David E ^a   Kublickiene, Karolina ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bradykinin; Connexin mimetic peptides; Gap junctions; Microcirculation

Indexed keywords

BRADYKININ; CONNEXIN 43; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; INDOMETACIN; N(G) NITROARGININE METHYL ESTER;

ADULT; ARTICLE; BIOPSY; CESAREAN SECTION; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MYOGRAPHY; NORMAL HUMAN; PREGNANT WOMAN; PRIORITY JOURNAL; RESISTANCE BLOOD VESSEL; SEQUENCE HOMOLOGY; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ADULT; ARTERIES; BIOLOGICAL FACTORS; BRADYKININ; CONNEXIN 43; CONNEXINS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GAP JUNCTIONS; HUMANS; INDOMETHACIN; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PEPTIDES; PREGNANCY; SUBCUTANEOUS FAT; VASODILATION; VASODILATOR AGENTS;

EID: 33846987217     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00797.2006     Document Type: Article

References (31)

1. Berman RS, Martin PE, Evans WH, Griffith TM. Relative contributions of NO and gap junctional communication to endothelium-dependent relaxations of rabbit resistance arteries vary with vessel size. Microvasc Res 63: 115-128, 2002.
2. Busse R, Edwards G, Feletou M, Fleming I, Vanhoutte PM, Weston AH. EDHF: bringing the concepts together. Trends Pharmacol Sci 23: 374-380, 2002.
3. Buus NH, Simonsen U, Pilegaard HK, Mulvany MJ. Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries. Br J Pharmacol 129: 184-192, 2000.
4. 2 in NO-independent relaxations of rabbit arteries. Proc Natl Acad Sci USA 100: 15212-15217, 2003.
5. Chaytor AT, Martin PE, Evans WH, Randall MD, Griffith TM. The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication. J Physiol 520: 539-550, 1999.
6. Christensen KL, Mulvany MJ. Vasodilatation, not hypotension, improves resistance vessel design during treatment of essential hypertension: a literature survey. J Hypertens 19: 1001-1006, 2001.
7. Coats P, Johnston F, MacDonald J, McMurray JJ, Hillier C. Endothelium-derived hyperpolarizing factor : identification and mechanisms of action in human subcutaneous resistance arteries. Circulation 103: 1702-1708, 2001.
8. Dantas MF, Urban M, Spray D, Catelli De Carvalho MH, Passaglia RD. Increased acetylcholine-induced vasodilation in pregnant rats: a role for gap junctional communication. Hypertension 34: 937-942, 1999.
9. De Wit C, Roos F, Bolz SS, Pohl U. Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion. Physiol Genomics 13: 169-177, 2003.
10. Feletou M, Vanhoutte PM. EDHF: new therapeutic targets? Pharmacol Res 49: 565-580, 2004.
11. Gillham JC, Kenny LC, Baker PN. An overview of endothelium-derived hyperpolarising factor (EDHF) in normal and compromised pregnancies. Eur J Obstet Gynecol Reprod Biol 109: 2-7, 2003.
12. Griffith TM. Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis? Br J Pharmacol 141: 881-903, 2004.
13. Katz SD, Krum H. Acetylcholine-mediated vasodilation in the forearm circulation of patients with heart failure: indirect evidence for the role of endothelium-derived hyperpolarizing factor. Am J Cardiol 87: 1089-1092, 2001.
14. Kenny LC, Baker PN, Kendall DA, Randall MD, Dunn WR. Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and pre-eclampsia. Clin Sci (Lond) 103: 67-73, 2002.
15. Li WE, Ochalski PA, Hertzberg EL, Nagy JI. Immunorecognition, ultrastructure and phosphorylation status of astrocytic gap junctions and connexin43 in rat brain after cerebral focal ischaemia. Eur J Neurosci 10: 2444-2463, 1998.
16. Liu MY, Hattori Y, Sato A, Ichikawa R, Zhang XH, Sakuma I. Ovariectomy attenuates hyperpolarization and relaxation mediated by endothelium-derived hyperpolarizing factor in female rat mesenteric artery: a concomitant decrease in connexin-43 expression. J Cardiovasc Pharmacol 40: 938-948, 2002.
17. Luksha L, Nisell H, Kublickiene K. The mechanism of EDHF-mediated responses in subcutaneous small arteries from healthy pregnant women. Am J Physiol Regul Integr Comp Physiol 286: R1102-R1109, 2004.
18. Malmsjo M, Bergdahl A, Zhao XH, Sun XY, Hedner T, Edvinsson L, Erlinge D. Enhanced acetylcholine and P2Y-receptor stimulated vascular EDHF-dilatation in congestive heart failure. Cardiovasc Res 43: 200-209, 1999.
19. Matchkov VV, Rahman A, Bakker LM, Griffith TM, Nilsson H, Aalkjaer C. Analysis of effects of connexin-mimetic peptides in rat mesenteric small arteries. Am J Physiol Heart Circ Physiol 291: H357-H367, 2006.
20. Matchkov VV, Rahman A, Peng H, Nilsson H, Aalkjaer C. Junctional and nonjunctional effects of heptanol and glycyrrhetinic acid derivates in rat mesenteric small arteries. Br J Pharmacol 142: 961-972, 2004.
21. McIntyre CA, Buckley CH, Jones GC, Sandeep TC, Andrews RC, Elliott AI, Gray GA, Williams BC, McKnight JA, Walker BR, Hadoke PW. Endothelium-derived hyperpolarizing factor and potassium use different mechanisms to induce relaxation of human subcutaneous resistance arteries. Br J Pharmacol 133: 902-908, 2001.
22. Mulvany MJ, Halpern W. Mechanical properties of vascular smooth muscle cells in situ. Nature 260: 617-619, 1976.
23. Nakamura K, Inai T, Nakamura K, Shibata Y. Distribution of gap junction protein connexin 37 in smooth muscle cells of the rat trachea and pulmonary artery. Arch Histol Cytol 62: 27-37, 1999.
24. Nakashima M, Mombouli JV, Taylor AA, Vanhoutte PM. Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries. J Clin Invest 92: 2867-2871, 1993.
25. Ohlmann P, Martinez MC, Schneider F, Stoclet JC, Andriantsitohaina R. Characterization of endothelium-derived relaxing factors released by bradykinin in human resistance arteries. Br J Pharmacol 121: 657-664, 1997.
26. Rummery NM, Hill CE. Vascular gap junctions and implications for hypertension. Clin Exp Pharmacol Physiol 31: 659-667, 2004.
27. Sandow SL. Factors, fiction and endothelium-derived hyperpolarizing factor. Clin Exp Pharmacol Physiol 31: 563-570, 2004.
28. Sandow SL, Tare M, Coleman HA, Hill CE, Parkington HC. Involvement of myoendothelial gap junctions in the actions of endothelium-derived hyperpolarizing factor. Circ Res 90: 1108-1113, 2002.
29. Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ, Ahluwalia A. Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation 111: 796-803, 2005.
30. Urakami-Harasawa L, Shimokawa H, Nakashima M, Egashira K, Takeshita A. Importance of endothelium-derived hyperpolarizing factor in human arteries. J Clin Invest 100: 2793-2799, 1997.
31. Wallerstedt SM, Bodelsson M. Endothelium-dependent relaxation by substance P in human isolated omental arteries and veins: relative contribution of prostanoids, nitric oxide and hyperpolarization. Br J Pharmacol 120: 25-30, 1997.