The autonomic nervous system at high altitude

Clinical Autonomic Research

Volumn 17, Issue 1, 2007, Pages 13-19

  Hainsworth, Roger ^a   Drinkhill, Mark J ^a   Rivera Chira, Maria ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UPCH   (Peru)

Author keywords

Altitude; Autonomic nervous system; Baroreceptors; Chemoreceptors; Hypoxia; Mountain sickness; Polycythemia; Respiration

Indexed keywords

ALTITUDE; ALTITUDE DISEASE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; BLOOD VISCOSITY; BLOOD VOLUME; BRAIN CIRCULATION; BRAIN PERFUSION; CHEMORECEPTOR; ERYTHROPOIESIS; EXERCISE; HEART RATE; HEART RATE VARIABILITY; HEART RIGHT VENTRICLE FAILURE; HEART STROKE VOLUME; HUMAN; HYPOXIA; LUNG ARTERY PRESSURE; LUNG FUNCTION; LUNG VASOCONSTRICTION; LUNG VENTILATION; NERVE CONDUCTION; NONHUMAN; PRESSORECEPTOR REFLEX; PULMONARY HYPERTENSION; REVIEW; SYMPATHETIC NERVE; SYMPATHETIC TONE; VASOCONSTRICTION;

ADAPTATION, PHYSIOLOGICAL; ALTITUDE; ALTITUDE SICKNESS; ANIMALS; AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR PHYSIOLOGY; HUMANS; TRAVEL;

EID: 33846981903     PISSN: 09599851     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10286-006-0395-7     Document Type: Review

References (72)

1. Appenzeller O, Minko T, Qualls T, et al. (2006) Gene expression, autonomic function and chronic hypoxia: a lesson from the Andes. Clin Auton Res 16:217-222
2. Azevedo ER, Newton GE, Floras JS, Parker JD (2000) Reducing cardiac filling pressure lowers norepinephrine spillover in patients with chronic heart failure. Circulation 101:2053-2059
3. Bainton CR, Carcelen A, Severinghaus JW (1964) Carotid chemoreceptor insensitivity in Andean natives. J Physiol 177:30-31
4. Beall CM (2003) High altitude adaptations. Lancet 362:S14-S15
5. Bernadi L, Passino C, Spadacini G, Calciali A, Robers R, Greene R, Martignani E, Anand I, Appenzeller O (1998) Cardiovascular autonomic modulation and activity of carotid baroreceptors at altitude. Clin Sci 95:565-573
6. Bernardi L, Roach RC, Keyl C, et al. (2003) Ventilation, autonomic function, sleep and erythropoietin. Chronic mountain sickness of Andean natives. Adv Exp Med Biol 543:161-175
7. Blaber AP, Hartley T, Pretorius PJ (2003) Effect of acute exposure to 3,660 m altitude on orthostatic responses and tolerance. J Appl Physiol 95:591-601
8. Boushel R, Calbet JA, Radegran G, Sondergaard H, Wagner PD, Saltin B (2001) Parasympathetic neural activity accounts for the lowering of exercise heart rate at high altitude. Circulation 104:785-791
9. Brown TE, Beightol LA, Koh J, Eckberg DL (1993) Important influence of respiration on human R-R interval power spectra is largely ignored. J Appl Physiol 75:2310-2317
10. Calbet JA (2003) Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans. J Physiol 551:379-386
11. Clar C, Dorrington KL, Fatemian M, Robbins PA (2001) Effects of 8 h of isocapnic hypoxia with and without muscarinic blockade on ventilation and heart rate in humans. Exp Physiol 86:529-538
12. Claydon VE, Norcliffe LJ, Moore JP, et al. (2004) Orthostatic tolerance and blood volumes in Andean high altitude dwellers. Exp Physiol 89:565-571
13. Claydon VE, Gulli G, Slessarev M, Huppert TJ, Assefa T, Gebru S, Appenzeller O, Hainsworth R (2005) Blood and plasma volumes in Ethiopian high altitude dwellers. Clin Auton Res 15:325
14. Claydon VE, Norcliffe LJ, Moore JP, et al. (2005) Cardiovascular responses to orthostatic stress in healthy altitude dwellers, and altitude residents with chronic mountain sickness. Exp Physiol 90:103-110
15. Cooper VL, Pearson SB, Bowker CM, Elliott MW, Hainsworth R (2005) Interaction of chemoreceptor and baroreceptor reflexes by hypoxia and hyperventilation. J Physiol 568:677-687
16. Cornolo J, Mollard P, Brugniaux JV, Robach P, Richalet JP (2004) Autonomic control of the cardiovascular system during acclimatization to high altitude:effects of sildenafil. J Appl Physiol 97:935-940
17. Duplain H, Vollenweider L, Delabays A, Nicod P, Bartsch P, Scherrer U (1999) Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation 99:1713-1718
18. Esler M (2000) The sympathetic system and hypertension. Am J Hypert 13:99S-105S
19. Fischetti F, Fabris B, Zaccaria M, Biagi A, Calci M, Candido R, Bortoletto M, Caretta R (2000) Effects of prolonged high-altitude exposure on peripheral adrenergic receptors in young healthy volunteers. Eur J Appl Physiol 82:439-445
20. Gamboa A, Gamboa JL, Holmes C, et al. (2006) Plasma catecholamines and blood volumes in native Andeans during hypoxia and normoxia. Clin Auton Res 16:40-45
21. Gamboa A, León-Velarde F, Rivera-Ch M, et al. (2003) Acute and sustained ventilatory responses to hypoxia in high-altitude natives living at sea level. J Appl Physiol 94:1255-1262
22. Gavras I, Manolis AJ, Gavras H (2001) The alpha2 -adrenergic receptors in hypertension and heart failure: experimental and clinical studies. J Hypert 19:2115-2124
23. Grollman A (1930) Physiological variations of the cardiac output of man. VII. The effect of high altitude on the cardiac output and its related functions: an account of experiments conducted on the summit of Pikes Peak, Colarado. Am J Physiol 93:19-40
24. Groves BM, Reeves JT, Sutton JR, Wagner PD, Cymerman A, Malconian MK, Rock PB, Young PM, Houston CS (1987) Operation Everest II: elevated high-altitude pulmonary resistance unresponsive to oxygen. J Appl Physiol 63:521-530
25. Halliwill JR, Minson CT (2002) Effect of hypoxia on arterial baroreflex control of heart rate and muscle sympathetic nerve activity in humans. J Appl Physiol 93:857-864
26. Halliwill JR, Minson CT (2005) Cardiovagal regulation during combined hypoxic and orthostatic stress: fainters vs. nonfainters. J Appl Physiol 98:1050-1056
27. Hansen J, Sander M (2003) Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia. J Physiol 546:921-929
28. Heistad DD, Abboud FM (1980) Circulatory adjustments to hypoxia. Circulation 61:463-470
29. Johnson TS, Rock PB, Young JB, Fulco CS, Trad LA (1988) Hemodynamic and sympathoadrenal responses to altitude in humans: effect of dexamethasone. Aviation Space Environ Med 59:208-12
30. Kacimi R, Richalet JP, Corsin A, Abousahl I, Crozatier B (1992) Hypoxia-induced downregulation of beta-adrenergic receptors in rat heart. J Appl Physiol 73:1377-1382
31. Kacimi R, Richalet JP, Crozatier B (1993) Hypoxia-induced differential modulation of adenosinergic and muscarinic receptors in rat heart. J Appl Physiol 75:1123-1128
32. Kanai M, Nishihara F, Shiga T, Shimada H, Saito S (2001) Alterations in autonomic nervous control of heart rate among tourists at 2700 and 3700 m above sea level. Wilderness Environ Med 12:8-12
33. Keyl C, Schneider A, Gamboa A, et al. (2003) Autonomic cardiovascular function in high-altitude Andean natives with chronic mountain sickness. J Appl Physiol 94:213-219
34. Kontos HA, Levasseur JE, Richardson DW, Mauck HP Jr, Patterson JL Jr (1967) Comparative circulatory responses to systemic hypoxia in man and in unanesthetized dog. J Appl Physiol 23:381-386
35. Leon-Velarde F, Bourin MC, Germack R, Mohammadi K, Crozatier B, Richalet JP (2001) Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion. Am J Physiol 280:R274-R281
36. León-Velarde F, Gamboa A, Rivera-Ch M, Palacios JA, Robbins PA (2003) Peripheral chemoreflex function in high-altitude natives and patients with chronic mountain sickness. J Appl Physiol 94:1269-1278
37. León-Velarde F, McCullough RG, Reeves JT, et al. (2003) Proposal for scoring severity in chronic mountain sickness (CMS). Background and conclusions of the CMS Working Group. Adv Med Biol 543:339-354
38. McMahon NC, Drinkhill MJ, Myers DS, Hainsworth R (2000) Reflex responses from the main pulmonary artery and bifurcation in anaesthetised dogs. Exp Physiol 85:411-420
39. Marshall JM (1994) Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev 74:543-594
40. Mazzeo RS, Bender PR, Brooks GA, et al. (1991) Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. Am J Physiol 261:E419-E424
41. Mazzeo RS, Child A, Butterfield GE, et al. (1998) Catecholamine response during 12 days of high-altitude exposure (4,300 m) in women. J Appl Physiol 84:1151-1157
42. Monge MC (1925) Sobre un caso de enfermedad de Váquez. Comunicación presentada a la Academia Nacional de Medicina. Lima 1-6
43. Monge CC, León-Velarde F (1991) Physiological adaptation to high altitude: oxygen transport in mammals and birds. Physiol Rev 71:135-172
44. Monge CC, Whittembury J (1982) Chronic mountain sickness and the physiopathology of hypoxemic polycythemia. In: Sutton JR, Jones NL, Houston CS (eds) Hypoxia: man at altitude. Thieme-Stratton, New York, pp 51-56
45. Moore JP, Claydon VE, Norcliffe LJ, et al. (2006) Carotid baroreflex regulation of vascular resistance in high altitude Andean natives with and without chronic mountain siskness. Exp Physiol 91:907-914
46. Moore JP, Hainsworth R, Drinkhill MJ (2004) Phasic negative intrathoracic pressures enhance the vascular responses to stimulation of pulmonary arterial baroreceptors in closed-chest anaesthetized dogs. J Physiol 555:815-824
47. Moore JP, Rivera-Chira M, Macarlupu JL, et al. (2004) Carotid baroreflex regulation of vascular resistance in lowland and high altitude anaesthetized dogs. J Physiol 560:PC11
48. Morel OE, Buvry A, Le Corvoisier P, et al. (2003) Effects of nifedipine-induced pulmonary vasodilatation on cardiac receptors and protein kinase C isoforms in the chronically hypoxic rat. Pflugers Archiv 446:356-364
49. Moudgil R, Michelakis ED, Archer SL (2005) Hypoxic pulmonary vasoconstriction. J Appl Physiol 98:390-403
50. Norcliffe LJ, Rivera M, Palacios AJ, et al. (2005) Cerebrovascular Responses to Hypoxia and Hypocapnia in High Altitude Dwellers. J Physiol (Lond) 566:287-294
51. Otsuka K, Norboo T, Otsuka Y, et al. (2005) Chronoecological health watch of arterial stiffness and neuro-cardiopulmonary function in elderly community at high altitude (3524 m) compared with Japanese town. Biomed Pharmacother 59(suppl 1):S58-S67
52. Otsuka K, Norboo T, Otsuka Y, et al. (2005) Effect of aging on blood pressure in Leh, Ladakha, a high altitude community by comparison with a Japanese town. Biomed Pharmacother 59(suppl 1):S54-S57
53. Piletz JE, Andorn AC, Unnerstall JR, Halaris A (1991) Binding of [3H]-paminoclonidine to alpha 2-adrenoceptor states plus a non-adrenergic site on human platelet plasma membranes. Biochem Pharmacol 42:569-584
54. Reeves JT, Groves BM, Sutton JT et al. (1987) Operation Everest II: preservation of cardiac function at extreme altitude. J Appl Physiol 63:531-539
55. Reis DJ, Golanov EV, Ruggiero DA, Sun MK (1994) Sympatho-excitatory neurons of the rostral ventrolateral medulla are oxygen sensors and essential elements in the tonic and reflex control of the systemic and cerebral circulations. J Hypertens 12:S159-S180
56. Richalet JP, Larmignat P, Rathat C, Keromes A, Baud P, Lhoste F (1988) Decreased cardiac response to isoproterenol infusion in acute and chronic hypoxia. J Appl Physiol 65:1957-1961
57. Riley DJ (1991) Vascular remodelling in the lung: Scientific Foundations (eds Cristal RC, West JB) Raven Press, New York, pp 1189-1198
58. Roach R, Passino C, Bernardi L, Gamboa J, Gamboa A, Appenzeller O (2001) Cerebrovascular reactivity to CO2 at high altitude and sea level in Andean Natives. Clin Auton Res 11:183
59. Rostrup M (1998) Catecholamines, hypoxia and high altitude. Acta Physiol Scand 162:389-399
60. Rowell LB, Blackmon JR (1986) Lack of sympathetic vasoconstriction in hypoxemic humans at rest. Am J Physiol 251:H562-H570
61. Sagawa S, Torii R, Nagaya K, Wada F, Endo Y, Shiraki K (1997) Carotid baroreflex control of heart rate during acute exposure to simulated altitudes of 3,800 m and 4,300 m. Am J Physiol 273:R1219-R1223
62. Severinghaus JW, Bainton CR, Carcelen A (1966) Respiratory insensitivity to hypoxia in chronically hypoxic man. Resp Physiol 1:308-334
63. Sevre K, Bendz B, Hanko E, et al. (2001) Reduced autonomic activity during stepwise exposure to high altitude. Acta Physiol Scand 173:409-417
64. Sime F, Monge CC, Whittembury J (1975) Age as a cause of chronic mountain sickness. Int J Biometeorol 19:93-98
65. Talbot NP, Balanos GM, Dorrington KL, Robbins PA (2005) Two temporal components within the human pulmonary vascular response to 2 h of isocapnic hypoxia. J Appl Physiol 98:1125-1139
66. Villafuerte FC, Cardenas R, Monge CC (2004) Optimal haemoglobin concentration and high altitude: a theoretical approach for Andean men at rest. J Appl Physiol 96:1579-1580
67. Voelkel NF, Hegstrand L, Reeves JT, McMurty IF, Molinoff PB (1981) Effects of hypoxia on density of beta-adrenergic receptors. J Appl Physiol 50:363-366
68. Vogel JA, Harris CW (1967) Cardiopulmonary responses of resting man during early exposure to high altitude. J Appl Physiol 22:1124-1128
69. Vogel JA, Hansen JE, Harris CW (1967) Cardiovascular responses in man during exhaustive work at sea level and high altitude. J Appl Physiol 23:531-539
70. WHO (1996) World Health Statistics Annual 1995. World Health Organization, Geneva
71. Young PM, Sutton JR, Green HJ, et al. (1992) Operation Everest II: metabolic and hormonal responses to incremental exercise to exhaustion. J Appl Physiol 73:2574-2579
72. Zhao L, Mason NA, Morrell NW, et al. (2001) Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 104:424-428