Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats

International Journal of Neuroscience

Volumn 117, Issue 1, 2007, Pages 47-62

  Gultekin, Fatih ^a   Karakoyun, Inanc ^a   Sutcu, Recep ^a   Savik, Emin ^a   Cesur, Gokhan ^a   Orhan, Hikmet ^b   Delibas, Namik ^a  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b SULEYMAN DEMIREL UNIVERSITY   (Turkey)

Author keywords

Chlorpyrifos; Learning; Memory; NR2A; NR2B; Rat

Indexed keywords

ACETYLCHOLINESTERASE; BRAIN PROTEIN; CHLORPYRIFOS; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME INHIBITION; LEARNING; MALE; MEMORY; NONHUMAN; RAT;

ACETYLCHOLINESTERASE; AGE FACTORS; ANIMALS; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; INSECTICIDES; MALE; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; STATISTICS, NONPARAMETRIC;

EID: 33846974350     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.1080/00207450500535719     Document Type: Article

References (42)

1. Abou-Donia, M. B., Wilmarth, K. R., Abdel-Rahman, A. A., Jensen, K. F., Oehme, F. W., & Kurt, T. L. (1996). Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos. Fundamental and Applied Toxicology, 34(2), 201-222.
2. Altuntas, I., Delibas, N., Doguc, D.K., Ozmen, S., & Gultekin, F. (2003). Role of reactive oxygen species in organophosphate insecticide phosalone toxicity in erythrocytes in vitro. Toxicology in Vitro, 17(2), 153-157.
3. Altuntas, I., Kilinc, I., Orhan, H., Demirel, R., Koylu, H., & Delibas, N. (2004). The effects of diazinon on lipid peroxidation and antioxidant enzymes in erythrocytes in vitro. Human and Experiemental Toxicology, 23(1), 9-13.
4. Bagchi, D., Bagchi, M., Hassoun, E. A., & Stohs, S. J. (1995). In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology, 104, 129-140.
5. Bushnell, P. J., Kelly, K. L., & Ward, T. R. (1994). Repeated inhibition of cholinesterase by chlorpyrifos in rats: Behavioral, neurochemical and pharmacological indices of tolerance. Journal of Pharmacology and Experimental Therapeutics, 270(1), 15-25.
6. Carr, R. L., Chambers, H.W., Guarisco, J.A., Richardson, J. R., Tang, J., & Chambers, J. E. (2001). Effects of repeated oral postnatal exposure to chlorpyrifos on open-field behavior in juvenile rats. Toxicological Sciences, 59(2), 260-267.
7. Crumpton, T. L., Seidler, F. J., & Slotkin, T. A. (2000). Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos? Brain Research. Developmental Brain Research, 121(2), 189-195.
8. Dam, K., Garcia, S. J., Seidler, F. J., & Slotkin, T. A. (1999). Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. Brain Research. Developmental Brain Research, 116(1), 9-20.
9. Dam, K., Seidler, F. J., & Slotkin, T. A. (2000). Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Brain Research. Developmental Brain Research, 121(2), 179-187.
10. Gultekin, F., Ozturk, M., & Akdogan, M. (2000). The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro). Archives of Toxicology, 74, 533-538.
11. Gultekin, F., Delibas, N., Yasar, S., & Kilinc, I. (2001). In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats. Archives of Toxicology, 75, 88-96.
12. Gultekin, F., Delibas, N., Kutluhan, S., Akdogan, M., Kilinc, I., & Sutcu, R. (2001). The chances in antioxidant system caused by chlorpyrifos-ethyl in rat brain and protective effect of melatonin and vitamin C + vitamin E. Selcuk Universitesi Tip Fakultesi Dergisi, 17, 79-86.
13. Hayes, W. J., & Laws, E. R. (1990). Handbook of Pesticide Toxicology, Vol. 3: Classes of Pesticides. New York: Academic Press, Inc.
14. Heresco-Levy, U. (2003). Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality. Progress in Neuropsychopharmacology and Biological Psychiatry, 27(7), 1113-1123.
15. Hsieh, C. Y., Leslie, F.M., & Metherate, R. (2002). Nicotine exposure during a postnatal critical period alters NR2A and NR2B mRNA expression in rat auditory forebrain. Brain Research. Developmental Brain Research, 133(1), 19-25.
16. Hynd, M. R., Scott, H. L., & Dodd, P. R. (2004). Differential expression of Nmethyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease. Journal of Neurochemistry, 90(4), 913-919.
17. Icenogle, L. M., Christopher, N. C., Blackwelder, W. P., Caldwell, D. P., Qiao, D., Seidler, F. J., Slotkin, T. A., & Levin, E. D. (2004). Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicology and Teratology, 26(1), 95-101.
18. Jett, D. A., Navoa, R. V., Beckles, R. A., & McLemore, G. L. (2001). Cognitive function and cholinergic neurochemistry in weanling rats exposed to chlorpyrifos. Toxicology and Applied Pharmacology, 174(2), 89-98.
19. Karanth, S., & Pope, C. (2003). Age-related effects of chlorpyrifos and parathion on acetylcholine synthesis in rat striatum. Neurotoxicology and Teratology, 25(5), 599-606.
20. Kousba, A. A., Poet, T. S., & Timchalk, C. (2003). Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase:Apotential biomonitoring matrix. Toxicology, 188, 219-232.
21. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227(5259), 680-685.
22. Levin, E. D., Addy, N., Nakajima, A., Christopher, N. C., Seidler, F. J., & Slotkin, T. A. (2001). Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Brain Research. Developmental Brain Research, 130(1), 83-89.
23. Levin, E. D., Addy, N., Baruah, A., Elias, A., Christopher, N. C., Seidler, F. J., & Slotkin, T. A. (2002). Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicology and Teratology, 24(6), 733-741.
24. Levin, E. D., Sledge, D., Baruah, A., & Addy, N. A. (2003). Ventral hippocampal NMDA blockade and nicotinic effects onmemory function. Brain Research Bulletin, 61(5), 489-495.
25. Liu, J., & Pope, C. N. (1998). Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion. Journal of Toxicology and Environmental Health, 53(7), 531-544.
26. Mortensen, S. R., Chanda, S. M., Hooper, M. J., & Padilla, S. (1996). Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos. Journal of Biochemical Toxicology, 11(6), 279-287.
27. Nostrandt, A. C., Padilla, S., & Moser, V. C. (1997). The relationship of oral chlorpyrifos effects on behavior, cholinesterase inhibition, and muscarinic receptor density in rat. Pharmacology, Biochemistry and Behavior, 58(1), 15-23.
28. Ozawa, S., Kamiya, H., & Tsuzuki, K. (1998). Glutamate receptors in the mammalian central nervous system. Progress in Neurobiology, 54(5), 581-618.
29. Pavlovsky, L., Browne, R. O., & Friedman, A. (2003). Pyridostigmine enhances glutamatergic transmission in hippocampal CA1 neurons. Experimental Neurology, 179(2), 181-187.
30. Pope, C. N., Chakraborti, T. K., Chapman, M. L., & Farrar, J. D. (1992). Long-term neurochemical and behavioral effects induced by acute chlorpyrifos treatment. Pharmacology, Biochemistry and Behavior, 42(2), 251-256.
31. Richardson, R. J. (1995). Assessment of the neurotoxic potential of chlorpyrifos relative to other organophosphorus compounds: A critical review of the literature. Journal of Toxicology and Environmental Health, 44(2), 135-165.
32. Schardein, J. L., & Scialli, A. R. (1999). The legislation of toxicologic safety factors: The Food Quality Protection Act with chlorpyrifos as a test case. Reproductive Toxicology, 13(1), 1-14.
33. Schuh, R. A., Lein, P. J., Beckles, R. A., & Jett, D. A. (2002). Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: Altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicology and Applied Pharmacology, 182(2), 176-185.
34. Slotkin, T. A. (1999). Developmental cholinotoxicants: Nicotine and chlorpyrifos. Environmental Health Perspectives, 107(1), 71-80.
35. Slotkin, T. A., Cousins, M. M., Tate, C. A., & Seidler, F. J. (2001). Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Research, 902(2), 229-243.
36. Stanton, M. E., Mundy, W. R., Ward, T., Dulchinos, V., & Barry, C. C. (1994). Time-dependent effects of acute chlorpyrifos administration on spatial delayed alternation and cholinergic neurochemistry in weanling rats. Neurotoxicology, 15(1), 201-208.
37. Steenland, K., Dick, R. B., Howell, R. J., et al. (2000). Neurologic function among termiticide applicators exposed to chlorpyrifos. Environmental Health Perspectives, 108(4), 293-300.
38. Tamer, D. (2002). Functinal Neuroanatomy. 3rd edn. (pp. 226-231). Ankara: ODTU Improvement Foundation Publishing and Communication Company-Metu Press.
39. Tang, Y. P., Shimizu, E., Dube, G. R., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999). Genetic enhancement of learning and memory in mice. Nature, 401(6748), 63-69.
40. Tsukada, H., Kakiuchi, T., Shizuno, H., & Nishiyama, S. (1998). Interactions of cholinergic and glutamatergic neuronal systems in the functional activation of cerebral blood flow response: A PET study in unanesthetized monkeys. Brain Research, 796(1-), 82-90.
41. Wirkner, K., Poelchen, W., Koles, L., Muhlberg, K., Scheibler, P., Allgaier, C., & Illes, P. (1999). Ethanol-induced inhibition of NMDA receptor channels. Neurochemistry International, 35(2), 153-162.
42. Zheng, Q., Olivier, K., Won, Y. K., & Pope, C. N. (2000). Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats. Toxicological Sciences, 55(1), 124-132.