Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?

Neurocritical Care

Volumn 5, Issue 3, 2006, Pages 173-175

  Larsen, Fin Stolze ^a  

^a University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 1; LACTIC ACID; PYRUVIC ACID;

BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN DAMAGE; BRAIN METABOLISM; EDITORIAL; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; INTRACRANIAL PRESSURE; LIVER FAILURE; MICRODIALYSIS; PATIENT MONITORING; PRIORITY JOURNAL;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD GLUCOSE; BRAIN; BRAIN EDEMA; CRITICAL CARE; EXTRACELLULAR FLUID; HEPATIC ENCEPHALOPATHY; HUMANS; INTRACRANIAL PRESSURE; LACTIC ACID; LIVER FAILURE, ACUTE; MICRODIALYSIS; MONITORING, PHYSIOLOGIC; PYRUVIC ACID;

EID: 33846968862     PISSN: 15416933     EISSN: None     Source Type: Journal    
DOI: 10.1385/NCC:5:3:173     Document Type: Editorial

References (18)

1. Raghavan M, Marik PE. Therapy of intracranial hypertension in patients with fulminant hepatic failure. Neurocrit Care 2006;4(2):179-189.
2. Blei AT, Larsen FS. Pathophysiology of cerebral edema in fulminant hepatic failure. J Hepatol 1999;31(4):771-776.
3. Rao KV, Norenberg MD. Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia. Metab Brain Dis 2001;16(1-2):67-78.
4. Tofteng F, Hauerberg J, Hansen BA, Pedersen CB, Jorgensen L, Larsen FS. Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 2006;26(1):21-27.
5. Hutchinson PJ, Gimson A, Al-Rawi PG, O'Connell MT, Czosnyka M, Menon DK. Case report: Microdialysis in the management of hepatic encephalopathy. Neurocritical Care 2006; in press.
6. Tofteng F, Jorgensen L, Hansen BA, Ott P, Kondrup J, Larsen FS. Cerebral microdialysis in patients with fulminant hepatic failure. Hepatology 2002;36(6):1333-1340.
7. Vaquero J, Fontana RJ, Larson AM, et al. Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy. Liver Transpl 2005;11(12):1581-1589.
8. Bernuau J. Acute liver failure: avoidance of deleterious cofactors and early specific medical therapy for the liver are better than late intensive care for the brain. J Hepatol 2004;41(1):152-155.
9. Wendon J, Larsen FS. Intracranial pressure monitoring in patients with acute liver failure: A procedure with clear indications. Hepatology 2006; in press.
10. Hutchinson PJ, O'Connell MT, al-Rawi PG, Kett-White R, Gupta AK, Kirkpatrick. PJ, Pickard JD. Clinical cerebral microdialysis - determining the true extracellular concentration. Acta Neurochir Suppl 2002;81:359-362.
11. Larsen FS. Cerebral circulation in liver failure. Semin Liver Dis 1996;16(3):281-292.
12. Wendon JA, Harrison PM, Keays R, Williams R. Cerebral blood flow and metabolism in fulminant liver failure. Hepatology 1994;19(6):1407-1413.
13. Aggarwal S, Obrist W, Yonas H, Kramer D, Kang Y, Scott V, Planinsic R. Cerebral hemodynamic and metabolic profiles in fulminant hepatic failure: relationship to outcome. Liver Transpl 2005;11(11):1353-1360.
14. Belanger M, Desjardins P, Chatauret N, Butterworth RF. Selectively increased expression of the astrocytic/endothelial glucose transporter protein GLUT1 in acute liver failure. Glia 2006;53(5):557-562.
15. Felipo V, Butterworth RF. Neurobiology of ammonia. Prog Neurobiol 2002;67(4):259-279.
16. Martinez-Hernandez A, Bell KP, Norenberg MD. Glutamine synthe tase: glial localization in brain. Science 1977;195(4284):1356-1358.
17. Zwingmann C, Chatauret N, Leibfritz D, Butterworth RF. Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study. Hepatology 2003;37(2):420-428.
18. Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int 2005;47(1-2):13-18.