Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites

Pediatric Research

Volumn 61, Issue 1, 2007, Pages 61-66

  Duan, Rui Dong ^a   Cheng, Yajun ^a   Jönsson, Bo A G ^a   Ohlsson, Lena ^a   Herbst, Andreas ^a   Hellström Westas, Lena ^a   Nilsson, Åke ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLSPHINGOSINE DEACYLASE; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE; AMIDASE;

ALKALINITY; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; ENZYME INACTIVATION; ENZYME SUBSTRATE; ENZYME SYNTHESIS; FEMALE; GESTATIONAL AGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; MALE; MASS SPECTROMETRY; MECONIUM; MECONIUM ASPIRATION; NEWBORN; NEWBORN PERIOD; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TERM BIRTH; ENZYMOLOGY; METABOLISM; PHYSIOLOGY;

AMIDOHYDROLASES; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MALE; MECONIUM; SPHINGOLIPIDS; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 33846953231     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000250534.92934.c2     Document Type: Article

References (40)

1. Nilsson A, Duan RD 2006 Absorption and lipoprotein transport of sphingomyelin. J Lipid Res 47:154-171
2. Pettus BJ, Chalfant CE, Hannun YA 2002 Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta 1585:114-125
3. Levade T, Andrieu-Abadie N, Segui B, Auge N, Chatelut M, Jaffrezou JP, Salvayre R 1999 Sphingomyelin-degrading pathways in human cells role in cell signalling. Chem Phys Lipids 102:167-178
4. Nilsson A 1968 Metabolism of sphingomyelin in the intestinal tract of the rat. Biochim Biophys Acta 164:575-584
5. Nilsson A 1969 The presence of spingomyelin- and ceramide-cleaving enzymes in the small intestinal tract. Biochim Biophys Acta 176:339-347
6. Nilsson A, Duan RD 1999 Alkaline sphingomyelinases and ceramidases of the gastrointestinal tract. Chem Phys Lipids 102:97-105
7. Hannun YA, Luberto C, Argraves KM 2001 Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry 40:4893-4903
8. Pyne S 2002 Cellular signaling by sphingosine and sphingosine 1-phosphate. Their opposing roles in apoptosis. Subcell Biochem 36:245-268
9. Cuvillier O 2002 Sphingosine in apoptosis signaling. Biochim Biophys Acta 1585:153-162
10. Zeisel SH, Mar MH, Howe JC, Holden JM 2003 Concentrations of choline-containing compounds and betaine in common foods. J Nutr 133:1302-1307
11. Vesper H, Schmelz EM, Nikolova-Karakashian MN, Dillehay DL, Lynch DV, Merrill AH Jr 1999 Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J Nutr 129:1239-1250
12. Duan RD, Nilsson A 1997 Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity. Hepatology 26:823-830
13. Duan RD, Bergman T, Xu N, Wu J, Cheng Y, Duan J, Nelander S, Palmberg C, Nilsson A 2003 Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. J Biol Chem 278:38528-38536
14. Wu J, Nilsson A, Jonsson BA, Stenstad H, Agace W, Cheng Y, Duan RD 2006 Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. Biochem J 394:299-308
15. Amer MD, Hedlund E, Rochester J, Caplan MS 2004 Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis. Biol Neonate 85:159-166
16. Olsson M, Duan RD, Ohlsson L, Nilsson A 2004 Rat intestinal ceramidase: purification, properties, and physiological relevance. Am J Physiol Gastrointest Liver Physiol 287:G929-G937
17. Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL 2006 Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem 281:7324-7331
18. Duan RD, Cheng Y, Hansen G, Hertervig E, Liu JJ, Syk I, Sjostrom H, Nilsson A 2003 Purification, localization, and expression of human intestinal alkaline sphingomyelinase. J Lipid Res 44:1241-1250
19. Wu J, Liu F, Nilsson A, Duan RD 2004 Pancreatic trypsin cleaves intestinal alkaline sphingomyelinase from mucosa and enhances the sphingomyelinase activity. Am J Physiol Gastrointest Liver Physiol 287:G967-G973
20. Di Marzio L, Di Leo A, Cinque B, Fanini D, Agnifili A, Berloco P, Linsalata M, Lorusso D, Barone M, De Simone C, Cifone MG 2005 Detection of alkaline sphingomyelinase activity in human stool: proposed role as a new diagnostic and prognostic marker of colorectal cancer. Cancer Epidemiol Biomarkers Prev 14:856-862
21. Trier JS, Moxey PC 1979 Morphogenesis of the small intestine during fetal development. Ciba Found Symp Jan 16-18:3-29
22. Lillienau J, Cheng Y, Nilsson A, Duan RD 2003 Development of intestinal alkaline sphingomyelinase in rat fetus and newborn rat. Lipids 38:545-549
23. Montgomery RK, Mulberg AE, Grand RJ 1999 Development of the human gastrointestinal tract: twenty years of progress. Gastroenterology 116:702-731
24. Motouri M, Matsuyama H, Yamamura J, Tanaka M, Aoe S, Iwanaga T, Kawakami H 2003 Milk sphingomyelin accelerates enzymatic and morphological maturation of the intestine in artificially reared rats. J Pediatr Gastroenterol Nutr 36:241-247
25. Zagariya A, Bhat R, Chari G, Uhal B, Navale S, Vidyasagar D 2005 Apoptosis of airway epithelial cells in response to meconium. Life Sci 76:1849-1858
26. Bellander M, Ley D, Polberger S, Hellstrom-Westas L 2003 Tolerance to early human milk feeding is not compromised by indomethacin in preterm infants with persistent ductus arteriosus. Acta Paediatr 92:1074-1078
27. Duan RD, Nilsson A 2000 Sphingolipid hydrolyzing enzymes in the gastrointestinal tract. Methods Enzymol 311:276-286
28. Lundgren P, Nilsson A, Duan RD 2001 Distribution and properties of neutral ceramidase activity in rat intestinal tract. Dig Dis Sci 46:765-772
29. Wu J, Cheng Y, Jonsson BA, Nilsson A, Duan RD 2005 Acid sphingomyelinase is induced by butyrate but does not initiate the anticancer effect of butyrate in HT29 and HepG2 cells. J Lipid Res 46:1944-1952
30. Malmsten M, Bergenstahl B, Nyberg L, Oldham G 1994 Sphingomyelin from milk - characterization of crystalline, liposome and emulsion properties. J Am Oil Chem Soc 71:1021-1026
31. Bouhours JF, Guignard H 1979 Free ceramide, sphingomyelin, and glucosylceramide of isolated rat intestinal cells. J Lipid Res 20:879-907
32. Duan RD, Nyberg L, Nilsson A 1995 Alkaline sphingomyelinase activity in rat gastrointestinal tract: distribution and characteristics. Biochim Biophys Acta 1259:49-55
33. Nyberg L, Farooqi A, Blackberg L, Duan RD, Nilsson A, Hernell O 1998 Digestion of ceramide by human milk bile salt-stimulated lipase. J Pediatr Gastroenterol Nutr 27:560-567
34. Kirby RJ, Zheng S, Tso P, Howles PN, Hui DY 2002 Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis. J Biol Chem 277:4104-4109
35. McGuire W, Anthony MY 2003 Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review. Arch Dis Child Fetal Neonatal Ed 88:F11-F14
36. Carlson SE, Montalto MB, Ponder DL, Werkman SH, Korones SB 1998 Lower incidence of necrotizing enterocolitis in infants fed a preterm formula with egg phospholipids. Pediatr Res 44:491-498
37. Karlsson KA, Larson G 1978 Molecular characterization of cell-surface antigens of human fetal tissue: meconium, a rich source of epithelial blood-group glycolipids. FEBS Lett 87:283-287
38. Larson G, Watsfeldt P, Falk P, Leffler H, Koprowski H 1987 Fecal excretion of intestinal glycosphingolipids by newborns and young children. FEBS Lett 214:41-44
39. Taki T, Rokukawa C, Kasama T, Kon K, Ando S, Abe T, Handa S 1992 Human meconium gangliosides. Characterization of a novel I-type ganglioside with the NeuAc alpha 2-6Gal structure. J Biol Chem 267:11811-11817
40. Holopainen R, Aho H, Laine J, Peuravuori H, Soukka H, Kaapa P 1999 Human meconium has high phospholipase A2 activity and induces cellular injury and apoptosis in piglet lungs. Pediatr Res 46:626-632