Digestion of ceramide by human milk bile salt-stimulated lipase

Journal of Pediatric Gastroenterology and Nutrition

Volumn 27, Issue 5, 1998, Pages 560-567

  Nyberg, Lena ^a   Farooqi, Aijaz ^b   Bläckberg, Lars ^b   Duan, Rui Dong ^c   Nilsson, Åke ^c   Hernell, Olle ^b  

^a Swedish Dairies' Association   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bile salt stimulated lipase; Breast fed newborn; Ceramidase; Lipid digestion; Sphingolipid; Sphingomyelinase

Indexed keywords

ACYLSPHINGOSINE DEACYLASE; BILE SALT; CERAMIDE; GLYCOCHENODEOXYCHOLIC ACID; GLYCOCHOLIC ACID; GLYCODEOXYCHOLIC ACID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TRIACYLGLYCEROL LIPASE;

ARTICLE; BREAST FEEDING; BREAST MILK; CONTROLLED STUDY; DIGESTION; ENZYME ACTIVITY; FEMALE; HUMAN; HYDROLYSIS; LIPID METABOLISM; PH; PRIORITY JOURNAL; WHEY;

AMIDOHYDROLASES; CERAMIDES; CHOLESTEROL ESTERASE; DIGESTION; FATTY ACIDS; HUMANS; HYDROLYSIS; MILK, HUMAN; PHOSPHORYLCHOLINE; SPHINGOSINE;

EID: 0031785063     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005176-199811000-00013     Document Type: Article

References (37)

1. Barenholz Y, Thompson TE. Sphingomyeline in bilayers and biological membranes. Biochim Biophys Acta 1980;604:129-58.
2. Mitchell RH, Wakelam MJO. Sphingolipid signaling. Curr Biol 1994;4:370-3.
3. Liscovitch M, Cantley LC. Lipid second messengers. Cell 1994; 77:329-34.
4. Bell RM. Sphingolipid metabolites function in multiple cellular signal transduction pathways. J Lipid Med Cell Signal 1994;10: 19-21.
5. Hannun YA, Loomis CR, Merrill A, Bell RM. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem 1986;261: 12604-9.
6. Hannun YA, Bell RM. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 1987;243: 500-7.
7. Dillehay DL, Webb SK, Schmelz E-M, Merrill AH. Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice. J Nutr 1994;124:615-20.
8. Nilsson Å. The presence of Sphingomyelin and ceramide cleaving enzymes in the small intestinal tract. Biochim Biophys Acta 1969; 176:339-47.
9. Nilsson Å. Metabolism of sphingomyelin in the intestinal tract of the rat. Biochim Biophys Acta 1968;164:575-84.
10. Schmelz EM, Crall KJ, Larocque R, Dillehay DL, Merrill AH. Uptake and metabolism of sphingolipids in isolated intestinal loops of mice. J Nutr 1994;124:702-12.
11. Duan R-D, Nyberg L, Nilsson Å. Alkaline sphingomyelinase activity in rat gastrointestinal tract: Distribution and characteristics. Biochim Biophys Acta 1995;1259:49-55.
12. Nyberg L, Duan R-D, Axelsson J, Nilsson Å. Identification of an alkaline sphingomyelinase activity in human bile. Biochim Biophys Acta 1996;1300:42-8.
13. Zeisel SH. Choline deficiency. J Nutr Biochem 1990;1:332-49.
14. Bitman J, Wood L, Mehta NR, Hamosh P, Hamosh M. Comparison of the phospholipid composition of breast milk from mothers of term and preterm infants during lactation. Am J Clin Nutr 1984; 40:103-19.
15. Canty DJ, Zeisel SH. Lecithin and choline in human health and disease. Nutr Rev 1994;52:327-39.
16. Jensen RG, Clark RM, Ferris AM. Composition of the lipids in human milk: A review. Lipids 1980;15:345-55.
17. Nilsson J, Bläckberg L, Carlsson P, Enerbäck S, Hernell O, Bjursell G. cDNA cloning of human milk bile salt-stimulated lipase and evidence for its identity with to carboxylic ester hydrolase. Eur J Biochem 1991;192:543-50.
18. Nyberg L, Burling H. Method for extracting sphingomyelin. SE-Patent 9300454-7.
19. Christie W. Rapid separation and quantification of lipid classes by HPLC and mass detection. J Lipid Res 1985;26:507-12.
20. Malmsten M, Bergenståhl B, Nyberg L, Odham G. Sphingomyelin from milk: Characterization of liquid crystalline, liposome and emulsion properties. J Amer Oil Chem Soc 1994;71:1021-6.
21. Bläckberg L, Hernell O. The bile-salt stimulated lipase in human milk. Purification and characterization. Eur J Biochem 1981;116: 221-5.
22. Bläckberg L, Strömqvist M, Edlund M, et al. Recombinant human milk bile salt-stimulated lipase. Functional properties are retained in the absence of glycosylation and the unique proline-rich repeats. Eur J Biochem 1995;228:817-21.
23. Stoffel W. Chemical synthesis of choline-labeled lecithins and sphingomyelins. Meth Enzymol 1975;355:533-41.
24. Belfrage P, Vaughn M. Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res 1969;10:341-44.
25. Järvenpää AL, Rassin DK, Kuitunen P, Gaull GE, Räihä NCR. Feeding the low-birth-weight infant: III. Diet influences bile acid metabolism. Pediatrics 1983;72:677-83.
26. Gatt S. Magnesium-dependent sphingomyelinase. Biochem Biophys Res Comm 1976;1:235-41.
27. Carey MC, Hernell O. Digestion and absorption of fat. Semin Gastrointest Dis 1992;3:189-208.
28. Hamosh M. Lipid metabolism in pediatric nutrition. Pediatr Clin North Am 1995;42:839-59.
29. Hernell O, Bläckberg L. Digestion and absorption of human milk lipids In: Dulbecco R, ed. Encyclopedia of human biology. 2nd ed. Vol 3. San Diego: Academic Press, 1997:319-28.
30. Bläckberg L, Hernell O. Further characterization of the bile salt-stimulated lipase in human milk. FEBS Lett. 1983;157:337-41.
31. Van den Bosch H, Aarsman AJ, De Jong JGN, Van Deenen LLM. Studies on lysophospholipases: I. Purification and some properties of a lysophospholipase from beef pancreas. Biochim Biophys Acta 1973;296:94-104.
32. Hui DY, Hayakawa K, Oizumi J. Lipoamidase activity in normal and mutagenized pancreatic cholesterol esterase (bile salt-stimulated lipase). Biochem J 1993;291:65-9.
33. Hansson L, Bläckberg L, Edlund M, Lundberg L, Strömqvist M, Hernell O. Recombinant human milk bile salt-stimulated lipase: Catalytic activity is retained in the absence of glycosylation and the unique proline-rich repeats. J Biol Chem 1993;268:26692-8.
34. Hernell O, Bläckberg L. Human milk bile salt-stimulated lipase: Functional and molecular aspects. J Pediatr 1994;125(Suppl): S56-S61.
35. Duan R-D, Hertervig E, Nyberg L, et al. Distribution of alkaline sphingomyelinase activity in human beings and animals: Tissue and species differences. Dig Dis Sci 1996;9:1801-6.
36. Fredrikzon B, Hernell O, Bläckberg L, Olivecrona T. Bile salt-stimulated lipase in human milk: Evidence for activity in vivo and of a role in the digestion of milk retinol esters. Pediatr Res 1978; 12:1048-52.
37. Bosner MS, Gulick T, Riley DJS, Spilburg CA, Lange LG. Heparin-modulated binding of pancreatic lipase and uptake of hydrolyzed triglycerides in the intestine. J Biol Chem 1989;264: 20261-4.