Increased hydrogen peroxide concentration in the exhaled breath condensate of stable COPD patients after nebulized N-acetylcysteine

Pulmonary Pharmacology and Therapeutics

Volumn 20, Issue 3, 2007, Pages 281-289

  Rysz, Jacek ^a   Stolarek, Robert A ^a   Luczynski, Rafal ^a   Sarniak, Agata ^a   Wlodarczyk, Anna ^a   Kasielski, Marek ^a   Nowak, Dariusz ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Chronic obstructive pulmonary disease; Exhaled breath condensate; Hydrogen peroxide; N acetylcysteine; Nitrates; Nitrites

Indexed keywords

ACETYLCYSTEINE; HOMOVANILLIC ACID; HYDROGEN PEROXIDE; NITRATE; NITRITE; NITRITE REDUCTASE [NAD(P)H]; PLACEBO; THIOL;

AGED; ARTICLE; BREATHING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; MALE; NEBULIZATION; OXIDATION; PRIORITY JOURNAL;

ACETYLCYSTEINE; AGED; ANALYSIS OF VARIANCE; BREATH TESTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXHALATION; EXPECTORANTS; EXPIRATORY RESERVE VOLUME; FEMALE; FORCED EXPIRATORY FLOW RATES; FORCED EXPIRATORY VOLUME; HUMANS; HYDROGEN PEROXIDE; MALE; MIDDLE AGED; NEBULIZERS AND VAPORIZERS; NITRATES; NITRITES; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SULFHYDRYL COMPOUNDS;

EID: 33846930874     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2006.03.011     Document Type: Article

References (38)

1. Rahman I. Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms. Cell Biochem Biophys 43 (2005) 167-188
2. Adcock I.M., Cosio B., Tsaprouni L., Barnes P.J., and Ito K. Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response. Antioxid Redox Signal 7 (2005) 144-152
3. Tsoumakidou M., Tzanakis N., Chrysofakis G., and Siafakas N.M. Nitrosative stress, heme oxygenase-1 expression and airway inflammation during severe exacerbation of COPD. Chest 127 (2005) 1911-1918
4. Ichinose M., Sugiura H., Yamagata S., Koarai A., and Shirato K. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am J Respir Crit Care Med 162 2 Part 1 (2000) 701-706
5. Barnes P.J., Ito K., and Adcock I.M. Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet 363 9410 (2004) 731-733
6. Forman H.J., Fukuto J.M., and Torres M. Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers. Am J Physiol Cell Physiol 287 (2004) C246-C256
7. Lawler J.M., and Song W. Specificity of antioxidant enzyme inhibition in skeletal muscle to reactive nitrogen species donors. Biochem Biophys Res Commun 294 (2002) 1093-1100
8. Rutgers S.R., van der Mark T.W., Coers W., Moshage H., Timens W., Kauffman H.F., et al. Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease. Thorax 54 (1999) 576-580
9. Mutlu G.M., Garey K.W., Robbins R.A., et al. Collection and analysis of exhaled breath condensate in humans. Am J Respir Crit Care Med 164 (2001) 731-737
10. Corradi M., Pesci A., Casana R., Alinovi R., Goldoni M., Vettori M.V., et al. Nitrate in exhaled breath condensate of patients with different airway diseases. Nitric Oxide 8 (2003) 26-30
11. De Benedetto F., Aceto A., Dragani B., Spacone A., Formisano S., Pela R., et al. Long-term oral N-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD. Pulm Pharmacol Ther 18 (2005) 41-47
12. Nowak D., Kasielski M., Antczak A., Pietras T., and Bialasiewicz P. Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smoking. Respir Med 93 (1999) 389-396
13. Dekhuijzen P.N., Aben K.K., Dekker I., Aarts L.P., Wielders P.L., van Herwaarden C.L., et al. Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 154 (1996) 813-816
14. Kasielski M., and Nowak D. Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease. Respir Med 95 (2001) 448-456
15. Szkudlarek U., Zdziechowski A., Witkowski K., Kasielski M., Luczynska M., Luczynski R., et al. Effect of inhaled N-acetylcysteine on hydrogen peroxide exhalation in healthy subjects. Pulm Pharmacol Ther 17 (2004) 155-162
16. 2/chloride system to inhibit LDL oxidation. Biochem Biophys Res Commun 337 (2005) 82-88
17. Aruoma O.I., Halliwell B., Hoey B.M., and Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radical Biol Med 6 (1989) 593-597
18. Edlundh-Rose E., Kupershmidt I., Gustafsson A.C., Parasassi T., Serafino A., Bracci-Laudiero L., et al. Gene expression analysis of human epidermal keratinocytes after N-acetyl l-cysteine treatment demonstrates cell cycle arrest and increased differentiation. Pathobiology 72 (2005) 203-212
19. Voelkel N., and Taraseviciene-Stewart L. Emphysema: an autoimmune vascular disease?. Proc Am Thorac Soc 2 (2005) 23-25
20. Kinnula V.L. Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases. Thorax 60 (2005) 693-700
21. Fukagawa N.K., Ajami A.M., and Young V.R. Plasma methionine and cysteine kinetics in response to an intravenous glutathione infusion in adult humans. Am J Physiol 270 (1996) E209-E214
22. GOLD Workshop Report. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (2005), NHLBI, Bethesda, MD
23. American Thoracic Society. Standardization of spirometry: 1994 update. Am J Respir Crit Care Med 152 (1995) 1107-1136
24. Single-breath carbon monoxide diffusing capacity (transfer factor). Recommendations for a standard technique-1995 update. Am J Respir Crit Care Med 152 (1995) 2185-2198
25. Carpo R.O., and Morris A.H. Standarized single breath normal values for carbon monoxide diffusing capacity. Am Rev Respir Dis 123 (1981) 185-189
26. 2 and thiobarbituric acid reactive substances (TBARs) by healthy subjects. Free Radical Biol Med 30 (2001) 178-186
27. 2 production by marcophages and neutrophils with homovanillic acid and horseradish peroxidase. J Immunol Methods 63 (1983) 347-357
28. - in breath condensate. Clin Chim Acta 335 (2003) 65-74
29. Jones D.P., Go Y.M., Anderson C.L., Ziegler T.R., Kinkade J.M., and Kirlin W.G. Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control. FASEB J 18 (2004) 1246-1248
30. Borutaite V., and Brown G.C. Nitric oxide induces apoptosis via hydrogen peroxide, but necrosis via energy and thiol depletion. Free Radical Biol Med 35 (2003) 1457-1468
31. Motterlini R., Foresti R., Bassi R., Calabrese V., Clark J.E., and Green C.J. Endothelial heme oxygenase-1 induction by hypoxia modulation by inducible nitric-oxide synthase and S-nitrosothiols. J Biol Chem 275 (2000) 13613-13620
32. Kikugawa K., Oikawa N., Miyazawa A., Shindo K., and Kato T. Interaction of nitric oxide with glutathione or cysteine generates reactive oxygen species causing DNA single strand breaks. Biol Pharm Bull 28 (2005) 998-1003
33. Stamler J.S. S-nitrosothiols and the bioregulatory actions of nitrogen oxides through reactions with thiol groups. Curr Top Microbiol Immunol 196 (1995) 19-36
34. Snyder A.H., McPherson M.E., Hunt J.F., Johnson M., Stamler J.S., and Gaston B. Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis. Am J Respir Crit Care Med 165 (2002) 922-926
35. Beeh K.M., Beier J., Koppenhoefer N., and Buhl R. Increased glutathione disulfide and nitrosothiols in sputum supernatant of patients with stable COPD. Chest 126 (2004) 1116-1122
36. Ganas K., Loukides S., Papatheodorou G., Panagou P., and Kalogeropoulos N. Total nitrites/nitrate in expired breath condensate of patients with asthma. Respir Med 95 (2001) 649-654
37. Tomioka H., Kuwata Y., Imanaka K., Hashimoto K., Ohnishi H., Tada K., et al. A pilot study of aerosolized N-acetylcysteine for idiopathic pulmonary fibrosis. Respirology 10 (2005) 449-455
38. Decramer M., Rutten-van Molken M., Dekhuijzen P.N., Troosters T., van Herwaarden C., Pellegrino R., et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet 365 (2005) 1552-1560